The Neuropeptide Oxytocin Facilitates Pro-Social Behavior and Prevents Social Avoidance in Rats and Mice
Michael Lukas,Iulia Toth,Stefan O. Reber,David A. Slattery,Alexa H. Veenema,Alexa H. Veenema,Inga D. Neumann +6 more
TLDR
The data indicate that the basal activity of the endogenous brain OT system is sufficient to promote natural occurring social preference in rodents while synthetic OT shows potential to reverse stress-induced social avoidance and might thus be of use for treating social phobia and social dysfunction in humans.About:
This article is published in Neuropsychopharmacology.The article was published on 2011-10-01 and is currently open access. It has received 347 citations till now. The article focuses on the topics: Social relation & Social defeat.read more
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Oxytocin prevents the increase of cocaine-related responses produced by social defeat.
Carmen Ferrer-Pérez,Adriana Castro-Zavala,Miguel Luján,Joanna Filarowska,Raúl Ballestín,José Miñarro,Olga Valverde,Marta Rodríguez-Arias +7 more
TL;DR: The long‐lasting effects of RSD are counteracted by administering OXT prior to stress, and changes in BDNF expression may underlie these protective effects.
Journal ArticleDOI
Vasopressin and oxytocin in CSF and plasma of patients with aneurysmal subarachnoid haemorrhage
Jan Martin,Simone Maria Kagerbauer,Tibor Schuster,Manfred Blobner,Eberhard Kochs,Rainer Landgraf +5 more
TL;DR: Patients with poor outcome after aneurysmal SAH have lower AVP and OXT levels in CSF than patients with good outcome while neuropeptide levels in plasma failed to reflect differences in outcome.
BookDOI
New frontiers in social neuroscience
Jean Decety,Yves Christen +1 more
TL;DR: New frontiers in social neuroscience as discussed by the authors, New frontiers of social neuroscience, and new frontiers for social neuroscience are discussed in detail in Section 5.1.1].
Journal ArticleDOI
Oxytocin and MDMA (‘Ecstasy’) enhance social reward in rats
TL;DR: Results indicate that OT and MDMA can augment the rewarding effects of social interaction, but also interaction with a dynamic and tactile non-social object, which may promote social proximity by inducing generalized anxiety and defensive aggregation.
Journal ArticleDOI
Adolescent escitalopram prevents the effects of maternal separation on depression- and anxiety-like behaviours and regulates the levels of inflammatory cytokines in adult male mice
Qi Wang,Xiaomei Dong,Yan Wang,Mengxi Liu,Anji Sun,Nannan Li,Yiwei Lin,Zhongli Geng,Ye Jin,Xiaobai Li +9 more
TL;DR: The current data provide experimental evidence that MS increases depression and anxiety levels in adult male offspring and support the idea that early pharmacological intervention with ES may be an effective treatment for reducing the behavioral abnormalities induced by early adversity and regulating the underlying inflammatory mechanisms involved.
References
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Validation of open:closed arm entries in an elevated plus-maze as a measure of anxiety in the rat.
TL;DR: A novel test for the selective identification of anxiolytic and anxiogenic drug effects in the rat is described, using an elevated + -maze consisting of two open arms and two enclosed arms, which showed that behaviour on the maze was not clearly correlated either with exploratory head-dipping or spontaneous locomotor activity.
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Oxytocin increases trust in humans
TL;DR: It is shown that intranasal administration of oxytocin, a neuropeptide that plays a key role in social attachment and affiliation in non-human mammals, causes a substantial increase in trust among humans, thereby greatly increasing the benefits from social interactions.
Journal ArticleDOI
Essential Role of BDNF in the Mesolimbic Dopamine Pathway in Social Defeat Stress
Olivier Berton,Colleen A. McClung,Ralph J. DiLeone,Vaishnav Krishnan,William Renthal,Scott J. Russo,Danielle Graham,Nadia M. Tsankova,Carlos A. Bolaños,Maribel Rios,Lisa M. Monteggia,David W. Self,Eric J. Nestler,Eric J. Nestler +13 more
TL;DR: It is shown that viral-mediated, mesolimbic dopamine pathway–specific knockdown of brain-derived neurotrophic factor is required for the development of experience-dependent social aversion in mice experiencing repeated aggression.
Journal ArticleDOI
Oxytocin Modulates Neural Circuitry for Social Cognition and Fear in Humans
Peter Kirsch,Christine Esslinger,Qiang Chen,Daniela Mier,Stefanie Lis,Sarina Siddhanti,Harald Gruppe,Venkata S. Mattay,Bernd Gallhofer,Andreas Meyer-Lindenberg +9 more
TL;DR: It is shown that human amygdala function is strongly modulated by oxytocin, and this results indicate a neural mechanism for the effects of Oxytocin in social cognition in the human brain and provide a methodology and rationale for exploring therapeutic strategies in disorders in which abnormal amygdala function has been implicated, such as social phobia or autism.
Journal ArticleDOI
Oxytocin improves "mind-reading" in humans.
TL;DR: Oxytocin improves the ability to infer the mental state of others from social cues of the eye region, and might play a role in the pathogenesis of autism spectrum disorder, which is characterized by severe social impairment.
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