The Neuropeptide Oxytocin Facilitates Pro-Social Behavior and Prevents Social Avoidance in Rats and Mice
Michael Lukas,Iulia Toth,Stefan O. Reber,David A. Slattery,Alexa H. Veenema,Alexa H. Veenema,Inga D. Neumann +6 more
TLDR
The data indicate that the basal activity of the endogenous brain OT system is sufficient to promote natural occurring social preference in rodents while synthetic OT shows potential to reverse stress-induced social avoidance and might thus be of use for treating social phobia and social dysfunction in humans.About:
This article is published in Neuropsychopharmacology.The article was published on 2011-10-01 and is currently open access. It has received 347 citations till now. The article focuses on the topics: Social relation & Social defeat.read more
Citations
More filters
Journal ArticleDOI
Central distribution of oxytocin and vasopressin 1a receptors in juvenile Richardson's ground squirrels
TL;DR: Oxytocin and vasopressin receptors are localized in juvenile Richardson's ground squirrel brains to determine whether distribution patterns of Oxtr and Avpr1a that are associated with promiscuous mating systems differ in rodents that also exhibit non‐reproductive affiliation.
Towards a circuit-based understanding of neuropsychiatric disorders: circuit-specific contributions to major depressive disorder and addiction
TL;DR: This dissertation aims to shed light on how discrete aspects of circuits involving the NAc and VP contribute to discrete behavioral aspects of addiction and MDD, and highlights the circuit-specific changes governing neuropsychiatric disorders that may provide a platform for more specific treatments.
Journal ArticleDOI
Regulation of oxytocin receptor gene expression in obsessive–compulsive disorder: a possible role for the microbiota-host epigenetic axis
Claudio D'Addario,Mariangela Pucci,Fabio Bellia,Antonio Girella,Annalaura Sabatucci,Federico Banti,Matteo Vismara,Beatrice Benatti,Luca Ferrara,Federica Fasciana,Laura Celebre,Caterina Viganò,Luca Elli,Manuel Sergi,Mauro Maccarrone,Valeria Buzzelli,Viviana Trezza,Bernardo Dell'Osso +17 more
TL;DR: In this article , the transcriptional regulation of the oxytocin receptor gene and, in saliva, also the different levels of major phyla was investigated in socially isolated rats showing stereotyped behaviors reminiscent of OCD.
DissertationDOI
Targeting the oxytocin system to treat opioid dependence - mental health comorbidity.
TL;DR: Results show that inpatient psychosocial support was a protective factor against relapse, compared to a community centre treatment program, and the evidence for anti-addiction and pro-social properties of oxytocin, future studies would direct attention to Oxytocin-based treatment programs, looking to engage addicts in Psychosocial treatment programmes.
Journal ArticleDOI
Oxytocin and Self-Consciousness.
TL;DR: It is argued that the oxytocinergic system plays a role in modulating several levels of self-consciousness, a conclusion that is usually underscored in interpretations of previous studies.
References
More filters
Journal ArticleDOI
Validation of open:closed arm entries in an elevated plus-maze as a measure of anxiety in the rat.
TL;DR: A novel test for the selective identification of anxiolytic and anxiogenic drug effects in the rat is described, using an elevated + -maze consisting of two open arms and two enclosed arms, which showed that behaviour on the maze was not clearly correlated either with exploratory head-dipping or spontaneous locomotor activity.
Journal ArticleDOI
Oxytocin increases trust in humans
TL;DR: It is shown that intranasal administration of oxytocin, a neuropeptide that plays a key role in social attachment and affiliation in non-human mammals, causes a substantial increase in trust among humans, thereby greatly increasing the benefits from social interactions.
Journal ArticleDOI
Essential Role of BDNF in the Mesolimbic Dopamine Pathway in Social Defeat Stress
Olivier Berton,Colleen A. McClung,Ralph J. DiLeone,Vaishnav Krishnan,William Renthal,Scott J. Russo,Danielle Graham,Nadia M. Tsankova,Carlos A. Bolaños,Maribel Rios,Lisa M. Monteggia,David W. Self,Eric J. Nestler,Eric J. Nestler +13 more
TL;DR: It is shown that viral-mediated, mesolimbic dopamine pathway–specific knockdown of brain-derived neurotrophic factor is required for the development of experience-dependent social aversion in mice experiencing repeated aggression.
Journal ArticleDOI
Oxytocin Modulates Neural Circuitry for Social Cognition and Fear in Humans
Peter Kirsch,Christine Esslinger,Qiang Chen,Daniela Mier,Stefanie Lis,Sarina Siddhanti,Harald Gruppe,Venkata S. Mattay,Bernd Gallhofer,Andreas Meyer-Lindenberg +9 more
TL;DR: It is shown that human amygdala function is strongly modulated by oxytocin, and this results indicate a neural mechanism for the effects of Oxytocin in social cognition in the human brain and provide a methodology and rationale for exploring therapeutic strategies in disorders in which abnormal amygdala function has been implicated, such as social phobia or autism.
Journal ArticleDOI
Oxytocin improves "mind-reading" in humans.
TL;DR: Oxytocin improves the ability to infer the mental state of others from social cues of the eye region, and might play a role in the pathogenesis of autism spectrum disorder, which is characterized by severe social impairment.
Related Papers (5)
The Oxytocin Receptor System: Structure, Function, and Regulation
Gerald Gimpl,Falk Fahrenholz +1 more