Journal ArticleDOI
The role of lipid-protein interactions in amyloid-type protein fibril formation.
TLDR
The present review summarizes the principal factors responsible for the enhancement of fibril formation in a membrane environment, viz. structural transformation of polypeptide chain into a partially folded conformation, increase of the local concentration of a protein upon its membrane binding, and aggregation-favoring orientation of the bound protein.About:
This article is published in Chemistry and Physics of Lipids.The article was published on 2006-06-01. It has received 267 citations till now. The article focuses on the topics: Protein tertiary structure & Protein structure.read more
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Journal ArticleDOI
The amyloid beta peptide: a chemist's perspective. Role in Alzheimer's and fibrillization.
TL;DR: The γ-secretase complex and its cell surface localization, in the absence of an effect on Notch, is studied to avoid side-effects caused by EP2 receptor.
Journal ArticleDOI
Self-assembling peptide and protein amyloids: from structure to tailored function in nanotechnology
Gang Wei,Zhiqiang Su,Nicholas P. Reynolds,Paolo Arosio,Ian W. Hamley,Ehud Gazit,Raffaele Mezzenga +6 more
TL;DR: This review will discuss recent progress made in the field of functional and artificial amyloids and highlight connections between protein/peptide folding, unfolding and aggregation mechanisms, with the resulting amyloid structure and functionality.
Journal ArticleDOI
Amyloid β Protein and Alzheimer’s Disease: When Computer Simulations Complement Experimental Studies
Jessica Nasica-Labouze,Phuong H. Nguyen,Fabio Sterpone,Olivia Berthoumieu,Nicolae-Viorel Buchete,Sébastien Côté,Alfonso De Simone,Andrew J. Doig,Peter Faller,Angel E. Garcia,Alessandro Laio,Mai Suan Li,Simone Melchionna,Normand Mousseau,Yuguang Mu,Anant K. Paravastu,Samuela Pasquali,David J. Rosenman,Birgit Strodel,Bogdan Tarus,John H. Viles,Tong Zhang,Tong Zhang,Chunyu Wang,Philippe Derreumaux,Philippe Derreumaux +25 more
TL;DR: Simulations Complement Experimental Studies Jessica Nasica-Labouze, Phuong H. Nguyen, Fabio Sterpone,† Olivia Berthoumieu,‡ Nicolae-Viorel Buchete, Sebastien Cote, Alfonso De Simone, Andrew J. Doig, and Philippe Derreumaux are authors of this paper.
Journal ArticleDOI
Membranes: a meeting point for lipids, proteins and therapies
Pablo V. Escribá,José M. González-Ros,Félix M. Goñi,Paavo K.J. Kinnunen,László Vígh,Lissete Sánchez-Magraner,Asia M. Fernández,Xavier Busquets,Ibolya Horváth,Gwendolyn Barceló-Coblijn +9 more
TL;DR: The role of membrane microdomains and lipid mediators in the control of heat‐shock protein response and stress sensing and signalling and the membrane sensor theory are studied.
Journal ArticleDOI
Amyloid seeds formed by cellular uptake, concentration, and aggregation of the amyloid-beta peptide
TL;DR: It is shown that extracellular soluble Aβ at concentrations as low as 1 nM was taken up by murine cortical neurons and neuroblastoma cells but not by human embryonic kidney (HEK293) cells, and then concentrated into endosomes/lysosomes.
References
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Journal ArticleDOI
Natively unfolded proteins: a point where biology waits for physics.
TL;DR: Results of this analysis showed that intrinsically unstructured proteins do not possess uniform structural properties, as expected for members of a single thermodynamic entity, and the Protein Quartet model, with function arising from four specific conformations (ordered forms, molten globule, premolten globules, and random coils) is discussed.
Journal ArticleDOI
Stabilization of α-Synuclein Secondary Structure upon Binding to Synthetic Membranes
TL;DR: It is reported that α-synuclein binds to small unilamellarospholipid vesicles containing acidic phospholipids, but not to vesicular charges with a net neutral charge, consistent with a role in vesicle function at the presynaptic terminal.
Book ChapterDOI
Molten globule and protein folding.
TL;DR: It is predicted and confirmed experimentally that the molten globule state can exist in a living cell and plays an important role in a number of physiological processes.
Journal ArticleDOI
How lipids affect the activities of integral membrane proteins
TL;DR: The role of non-annular, or 'co-factor' lipids, tightly bound to membrane proteins, is described, as well as the effects of charged lipids on ion concentrations close to the surface of the bilayer.
Journal ArticleDOI
Protein aggregation: folding aggregates, inclusion bodies and amyloid
TL;DR: Substantial data support the hypothesis that partially folded intermediates are key precursors to aggregates, that aggregation involves specific intermolecular interactions and that most aggregates involve beta sheets.