The Phosphatase Cdc14 Triggers Mitotic Exit by Reversal of Cdk-Dependent Phosphorylation
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This work shows that the Cdc14 phosphatase triggers mitotic exit by three parallel mechanisms, each of which inhibits Cdk activity, and induces degradation of mitotic cyclins.About:
This article is published in Molecular Cell.The article was published on 1998-12-01 and is currently open access. It has received 780 citations till now. The article focuses on the topics: Mitotic exit & Polo-like kinase.read more
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Spatial control of mitotic exit and spindle positioning in budding yeast
TL;DR: A constitutively active GTP-bound Tem1 variant is SPOCdeficient and is synthetically lethal for mutants affecting spindle positioning, and an unanticipated role of Bub2/Bfa1 and Tem1 asymmetry on Kar9 distribution and spindle Position Checkpoint is discussed.
Keywords: oocyte, meiosis, phosphatase, cell cycle, CDC14, CDH1 Topic Category: Gamete Biology
TL;DR: It is reported that CDC14B localizes with the meiotic spindle in mouse oocytes and, unlike somatic cells, it does not localize in the nucleolus, and it is revealed that experimentally alteringCDC14B levels generates eggs with abnormal spindles and chromosome alignment perturbations.
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Matrin3 regulates cell proliferation and spindle dynamics by regulating CDC14B alternative splicing
Bruna Rodrigues Muys,Roshan L. Shrestha,Dimitrios G. Anastasakis,Lőrinc S. Pongor,Xiao Ling Li,Ioannis Grammatikakis,Ahsan Habib Polash,Curtis C. Harris,Mirit I. Aladjem,Munira A. Basrai,Markus Hafner,Ashish Lal +11 more
TL;DR: This work discovered Matrin3-mediated regulation of mitotic spindle dynamics in colorectal cancer (CRC) cells and identified bound and regulated Matrin 3-target RNAs transcriptome-wide in CRC cells and found that Matrin2 broadly modulates mRNA splicing patterns.
Mitotic Exit: The Cdc14 Double Cross Dispatch
TL;DR: Two exciting new studies have confirmed the Cdc5-dependent, early anaphase release of Cdc14, and taken the story into intriguing new territory, by analysing CDC14 localisation in living cells, and independently shown that the pool of C dc14 released in early anAPHase localises to the SPBs.
References
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Cyclin-dependent kinases: engines, clocks, and microprocessors.
TL;DR: This work has shown that Cdk activity is governed by a complex network of regulatory subunits and phosphorylation events whose precise effects on Cdk conformation have been revealed by recent crystallographic studies.
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SKP1 connects cell cycle regulators to the ubiquitin proteolysis machinery through a novel motif, the F-box.
TL;DR: Different skp1 mutants arrest cells in either G1 or G2, suggesting a connection between regulation of proteolysis in different stages of the cycle.
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How proteolysis drives the cell cycle
TL;DR: Proteolysis drives cell cycle progression not only by regulating CDK activity, but by directly influencing chromosome and spindle dynamics, and also how proteolysis may directly trigger the transition from metaphase to anaphase.
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F-Box Proteins Are Receptors that Recruit Phosphorylated Substrates to the SCF Ubiquitin-Ligase Complex
TL;DR: The ubiquitination pathway for the Cdk inhibitor Sic1 is reconstituted using recombinant proteins and the constituents of the SCF complex are members of protein families, likely to serve as the prototype for a large class of E3s formed by combinatorial interactions of related family members.
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The Saccharomyces cerevisiae Cell Cycle
TL;DR: The bibliography is intended more as a guide to the literature than as a historically accurate record of the development of the field; the authors apologize to the earlier workers whose contributions thus get less explicit credit than they deserve.