The X chromosome dosage compensation program during the development of cynomolgus monkeys.
Ikuhiro Okamoto,Tomonori Nakamura,Kotaro Sasaki,Yukihiro Yabuta,Chizuru Iwatani,Hideaki Tsuchiya,Shinichiro Nakamura,Masatsugu Ema,Masatsugu Ema,Takuya Yamamoto,Mitinori Saitou +10 more
TLDR
X chromosome dosage compensation ensures balanced gene dosage between the X chromosome and autosomes and between the sexes, involving divergent mechanisms among mammals as discussed by the authors, and elucidated a distinct me...Abstract:
X chromosome dosage compensation ensures balanced gene dosage between the X chromosome and autosomes and between the sexes, involving divergent mechanisms among mammals. We elucidated a distinct me...read more
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Journal ArticleDOI
Gene regulation in time and space during X-chromosome inactivation
TL;DR: The multiple layers of genetic and epigenetic regulation that underlie initiation of XCI during development and then maintain it throughout life are discussed, in light of the most recent findings in this rapidly advancing field.
Journal ArticleDOI
Stem-cell-derived trophoblast organoids model human placental development and susceptibility to emerging pathogens.
Rowan M. Karvas,Shafqat Ali Khan,Sonam Verma,Yan Yin,Devesha H. Kulkarni,Chen Dong,Brian Chew,E. Sane,Laura A. Fischer,Deepak Kumar,Liang Ma,Adrianus C. M. Boon,Sabine Dietmann,Indira U. Mysorekar,Thorold W. Theunissen +14 more
TL;DR: In 2018, Haider et al. as mentioned in this paper reported that trophoblast stem cells isolated from naive human pluripotent stem cells (hPSCs) can efficiently self-organize into 3D stem-cell-derived troploblast organoids (SC-TOs) with a villous architecture similar to primary trophoblasts.
Journal ArticleDOI
Noncanonical imprinting sustains embryonic development and restrains placental overgrowth
Shogo Matoba,Chisayo Kozuka,Kento Miura,Kimiko Inoue,Mami Kumon,Ryoya Hayashi,Tatsuya Ohhata,Atsuo Ogura,Azusa Inoue +8 more
TL;DR: These findings provide evidence that Xist imprinting sustains embryonic development and that autosomal noncanonical imprinting restrains placental overgrowth.
Journal ArticleDOI
Ex vivo reconstitution of fetal oocyte development in humans and cynomolgus monkeys
Ken Mizuta,Yoshitaka Katou,Baku Nakakita,Aoi Kishine,Yoshiaki Nosaka,Saki Saito,Chizuru Iwatani,Hideaki Tsuchiya,Ikuo Kawamoto,Masataka Nakaya,Tomoyuki Tsukiyama,Masahiro Nagano,Yoji Kojima,Tomonori Nakamura,Yukihiro Yabuta,Akihito Horie,Masaki Mandai,Hiroshi Ohta,Mitinori Saitou +18 more
TL;DR: A comparison of single‐cell transcriptomes among humans, monkeys, and mice unravels primate‐specific and conserved programs driving fetal oocyte development, the former including a distinct transcriptomic transformation upon oogonia‐to‐oocyte transition and the latter including two active X chromosomes with little X‐chromosome upregulation.
Journal ArticleDOI
Mechanisms of Choice in X-Chromosome Inactivation
Giulia Furlan,Rafael Galupa +1 more
TL;DR: The current understanding of the process of choice during X-chromosome inactivation and its implications is reviewed, focusing on the strategies evolved by different mammalian lineages and on the known and unknown molecular mechanisms and players involved.
References
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Journal ArticleDOI
NIH Image to ImageJ: 25 years of image analysis
TL;DR: The origins, challenges and solutions of NIH Image and ImageJ software are discussed, and how their history can serve to advise and inform other software projects.
Journal ArticleDOI
Fiji: an open-source platform for biological-image analysis
Johannes Schindelin,Ignacio Arganda-Carreras,Erwin Frise,Verena Kaynig,Mark Longair,Tobias Pietzsch,Stephan Preibisch,Curtis Rueden,Stephan Saalfeld,Benjamin Schmid,Jean-Yves Tinevez,Daniel J. White,Volker Hartenstein,Kevin W. Eliceiri,Pavel Tomancak,Albert Cardona +15 more
TL;DR: Fiji is a distribution of the popular open-source software ImageJ focused on biological-image analysis that facilitates the transformation of new algorithms into ImageJ plugins that can be shared with end users through an integrated update system.
Journal ArticleDOI
Gene Action in the X -chromosome of the Mouse ( Mus musculus L.)
TL;DR: Ohno and Hauschka1 showed that in female mice one chromosome of mammary carcinoma cells and of normal diploid cells of the ovary, mammary gland and liver was heteropyKnotic and suggested that the so-called sex chromatin was composed of one heteropyknotic X-chromosome.
Journal ArticleDOI
The male-specific region of the human Y chromosome is a mosaic of discrete sequence classes.
Helen Skaletsky,Tomoko Kuroda-Kawaguchi,Patrick Minx,Holland S. Cordum,LaDeana W. Hillier,Laura G. Brown,Sjoerd Repping,Tatyana Pyntikova,Johar Ali,Tamberlyn Bieri,Asif T. Chinwalla,Andrew Delehaunty,Kim D. Delehaunty,Hui Du,Ginger A. Fewell,Lucinda Fulton,Robert S. Fulton,Tina Graves,Shunfang Hou,Philip Latrielle,Shawn Leonard,Elaine R. Mardis,Rachel Maupin,John Douglas Mcpherson,Tracie L. Miner,William E. Nash,Christine Nguyen,Philip Ozersky,Kymberlie H. Pepin,Susan M. Rock,Tracy Rohlfing,Kelsi Scott,Brian Schultz,Cindy Strong,Aye Mon Tin-Wollam,Shiaw-Pyng Yang,Robert H. Waterston,Richard K. Wilson,Steve Rozen,David C. Page +39 more
TL;DR: The male-specific region of the Y chromosome, the MSY, differentiates the sexes and comprises 95% of the chromosome's length, and is a mosaic of heterochromatic sequences and three classes of euchromatics sequences: X-transposed, X-degenerate and ampliconic.
Journal ArticleDOI
Requirement for Xist in X chromosome inactivation
Graeme D. Penny,Graham F. Kay,Graham F. Kay,Steven A. Sheardown,Sohaila Rastan,Sohaila Rastan,Neil Brockdorff +6 more
TL;DR: Evidence for gene targeting of Xist, the proposed candidate for the X inactivation centre, is provided, and its absolute requirement in the process of X chromosome inactivation is provided.