The RAB2B-GARIL5 Complex Promotes Cytosolic DNA-Induced Innate Immune Responses
Michihiro Takahama,Mitsunori Fukuda,Norihiko Ohbayashi,Tatsuya Kozaki,Tatsuya Kozaki,Takuma Misawa,Toru Okamoto,Yoshiharu Matsuura,Shizuo Akira,Tatsuya Saitoh,Tatsuya Saitoh +10 more
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TLDR
Findings indicate that the RAB2B-GARIL5 complex promotes IFN responses against DNA viruses by regulating the cGAS-STING signaling axis.About:
This article is published in Cell Reports.The article was published on 2017-09-19 and is currently open access. It has received 20 citations till now. The article focuses on the topics: Stimulator of interferon genes & Interferon.read more
Citations
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Poxviruses Evade Cytosolic Sensing through Disruption of an mTORC1-mTORC2 Regulatory Circuit
Nathan Meade,Colleen Furey,Hua Li,Rita Verma,Qingqing Chai,Madeline G. Rollins,Stephen DiGiuseppe,Mojgan H. Naghavi,Derek Walsh +8 more
TL;DR: Ancestral conservation of Raptor/Rictor across eukaryotes, along with expression of F17 across poxviruses, suggests that mTOR dysregulation forms a conserved poxvirus strategy to counter cytosolic sensing while maintaining the metabolic benefits of mTOR activity.
Journal ArticleDOI
Baculovirus as a Tool for Gene Delivery and Gene Therapy
TL;DR: The application of baculovirus as a gene expression vector and the mechanism of the host innate immune response induced by bacULovirus in mammalian cells are summarized.
Journal ArticleDOI
Signaling Through Nucleic Acid Sensors and Their Roles in Inflammatory Diseases.
TL;DR: In this paper, the mechanisms of nucleic acid sensing by pattern recognition receptors (PRRs), including Toll-like receptors, RIG-I-like receptor, and DNA sensor molecules, and their signaling pathways as well as disorders caused by uncontrolled or unnecessary activation of these PRRs.
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mTOR Dysregulation by Vaccinia Virus F17 Controls Multiple Processes with Varying Roles in Infection.
TL;DR: The findings reveal the complex multifunctionality of F17 during infection and suggest that phosphorylation may partition F17’s functions as a structural protein and mTOR regulator.
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Vaccinia Virus Activation and Antagonism of Cytosolic DNA Sensing.
TL;DR: The recent advances on understanding of how VACV induces and antagonizes innate immune activation via cytosolic DNA sensing pathways are discussed and the implications of these findings in the rational design of vaccines and oncolytics based on VacV are discussed.
References
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Journal ArticleDOI
Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses
Hiroki Kato,Osamu Takeuchi,Shintaro Sato,Mitsutoshi Yoneyama,Masahiro Yamamoto,Kosuke Matsui,Satoshi Uematsu,Andreas Jung,Taro Kawai,Ken Ishii,Osamu Yamaguchi,Kinya Otsu,Tohru Tsujimura,Chang-Sung Koh,Caetano Reis e Sousa,Yoshiharu Matsuura,Takashi Fujita,Shizuo Akira +17 more
TL;DR: It is found that RIG-I is essential for the production of interferons in response to RNA viruses including paramyxoviruses, influenza virus and Japanese encephalitis virus, whereas MDA5 is critical for picornavirus detection.
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Cyclic GMP-AMP Synthase is a Cytosolic DNA Sensor that Activates the Type-I Interferon Pathway
TL;DR: Results indicate that cGAS is a cytosolic DNA sensor that induces interferons by producing the second messenger cGAMP, which belongs to the nucleotidyltransferase family.
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Rab GTPases as coordinators of vesicle traffic.
TL;DR: Crosstalk between multiple Rab GTPases through shared effectors, or through effectors that recruit selective Rab activators, ensures the spatiotemporal regulation of vesicle traffic.
Journal ArticleDOI
Identification and Characterization of MAVS, a Mitochondrial Antiviral Signaling Protein that Activates NF-κB and IRF3
TL;DR: The identification of a novel protein termed MAVS (mitochondrial antiviral signaling), which mediates the activation of NF-kappaB and IRF 3 in response to viral infection, and implicates a new role of mitochondria in innate immunity.
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IPS-1, an adaptor triggering RIG-I- and Mda5-mediated type I interferon induction
Taro Kawai,Ken Takahashi,Ken Takahashi,Shintaro Sato,Cevayir Coban,Himanshu Kumar,Hiroki Kato,Ken Ishii,Osamu Takeuchi,Shizuo Akira +9 more
TL;DR: IPS-1 contained an N-terminal CARD-like structure that mediated interaction with the CARD of RIG-I and Mda5, which are cytoplasmic RNA helicases that sense viral infection and blocked interferon induction by virus infection.