The Neuropeptide Oxytocin Facilitates Pro-Social Behavior and Prevents Social Avoidance in Rats and Mice
Michael Lukas,Iulia Toth,Stefan O. Reber,David A. Slattery,Alexa H. Veenema,Alexa H. Veenema,Inga D. Neumann +6 more
TLDR
The data indicate that the basal activity of the endogenous brain OT system is sufficient to promote natural occurring social preference in rodents while synthetic OT shows potential to reverse stress-induced social avoidance and might thus be of use for treating social phobia and social dysfunction in humans.About:
This article is published in Neuropsychopharmacology.The article was published on 2011-10-01 and is currently open access. It has received 347 citations till now. The article focuses on the topics: Social relation & Social defeat.read more
Citations
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Journal ArticleDOI
Electro-acupuncture improves the social interaction behavior of rats.
Hong-Feng Zhang,Han-Xia Li,Yu-Chuan Dai,Xin-Jie Xu,Song-Ping Han,Rong Zhang,Rong Zhang,Ji-Sheng Han,Ji-Sheng Han +8 more
TL;DR: Activation of OXT/AVP systems may be associated with the pro-social effect caused by EA stimulation in rats subjected to a single session of EA or repeated sessions of EA.
Journal ArticleDOI
Neurobiology of the lateral septum: regulation of social behavior.
Rohit Menon,Theresa Süß,Vinícius Elias de Moura Oliveira,Vinícius Elias de Moura Oliveira,Inga D. Neumann,Anna Bludau +5 more
TL;DR: The lateral septum (LS) as mentioned in this paper is a structure of the basal forebrain that integrates abundant cortical and subcortical inputs, and projects to multiple downstream regions to generate appropriate behavioral responses.
Journal ArticleDOI
The Role of the N-Methyl-D-Aspartate Receptors in Social Behavior in Rodents.
Iulia Zoicas,Johannes Kornhuber +1 more
TL;DR: Pharmacological stimulation of the glycine-binding site either by direct stimulation or by elevating the synaptic glycine levels represents a promising strategy for the normalization of genetically-induced, pharmacologically-induced or innate deficits in social behavior.
Book ChapterDOI
Oxytocin and Olfaction.
TL;DR: Together, these recent insights highlight that Oxytocin's function in social behaviors cannot be understood without considering its actions on sensory processing.
Journal ArticleDOI
Stress, sex, and motivated behaviors.
TL;DR: Sex differences in the effects of social defeat stress on social behavior and drug‐seeking behavior as well as its impact on the mesolimbic dopamine system and the highly connected region of the bed nucleus of the stria terminalis are discussed.
References
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Validation of open:closed arm entries in an elevated plus-maze as a measure of anxiety in the rat.
TL;DR: A novel test for the selective identification of anxiolytic and anxiogenic drug effects in the rat is described, using an elevated + -maze consisting of two open arms and two enclosed arms, which showed that behaviour on the maze was not clearly correlated either with exploratory head-dipping or spontaneous locomotor activity.
Journal ArticleDOI
Oxytocin increases trust in humans
TL;DR: It is shown that intranasal administration of oxytocin, a neuropeptide that plays a key role in social attachment and affiliation in non-human mammals, causes a substantial increase in trust among humans, thereby greatly increasing the benefits from social interactions.
Journal ArticleDOI
Essential Role of BDNF in the Mesolimbic Dopamine Pathway in Social Defeat Stress
Olivier Berton,Colleen A. McClung,Ralph J. DiLeone,Vaishnav Krishnan,William Renthal,Scott J. Russo,Danielle Graham,Nadia M. Tsankova,Carlos A. Bolaños,Maribel Rios,Lisa M. Monteggia,David W. Self,Eric J. Nestler,Eric J. Nestler +13 more
TL;DR: It is shown that viral-mediated, mesolimbic dopamine pathway–specific knockdown of brain-derived neurotrophic factor is required for the development of experience-dependent social aversion in mice experiencing repeated aggression.
Journal ArticleDOI
Oxytocin Modulates Neural Circuitry for Social Cognition and Fear in Humans
Peter Kirsch,Christine Esslinger,Qiang Chen,Daniela Mier,Stefanie Lis,Sarina Siddhanti,Harald Gruppe,Venkata S. Mattay,Bernd Gallhofer,Andreas Meyer-Lindenberg +9 more
TL;DR: It is shown that human amygdala function is strongly modulated by oxytocin, and this results indicate a neural mechanism for the effects of Oxytocin in social cognition in the human brain and provide a methodology and rationale for exploring therapeutic strategies in disorders in which abnormal amygdala function has been implicated, such as social phobia or autism.
Journal ArticleDOI
Oxytocin improves "mind-reading" in humans.
TL;DR: Oxytocin improves the ability to infer the mental state of others from social cues of the eye region, and might play a role in the pathogenesis of autism spectrum disorder, which is characterized by severe social impairment.
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