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Therapeutic potential of resveratrol: the in vivo evidence.
Joseph A. Baur,David A. Sinclair +1 more
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A comprehensive and critical review of the in vivo data on resveratrol is provided, and its potential as a therapeutic for humans is considered.Abstract:
Resveratrol, a constituent of red wine, has long been suspected to have cardioprotective effects. Interest in this compound has been renewed in recent years, first from its identification as a chemopreventive agent for skin cancer, and subsequently from reports that it activates sirtuin deacetylases and extends the lifespans of lower organisms. Despite scepticism concerning its bioavailability, a growing body of in vivo evidence indicates that resveratrol has protective effects in rodent models of stress and disease. Here, we provide a comprehensive and critical review of the in vivo data on resveratrol, and consider its potential as a therapeutic for humans.read more
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Resveratrol ameliorates hypoxia/ischemia-induced behavioral deficits and brain injury in the neonatal rat brain
Filippos Karalis,Vassiliki Soubasi,Thomas Georgiou,Christos T. Nakas,Constantina Simeonidou,Olympia Guiba-Tziampiri,Evangelia Spandou +6 more
TL;DR: Findings indicate that long-term neuroprotective effect of resveratrol on neonatal HI-induced gray and white matter damage might be associated with the preservation of behavioral functions.
Journal ArticleDOI
Dietary resveratrol increases the expression of hepatic 7α-hydroxylase and ameliorates hypercholesterolemia in high-fat fed C57BL/6J mice
TL;DR: The beneficial effects of RSV on HFD-induced hypercholesterolemia are mediated through LXRα signaling pathways, suggesting a potential target for the prevention of dyslipidemia.
Journal ArticleDOI
Resveratrol is a potent inhibitor of vascularization and cell proliferation in experimental endometriosis
TL;DR: Resveratrol inhibited angiogenesis in peritoneal and mesenteric endometriotic lesions, as indicated by a significantly reduced microvessel density when compared with controls, and represents a promising candidate therapy for future phytochemical treatment of endometRIosis.
Journal ArticleDOI
Resveratrol inhibits the release of soluble fms-like tyrosine kinase (sFlt-1) from human placenta
Melissa J. Cudmore,Wenda Ramma,Meng Cai,Takeshi Fujisawa,Shakil Ahmad,Bahjat Al-Ani,Asif Ahmed,Asif Ahmed +7 more
TL;DR: Resveratrol can inhibit sFlt-1 release and up-regulate heme oxygenase-1; thus, may offer therapeutic potential in preeclampsia.
Journal ArticleDOI
Ambient temperature influences aging in an annual fish (Nothobranchius rachovii)
Chin-Yuan Hsu,Ya-Chi Chiu +1 more
TL;DR: It is concluded that cellular metabolism, energy utilization and gene expression are altered at lower ambient temperature, which is associated with the extension of lifespan of the annual fish.
References
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Cancer Chemopreventive Activity of Resveratrol, a Natural Product Derived from Grapes
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Journal ArticleDOI
Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan
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TL;DR: Data from Caerphilly, Wales, show that platelet aggregation, which is related to CHD, is inhibited significantly by alcohol at levels of intake associated with reduced risk of CHD.
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