The penicillin-binding proteins: structure and role in peptidoglycan biosynthesis
TLDR
An overview of the content in PBPs of some bacteria is provided with an emphasis on comparing the biochemical properties of homologous PBPs (orthologues) belonging to different bacteria.Abstract:
Penicillin-binding proteins (PBPs) have been scrutinized for over 40 years. Recent structural information on PBPs together with the ongoing long-term biochemical experimental investigations, and results from more recent techniques such as protein localization by green fluorescent protein-fusion immunofluorescence or double-hybrid assay, have brought our understanding of the last stages of the peptidoglycan biosynthesis to an outstanding level that allows a broad outlook on the properties of these enzymes. Details are emerging regarding the interaction between the peptidoglycan-synthesizing PBPs and the peptidoglycan, their mesh net-like product that surrounds and protects bacteria. This review focuses on the detailed structure of PBPs and their implication in peptidoglycan synthesis, maturation and recycling. An overview of the content in PBPs of some bacteria is provided with an emphasis on comparing the biochemical properties of homologous PBPs (orthologues) belonging to different bacteria.read more
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Uncovering the activities, biological roles, and regulation of bacterial cell wall hydrolases and tailoring enzymes.
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How Listeria monocytogenes organizes its surface for virulence.
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The cell cycle regulator GpsB functions as cytosolic adaptor for multiple cell wall enzymes.
Robert M. Cleverley,Zoe J. Rutter,Jeanine Rismondo,Federico Corona,Ho-Ching Tiffany Tsui,Fuad A. Alatawi,Richard A. Daniel,Sven Halbedel,Orietta Massidda,Orietta Massidda,Malcolm E. Winkler,Richard J. Lewis +11 more
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The Listeria monocytogenes PASTA Kinase PrkA and Its Substrate YvcK Are Required for Cell Wall Homeostasis, Metabolism, and Virulence.
Daniel A. Pensinger,Kyle Boldon,Grischa Y. Chen,William J.B. Vincent,Kyle Sherman,Meng Xiong,Adam J. Schaenzer,Emily R. Forster,Jörn Coers,Rob Striker,John-Demian Sauer +10 more
TL;DR: Two novel virulence factors essential for cytosolic survival and virulence of L. monocytogenes are identified and the importance of studying protein phosphorylation in the context of infection is illustrated.
References
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Peptidoglycan types of bacterial cell walls and their taxonomic implications.
Book
Handbook of proteolytic enzymes
TL;DR: In this paper, Serine Peptidases with a Ser/Lys Catalytic Dyad (SC) are described, as well as their relation to the Nodavirus Coat Protein.
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Peptidoglycan structure and architecture
TL;DR: In several species examined, the fine structure of the peptidoglycan significantly varies with the growth conditions, and the different models for the architecture are discussed with respect to structural and physical parameters.
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Growth of the Stress-Bearing and Shape-Maintaining Murein Sacculus of Escherichia coli
TL;DR: A model is presented that postulates that maintenance of bacterial shape is achieved by the enzyme complex copying the preexisting murein sacculus that plays the role of a template.