The Neuropeptide Oxytocin Facilitates Pro-Social Behavior and Prevents Social Avoidance in Rats and Mice
Michael Lukas,Iulia Toth,Stefan O. Reber,David A. Slattery,Alexa H. Veenema,Alexa H. Veenema,Inga D. Neumann +6 more
TLDR
The data indicate that the basal activity of the endogenous brain OT system is sufficient to promote natural occurring social preference in rodents while synthetic OT shows potential to reverse stress-induced social avoidance and might thus be of use for treating social phobia and social dysfunction in humans.About:
This article is published in Neuropsychopharmacology.The article was published on 2011-10-01 and is currently open access. It has received 347 citations till now. The article focuses on the topics: Social relation & Social defeat.read more
Citations
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Journal ArticleDOI
Balance of brain oxytocin and vasopressin: implications for anxiety, depression, and social behaviors
Inga D. Neumann,Rainer Landgraf +1 more
TL;DR: Shifting the balance between the neuropeptide systems towards oxytocin, by positive social stimuli and/or psychopharmacotherapy, may help to improve emotional behaviors and reinstate mental health.
Journal ArticleDOI
The Oxytocin Receptor: From Intracellular Signaling to Behavior
Benjamin Jurek,Inga D. Neumann +1 more
TL;DR: The mechanisms of OXT expression and release, expression and binding of the OXTR in brain and periphery, OX TR-coupled signaling cascades, and their involvement in behavioral outcomes are discussed to assemble a comprehensive picture of the central and peripheral OXT system.
Journal ArticleDOI
Animal personality and state–behaviour feedbacks: a review and guide for empiricists
Andrew Sih,Kimberley J. Mathot,Maria Moiron,Pierre-Olivier Montiglio,Max Wolf,Niels Jeroen Dingemanse +5 more
TL;DR: The role of feedbacks in recent models of adaptive personalities, and guidelines for empirical testing of model assumptions and predictions are provided, to provide a roadmap for including state-behaviour Feedbacks in behavioural ecology research.
Journal ArticleDOI
Stress and the social brain: behavioural effects and neurobiological mechanisms
Carmen Sandi,József Haller +1 more
TL;DR: Research in animals and humans has revealed some of the structural, functional and molecular changes in the brain that underlie the effects of stress on social behaviour and will have implications both for the clinic and for society.
Journal ArticleDOI
Vasopressin and oxytocin receptor systems in the brain: Sex differences and sex-specific regulation of social behavior.
Kelly M. Dumais,Alexa H. Veenema +1 more
TL;DR: This review discusses the evidence showing the presence or absence of sex differences in VP and OT receptors in rodents and humans, as well as showing new data of sexually dimorphic V1a receptor binding in the rat brain.
References
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Journal ArticleDOI
Brain oxytocin correlates with maternal aggression: link to anxiety
TL;DR: Investigation of maternal aggression and the role of brain oxytocin in lactating Wistar rats selectively bred for high anxiety-related behavior or low anxiety- related behavior during the 10 min maternal defense test found differences in intracerebral release patterns of Oxytocin are critical for the regulation of maternal aggressive behavior.
Book ChapterDOI
Involvement of the brain oxytocin system in stress coping: interactions with the hypothalamo-pituitary-adrenal axis.
TL;DR: In the present chapter, the efforts to reveal the physiological significance of intracerebrally released oxytocin in rats with respect to the regulation of the HPA axis under basal and stress conditions as well as withrespect to behavioural stress responses are summarized.
Journal ArticleDOI
An estrogen-dependent four-gene micronet regulating social recognition: A study with oxytocin and estrogen receptor-α and -β knockout mice
Elena Choleris,Jan-Ake Gustafsson,Kenneth S. Korach,Louis J. Muglia,Donald W. Pfaff,Sonoko Ogawa +5 more
TL;DR: A four-gene micronet is proposed, which links hypothalamic and limbic forebrain neurons in the estrogen control over the OT regulation of social recognition, and suggests the involvement in social recognition of the four genes coding for ER-α, ER-β, OT, and the OT receptor.
Journal ArticleDOI
Oxytocin and vasopressin release within the supraoptic and paraventricular nuclei of pregnant, parturient and lactating rats: A microdialysis study
TL;DR: The study has shown that oxytocin is released in the supraoptic and paraventricular nuclei during parturition as well as in lactation unrestrained by endogenous opioids during partuition.
Journal ArticleDOI
A randomized controlled trial of intranasal oxytocin as an adjunct to exposure therapy for social anxiety disorder.
Adam J. Guastella,Adam J. Guastella,Alexandra Howard,Mark R. Dadds,Philip B. Mitchell,Philip B. Mitchell,Dean S. Carson +6 more
TL;DR: This study shows that the administration of oxytocin improves mental representations of self, following exposure therapy, and this effects may be either short term or situation specific.
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The Oxytocin Receptor System: Structure, Function, and Regulation
Gerald Gimpl,Falk Fahrenholz +1 more