Journal ArticleDOI
Therapeutic potential of resveratrol: the in vivo evidence.
Joseph A. Baur,David A. Sinclair +1 more
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TLDR
A comprehensive and critical review of the in vivo data on resveratrol is provided, and its potential as a therapeutic for humans is considered.Abstract:
Resveratrol, a constituent of red wine, has long been suspected to have cardioprotective effects. Interest in this compound has been renewed in recent years, first from its identification as a chemopreventive agent for skin cancer, and subsequently from reports that it activates sirtuin deacetylases and extends the lifespans of lower organisms. Despite scepticism concerning its bioavailability, a growing body of in vivo evidence indicates that resveratrol has protective effects in rodent models of stress and disease. Here, we provide a comprehensive and critical review of the in vivo data on resveratrol, and consider its potential as a therapeutic for humans.read more
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The subchronic exposure to malathion, an organophosphate pesticide, causes lipid peroxidation, oxidative stress, and tissue damage in rats: the protective role of resveratrol.
TL;DR: It is demonstrated that malathion increases oxidative stress and decreases the antioxidant status while Res has a protective function against malathions toxicity in rats.
Journal ArticleDOI
4,4′-Dihydroxy-trans-stilbene, a resveratrol analogue, exhibited enhanced antioxidant activity and cytotoxicity
Gui-Juan Fan,Xiao-Da Liu,Yi-Ping Qian,Ya-Jing Shang,Xiu-Zhuang Li,Fang Dai,Jianguo Fang,Xiao-Ling Jin,Bo Zhou +8 more
TL;DR: 4,4'-DHS exhibits remarkably higher cytotoxicity against human promyelocytic leukemia (HL-60) cells than resveratrol and the antioxidant mechanism for 4,4-DHS was proposed.
Journal ArticleDOI
Anti-angiogenic effect of resveratrol or curcumin in Ehrlich ascites carcinoma-bearing mice.
TL;DR: Both resveratrol or curcumin proved to exert their anti-angiogenic effect by inhibition of VEGF and its receptor type-2 by inhibiting angiogenesis as demonstrated by the reduction of microvessel density by these agents.
Journal ArticleDOI
Anti-proliferative and gene expression actions of resveratrol in breast cancer cells in vitro
Yu Tang Chin,Meng Ti Hsieh,Sheng Huei Yang,Po Wei Tsai,Shwu Huey Wang,Ching Chiung Wang,Yee Shin Lee,Guei Yun Cheng,Wei Chun HuangFu,David London,Heng Yuan Tang,Earl Fu,Yun Yen,Leroy F. Liu,Hung Yun Lin,Paul J. Davis +15 more
TL;DR: The microarray findings in the context of induction of anti-proliferation with brief daily exposure of cells to resveratrol—and rapid disappearance of the compound in the perfusion system—are consistent with existence of an accessible initiation site for res veratrol actions on tumor cells, e.g., the cell surface receptor for resver atrol described on integrin αvβ3.
Journal ArticleDOI
Modulating Self‐Assembly of Amyloidogenic Proteins as a Therapeutic Approach for Neurodegenerative Diseases: Strategies and Mechanisms
Tingyu Liu,Gal Bitan +1 more
TL;DR: Three prominent strategies are focused on: stabilizing the native fold of amyloidogenic proteins, accelerating the aggregation pathways towards the fibrillar endpoint thereby reducing accumulation of toxic oligomers, and modulating the assembly process towards nontoxic oligomers/aggregates.
References
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Journal ArticleDOI
Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs
TL;DR: Experiments with guinea-pig lung suggest that some of the therapeutic effects of sodium salicylate and aspirin-like drugs are due to inhibition of the synthesis of prostaglandins.
Journal ArticleDOI
Cancer Chemopreventive Activity of Resveratrol, a Natural Product Derived from Grapes
Mei-Shiang Jang,Lining Cai,George Udeani,Karla Slowing,Cathy F. Thomas,Chris Beecher,Harry H. S. Fong,Norman R. Farnsworth,A. Douglas Kinghorn,Rajendra G. Mehta,Richard C. Moon,John M. Pezzuto +11 more
TL;DR: It is suggested that resveratrol, a common constituent of the human diet, merits investigation as a potential cancer chemopreventive agent in humans.
Journal ArticleDOI
Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan
Konrad T. Howitz,Kevin J. Bitterman,Haim Y. Cohen,Dudley W. Lamming,Siva Lavu,Jason G. Wood,Robert E. Zipkin,Phuong Chung,Anne Kisielewski,Li-Li Zhang,Brandy Scherer,David A. Sinclair +11 more
TL;DR: The potent activator resveratrol, a polyphenol found in red wine, lowers the Michaelis constant of SIRT1 for both the acetylated substrate and NAD+, and increases cell survival by stimulating Sirt1-dependent deacetylation of p53.
Journal ArticleDOI
Wine, alcohol, platelets, and the French paradox for coronary heart disease
Serge Renaud,M de Lorgeril +1 more
TL;DR: Data from Caerphilly, Wales, show that platelet aggregation, which is related to CHD, is inhibited significantly by alcohol at levels of intake associated with reduced risk of CHD.
Journal ArticleDOI
An enzyme isolated from arteries transforms prostaglandin endoperoxides to an unstable substance that inhibits platelet aggregation.
TL;DR: A balance between formation of anti- and pro-aggregatory substances by enzymes could also contribute to the maintenance of the integrity of vascular endothelium and explain the mechanism of formation of intra-arterial thrombi in certain physiopathological conditions.
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