Journal ArticleDOI
The SLC3 and SLC7 families of amino acid transporters
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TLDR
The link between specific mutations in HATs and the primary inherited aminoacidurias, cystinuria and lysinuric protein intolerance is described.About:
This article is published in Molecular Aspects of Medicine.The article was published on 2013-04-01. It has received 487 citations till now. The article focuses on the topics: Amino acid & Efflux.read more
Citations
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Metabolism via Arginase or Nitric Oxide Synthase: Two Competing Arginine Pathways in Macrophages.
TL;DR: Understanding the arginine metabolism of M1/M2 macrophage phenotypes is central to find new possibilities to manipulate immune responses in infection, autoimmune diseases, chronic inflammatory conditions, and cancer.
Journal ArticleDOI
SLC transporters as therapeutic targets: emerging opportunities
TL;DR: Current and investigational drugs that modulate SLC transporters, as well as promising drug targets, are highlighted.
Journal ArticleDOI
Amino Acid Transporters in Cancer and Their Relevance to “Glutamine Addiction”: Novel Targets for the Design of a New Class of Anticancer Drugs
TL;DR: Four amino acid transporters have been found to be expressed at high levels in cancer and show promise in development of new tumor-imaging probes and in tumor-specific delivery of appropriately designed chemotherapeutic agents.
Journal ArticleDOI
Amino acid homeostasis and signalling in mammalian cells and organisms.
Stefan Bröer,Angelika Bröer +1 more
TL;DR: The CNS appears to generate a protein-specific response upon amino acid depletion, resulting in avoidance of an inadequate diet, and reduction in protein synthesis and amino acid oxidation are the only two measures to reduce amino acid demand.
Journal ArticleDOI
Cultivation strategies to enhance productivity of Pichia pastoris: A review
Verena Looser,Béla Brühlmann,Fabian Bumbak,Chantal Stenger,Merixtell Costa,Andrea Camattari,Dimitrios Fotiadis,Karin Kovar +7 more
TL;DR: This review focuses on particular aspects of recombinant protein production related to variations in biomass growth and their implications for strain design and screening, as well as on the concept of rational comparisons between cultivation systems for the development of specific production processes in bioreactors.
References
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Journal ArticleDOI
Clustal W and Clustal X version 2.0
Mark A. Larkin,Gordon Blackshields,Nigel P. Brown,R. Chenna,Paul A. McGettigan,Hamish McWilliam,Franck Valentin,Iain M. Wallace,Andreas Wilm,Rodrigo Lopez,J.D. Thompson,Toby J. Gibson,Desmond G. Higgins +12 more
TL;DR: The Clustal W and ClUSTal X multiple sequence alignment programs have been completely rewritten in C++ to facilitate the further development of the alignment algorithms in the future and has allowed proper porting of the programs to the latest versions of Linux, Macintosh and Windows operating systems.
Journal ArticleDOI
AMPK phosphorylation of raptor mediates a metabolic checkpoint.
Dana M. Gwinn,David B. Shackelford,Daniel F. Egan,Maria M. Mihaylova,Annabelle Mery,Debbie S. Vasquez,Benjamin E. Turk,Reuben J. Shaw +7 more
TL;DR: AMPK directly phosphorylates the mTOR binding partner raptor on two well-conserved serine residues, and this phosphorylation induces 14-3-3 binding to raptor, uncovering a conserved effector of AMPK that mediates its role as a metabolic checkpoint coordinating cell growth with energy status.
Journal ArticleDOI
The HMMTOP transmembrane topology prediction server
Gábor E. Tusnády,István Simon +1 more
TL;DR: The user is allowed to submit additional information about segment localization to enhance the prediction power, which improves the prediction accuracy as well as helps the interpretation of experimental results, i.e. in epitope insertion experiments.
Journal ArticleDOI
Bidirectional Transport of Amino Acids Regulates mTOR and Autophagy
Paul Nicklin,Philip Bergman,Bailin Zhang,Ellen Triantafellow,Henry Wang,Beat Nyfeler,Haidi Yang,Marc Hild,Charles Kung,Christine D. Wilson,Vic E. Myer,Jeffrey P. MacKeigan,Jeffrey A. Porter,Y. Karen Wang,Lewis C. Cantley,Peter Finan,Leon Murphy +16 more
TL;DR: It is shown that cellular uptake of L-glutamine and its subsequent rapid efflux in the presence of essential amino acids (EAA) is the rate-limiting step that activates mTOR.
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Crystal structure of a bacterial homologue of na(+) cl(-)-dependent neurotransmitter transporters
James Gouaux,Atsuko Yamashita +1 more
TL;DR: The structure of a bacterial homologue of these transporters from Aquifex aeolicus, in complex with its substrate, leucine, and two sodium ions, is presented and reveals the architecture of this important class of transporter, illuminates the determinants of substrate binding and ion selectivity, and defines the external and internal gates.
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