Journal ArticleDOI
The Microbiota-Gut-Brain Axis and Its Potential Therapeutic Role in Autism Spectrum Disorder
Qing Yun Li,Jie Zhou +1 more
TLDR
Application of modulators of the microbiota-gut-brain axis, such as probiotics, helminthes and certain special diets, may be a promising strategy for the treatment of ASD.About:
This article is published in Neuroscience.The article was published on 2016-06-02. It has received 168 citations till now. The article focuses on the topics: Gut–brain axis & Autism spectrum disorder.read more
Citations
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Journal ArticleDOI
The Microbiome-Gut-Brain Axis in Health and Disease.
Timothy G. Dinan,John F. Cryan +1 more
TL;DR: Manipulating the gut microbiota with psychobiotics, prebiotics, or even antibiotics offers a novel approach to altering brain function and treating gut-brain axis disorders, such as depression and autism.
Journal ArticleDOI
The Gut Microbiome Alterations and Inflammation-Driven Pathogenesis of Alzheimer’s Disease—a Critical Review
Marta Sochocka,Katarzyna Donskow-Łysoniewska,Breno S. Diniz,Donata Kurpas,Ewa Brzozowska,Jerzy Leszek +5 more
TL;DR: The inflammatory-infectious hypothesis of AD, with the great role of the gut microbiome, starts to gently push into the shadow the amyloid cascade hypothesis that has dominated for decades.
Journal Article
The role of diet on gut microbiota composition
Stefano Bibbò,Gianluca Ianiro,Giorgio,Franco Scaldaferri,Luca Masucci,Alessandro Gasbarrini,Giovanni Cammarota +6 more
TL;DR: The direct role of the diet in the composition of gut microbiota and about the possible clinical consequences are discussed.
Journal ArticleDOI
How gut microbes talk to organs: The role of endocrine and nervous routes
TL;DR: The recent advances in gut microbiota investigation as well as the discovery of specific metabolites interacting with host cells has led to the identification of novel inter-organ communication during metabolic disturbances, suggesting that gut microbes may be viewed as “novel” future therapeutic partners.
Journal ArticleDOI
The role of probiotics in children with autism spectrum disorder: A prospective, open-label study.
Sanaa Y. Shaaban,Yasmin G. El Gendy,Nayra Sh. Mehanna,Waled M. El-Senousy,Howaida S A El-Feki,Khaled Saad,Osama M. El-Asheer +6 more
TL;DR: It was concluded that probiotics have beneficial effects on both behavioral and GI manifestations of ASD, and could be recommended for children with ASD as an adjuvant therapy.
References
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Journal ArticleDOI
Diversity of the human intestinal microbial flora.
Paul B. Eckburg,Elisabeth M. Bik,Charles N. Bernstein,Elizabeth Purdom,Les Dethlefsen,Michael Sargent,Steven R. Gill,Karen E. Nelson,David A. Relman,David A. Relman,David A. Relman +10 more
TL;DR: A majority of the bacterial sequences corresponded to uncultivated species and novel microorganisms, and significant intersubject variability and differences between stool and mucosa community composition were discovered.
Journal ArticleDOI
The gut microbiota as an environmental factor that regulates fat storage
Fredrik Bäckhed,Hao Ding,Hao Ding,Ting Wang,Lora V. Hooper,Gou Young Koh,Andras Nagy,Clay F. Semenkovich,Jeffrey I. Gordon +8 more
TL;DR: In this article, the authors found that conventionalization of adult germ-free C57BL/6 mice with a normal microbiota harvested from the distal intestine (cecum) of conventionally raised animals produces a 60% increase in body fat content and insulin resistance within 14 days despite reduced food intake.
Journal ArticleDOI
Prevalence of Autism Spectrum Disorder Among Children Aged 8 Years — Autism and Developmental Disabilities Monitoring Network, 11 Sites, United States, 2014
Jon Baio,Lisa D. Wiggins,Deborah Christensen,Matthew J. Maenner,Julie L. Daniels,Zachary Warren,Margaret Kurzius-Spencer,Walter Zahorodny,Cordelia Robinson Rosenberg,Tiffany White,Maureen S. Durkin,Pamela Imm,Loizos Nikolaou,Loizos Nikolaou,Marshalyn Yeargin-Allsopp,Li-Ching Lee,Rebecca A. Harrington,Maya Lopez,Robert T. Fitzgerald,P Amy Hewitt,Sydney Pettygrove,John N. Constantino,Alison Vehorn,Josephine Shenouda,Jennifer Hall-Lande,Kim Van Naarden Braun,Nicole F. Dowling +26 more
TL;DR: This report provides updated ASD prevalence estimates for children aged 8 years during the 2014 surveillance year, on the basis of DSM-IV-TR criteria, and describes characteristics of the population of children with ASD.
Journal ArticleDOI
Host-Gut Microbiota Metabolic Interactions
Jeremy K. Nicholson,Elaine Holmes,James Kinross,Rémy Burcelin,Glenn R. Gibson,Wei Jia,Sven Pettersson +6 more
TL;DR: A deeper understanding of the axes that physiologically connect the gut, liver, muscle, and brain are a prerequisite for optimizing therapeutic strategies to manipulate the gut microbiota to combat disease and improve health.
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Microbiota Transfer Therapy alters gut ecosystem and improves gastrointestinal and autism symptoms: an open-label study
Dae Wook Kang,James B. Adams,Ann C. Gregory,Ann C. Gregory,Thomas J. Borody,Lauren Chittick,Lauren Chittick,Alessio Fasano,Alexander Khoruts,Elizabeth Geis,Juan Maldonado,Sharon McDonough-Means,Elena L. Pollard,Simon Roux,Simon Roux,Michael J. Sadowsky,Karen Schwarzberg Lipson,Matthew B. Sullivan,J. Gregory Caporaso,Rosa Krajmalnik-Brown +19 more