The murine appendiceal microbiome is altered in spontaneous colitis and its pathological progression.
TLDR
The appendiceal dysbiosis observed in Winnie mice is commensurate with, and adds to extant literature data, reports of increased Helicobacter in IBD patients.Abstract:
Background
Inflammatory bowel disease (comprising ulcerative colitis and Crohn’s disease) is a multifactorial disease that is extensively associated with stool microbiome changes (dysbiosis). Appendicitis and appendectomy limits subsequent colitis, clinically, and in animal models. We wanted to examine how the appendiceal and stool microbiome fared in our spontaneous colitic Winnie (Muc2−/−) mice model.read more
Citations
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Rhythmicity of the intestinal microbiota is regulated by gender and the host circadian clock
TL;DR: It is reported that both the host circadian system and host gender influence the rhythmicity of the total load and taxonomic abundances in the fecal microbiota, and that regulation by the host clock is dominant.
Journal ArticleDOI
Microbial network disturbances in relapsing refractory Crohn's disease.
Bahtiyar Yilmaz,Pascal Juillerat,Ove Øyås,Charlotte Ramon,Francisco Bravo,Yannick Franc,Nicolas Fournier,Pierre Michetti,Christoph Mueller,Markus B. Geuking,Valérie Pittet,Michel H. Maillard,Gerhard Rogler,Reiner Wiest,Jörg Stelling,Andrew J. Macpherson +15 more
TL;DR: A disturbed microbial network characterizes relapsing refractory Crohn’s disease and antedates disease recurrence after surgical removal of the active disease segment.
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Host immunoglobulin G selectively identifies pathobionts in pediatric inflammatory bowel diseases
H Armstrong,Misagh Alipour,Rosica Valcheva,Michael Bording-Jorgensen,Juan Jovel,Deenaz Zaidi,Prachi E. Shah,Yuefei Lou,Cory Ebeling,Andrew Mason,Dawson Lafleur,J Jerasi,Gane Ka-Shu Wong,Karen Madsen,Matthew W Carroll,Hien Q. Huynh,Levinus A. Dieleman,Eytan Wine +17 more
TL;DR: Using IgG as a marker of pathobionts in larger patient cohorts to identify microbes and elucidate their role in IBD pathogenesis will potentially underpin new strategies to facilitate development of novel, targeted diagnostic, and therapeutic approaches.
Journal ArticleDOI
Of men in mice: the development and application of a humanized gnotobiotic mouse model for microbiome therapeutics.
John Chulhoon Park,Sin-Hyeog Im +1 more
TL;DR: The key factors that affect the formulation of a humanized mouse model representative of the human gut flora are reviewed and several approaches are proposed as to how researchers can effectively design such models for clinical relevance.
Journal ArticleDOI
Polysaccharides from Chrysanthemum morifolium Ramat ameliorate colitis rats by modulating the intestinal microbiota community.
TL;DR: Chrysanthemum polysaccharides could ameliorate ulcerative colitis by fostering beneficial intestinal flora growth, modulating the balance of intestinal microecology and restoring the immune system.
References
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