The Neuropeptide Oxytocin Facilitates Pro-Social Behavior and Prevents Social Avoidance in Rats and Mice
Michael Lukas,Iulia Toth,Stefan O. Reber,David A. Slattery,Alexa H. Veenema,Alexa H. Veenema,Inga D. Neumann +6 more
TLDR
The data indicate that the basal activity of the endogenous brain OT system is sufficient to promote natural occurring social preference in rodents while synthetic OT shows potential to reverse stress-induced social avoidance and might thus be of use for treating social phobia and social dysfunction in humans.About:
This article is published in Neuropsychopharmacology.The article was published on 2011-10-01 and is currently open access. It has received 347 citations till now. The article focuses on the topics: Social relation & Social defeat.read more
Citations
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The impact of varying food availability on health and welfare in mice: Testing the Match-Mismatch hypothesis.
TL;DR: Testing the predictions of this Match-Mismatch hypothesis in laboratory mice found no indication of a mismatch effect, but various effects of low vs high food availability were found regarding the individuals' physiology and, to a small extent, their behavior.
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Transient and persistent behavioral and molecular changes in primiparous female Wistar rats
Roshan R. Naik,Trynke R. de Jong +1 more
TL;DR: The results emphasize the transient nature of these behavioral and molecular adaptations, except for a persistent up‐regulation of maternal responsiveness.
On oxytocin and social behavior
TL;DR: This thesis confirms the importance of endogenous oxytocin for social cognition in humans, and demonstrates one mechanism by which exogenous oxytoc in acts to increase the salience of human faces, which may underlie its behavioral effects.
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Does Oxytocin Impact the Psychotherapeutic Process? An Explorative Investigation of Internet-Based Cognitive-Behavioral Treatment for Posttraumatic Stress Disorder
Sinha Engel,Sarah Schumacher,Helen Niemeyer,Annika Küster,Sebastian Burchert,Heinrich Rau,Gerd-Dieter Willmund,Christine Knaevelsrud +7 more
TL;DR: Positive effects of higher pretreatment oxytocin concentrations in PTSD patients are found, indicating possible benefits of oxytoc in on trauma-focused psychotherapy.
Central Neuropeptides Social Recognition, Social Preference and Social Fear in Rodents
Michael Lukas,Iulia Toth +1 more
TL;DR: To provide evidence for neuropeptide-dependent social abilities, various behavioral assays like the social recognition/social discrimination, the social preference and the social fear conditioning paradigms are established and further developed.
References
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Oxytocin increases trust in humans
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Essential Role of BDNF in the Mesolimbic Dopamine Pathway in Social Defeat Stress
Olivier Berton,Colleen A. McClung,Ralph J. DiLeone,Vaishnav Krishnan,William Renthal,Scott J. Russo,Danielle Graham,Nadia M. Tsankova,Carlos A. Bolaños,Maribel Rios,Lisa M. Monteggia,David W. Self,Eric J. Nestler,Eric J. Nestler +13 more
TL;DR: It is shown that viral-mediated, mesolimbic dopamine pathway–specific knockdown of brain-derived neurotrophic factor is required for the development of experience-dependent social aversion in mice experiencing repeated aggression.
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Oxytocin Modulates Neural Circuitry for Social Cognition and Fear in Humans
Peter Kirsch,Christine Esslinger,Qiang Chen,Daniela Mier,Stefanie Lis,Sarina Siddhanti,Harald Gruppe,Venkata S. Mattay,Bernd Gallhofer,Andreas Meyer-Lindenberg +9 more
TL;DR: It is shown that human amygdala function is strongly modulated by oxytocin, and this results indicate a neural mechanism for the effects of Oxytocin in social cognition in the human brain and provide a methodology and rationale for exploring therapeutic strategies in disorders in which abnormal amygdala function has been implicated, such as social phobia or autism.
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Oxytocin improves "mind-reading" in humans.
TL;DR: Oxytocin improves the ability to infer the mental state of others from social cues of the eye region, and might play a role in the pathogenesis of autism spectrum disorder, which is characterized by severe social impairment.
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