Journal ArticleDOI
The present and future of nanotechnology in human health care
TLDR
In this review the chief scientific and technical aspects of nanotechnology are introduced, and some of its potential clinical applications are discussed.About:
This article is published in Nanomedicine: Nanotechnology, Biology and Medicine.The article was published on 2007-03-01. It has received 798 citations till now. The article focuses on the topics: Applications of nanotechnology.read more
Citations
More filters
Journal ArticleDOI
Synthesis of metallic nanoparticles using plant extracts.
TL;DR: The methods of making nanoparticles using plant extracts are reviewed, methods of particle characterization are reviewed and potential applications of the particles in medicine are discussed.
Journal ArticleDOI
Nanoparticles: a boon to drug delivery, therapeutics, diagnostics and imaging
TL;DR: A comprehensive review on the potential of nanotechnology in medicine focuses on different nanoparticulate drug-delivery systems including polymeric NPs, ceramic Nps, magnetic NPS, polymeric micelles and dendrimers as well as their applications in therapeutics, diagnostics and imaging.
Journal ArticleDOI
NanoGenotoxicology: The DNA damaging potential of engineered nanomaterials
Neenu Singh,Bella B. Manshian,Gareth J.S. Jenkins,Sioned M. Griffiths,Paul M. Williams,Thierry G.G. Maffeis,Chris J. Wright,Shareen H. Doak +7 more
TL;DR: Many of the engineered nanomaterials assessed were found to cause genotoxic responses, such as chromosomal fragmentation, DNA strand breakages, point mutations, oxidative DNA adducts and alterations in gene expression profiles.
Journal ArticleDOI
Selective toxicity of ZnO nanoparticles toward Gram-positive bacteria and cancer cells by apoptosis through lipid peroxidation.
Mariappan Premanathan,Krishnamoorthy Karthikeyan,Krishnamoorthy Karthikeyan,Kadarkaraithangam Jeyasubramanian,Govindasamy Manivannan +4 more
TL;DR: The toxicity of zinc oxide to bacteria was related to the generation of reactive oxygen species and to the induction of apoptosis, and these effects were differentially greater in human myeloblastic leukemia cells (HL60) than normal peripheral blood mononuclear cells.
References
More filters
Journal ArticleDOI
Semiconductor Nanocrystals as Fluorescent Biological Labels
TL;DR: Semiconductor nanocrystals prepared for use as fluorescent probes in biological staining and diagnostics have a narrow, tunable, symmetric emission spectrum and are photochemically stable.
Journal ArticleDOI
Quantum Dots for Live Cells, in Vivo Imaging, and Diagnostics
Xavier Michalet,Fabien Pinaud,Laurent A. Bentolila,James M. Tsay,Sören Doose,J. Jack Li,Gobalakrishnan Sundaresan,Anna M. Wu,Sanjiv S. Gambhir,Sanjiv S. Gambhir,Shimon Weiss +10 more
TL;DR: The new generations of qdots have far-reaching potential for the study of intracellular processes at the single-molecule level, high-resolution cellular imaging, long-term in vivo observation of cell trafficking, tumor targeting, and diagnostics.
Journal ArticleDOI
Quantum Dot Bioconjugates for Ultrasensitive Nonisotopic Detection
Warren C. W. Chan,Shuming Nie +1 more
TL;DR: Highly luminescent semiconductor quantum dots (zinc sulfide-capped cadmium selenide) have been covalently coupled to biomolecules for use in ultrasensitive biological detection and these nanometer-sized conjugates are water-soluble and biocompatible.
Journal Article
A New Concept for Macromolecular Therapeutics in Cancer Chemotherapy: Mechanism of Tumoritropic Accumulation of Proteins and the Antitumor Agent Smancs
Yasuhiro Matsumura,Hiroshi Maeda +1 more
TL;DR: It is speculated that the tumoritropic accumulation of smancs and other proteins resulted because of the hypervasculature, an enhanced permeability to even macromolecules, and little recovery through either blood vessels or lymphatic vessels in tumors of tumor-bearing mice.
Journal ArticleDOI
Tumor vascular permeability and the EPR effect in macromolecular therapeutics: a review.
TL;DR: The basic characteristics of the EPR effect, particularly the factors involved, are described, as well as its modulation for improving delivery of macromolecular drugs to the tumor.