The integrin adhesome network at a glance

TLDR: A new depiction of the integrin adhesome network is generated that integrates experimentally derived IAC proteomes with the literature-curated adhesomes to bridge the knowledge gap between these two resources.

Abstract: The adhesion nexus is the site at which integrin receptors bridge intracellular cytoskeletal and extracellular matrix networks The connection between integrins and the cytoskeleton is mediated by a dynamic integrin adhesion complex (IAC), the components of which transduce chemical and mechanical signals to control a multitude of cellular functions In this Cell Science at a Glance article and the accompanying poster, we integrate the consensus adhesome, a set of 60 proteins that have been most commonly identified in isolated IAC proteomes, with the literature-curated adhesome, a theoretical network that has been assembled through scholarly analysis of proteins that localise to IACs The resulting IAC network, which comprises four broad signalling and actin-bridging axes, provides a platform for future studies of the regulation and function of the adhesion nexus in health and disease