Journal ArticleDOI
Therapeutic potential of resveratrol: the in vivo evidence.
Joseph A. Baur,David A. Sinclair +1 more
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A comprehensive and critical review of the in vivo data on resveratrol is provided, and its potential as a therapeutic for humans is considered.Abstract:
Resveratrol, a constituent of red wine, has long been suspected to have cardioprotective effects. Interest in this compound has been renewed in recent years, first from its identification as a chemopreventive agent for skin cancer, and subsequently from reports that it activates sirtuin deacetylases and extends the lifespans of lower organisms. Despite scepticism concerning its bioavailability, a growing body of in vivo evidence indicates that resveratrol has protective effects in rodent models of stress and disease. Here, we provide a comprehensive and critical review of the in vivo data on resveratrol, and consider its potential as a therapeutic for humans.read more
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Energetics, epigenetics, mitochondrial genetics.
Douglas C. Wallace,Weiwei Fan +1 more
TL;DR: The clinical phenotypes of bioenergetic diseases are strikingly similar to those observed in epigenetic diseases (Angelman, Rett, Fragile X Syndromes, the laminopathies, cancer, etc.), and an increasing number of epigenetics diseases are being associated with mitochondrial dysfunction.
Journal ArticleDOI
Interventions to Slow Aging in Humans: Are We Ready?
Valter D. Longo,Adam Antebi,Andrzej Bartke,Nir Barzilai,Holly M. Brown-Borg,Calogero Caruso,Tyler J. Curiel,Rafael de Cabo,Claudio Franceschi,David Gems,Donald K. Ingram,Thomas E. Johnson,Brian K. Kennedy,Cynthia Kenyon,Samuel Klein,John J. Kopchick,G Lepperdinger,Frank Madeo,Mario G. Mirisola,James R. Mitchell,Giuseppe Passarino,Karl Lenhard Rudolph,John M. Sedivy,Gerald S. Shadel,David A. Sinclair,David A. Sinclair,Stephen R. Spindler,Yousin Suh,Jan Vijg,Manlio Vinciguerra,Luigi Fontana,Luigi Fontana +31 more
TL;DR: There was consensus that there is sufficient evidence that aging interventions will delay and prevent disease onset for many chronic conditions of adult and old age and their potential to be safe and effective in extending human healthspan.
Journal ArticleDOI
The potential effects of chlorogenic acid, the main phenolic components in coffee, on health: a comprehensive review of the literature
TL;DR: The effects of CGAs on different aspects of health by reviewing the related literatures have been discussed and it is postulated that CGA is able to exert pivotal roles on glucose and lipid metabolism regulation and on the related disorders, e.g. diabetes, cardiovascular disease (CVD), obesity, cancer, and hepatic steatosis.
Journal ArticleDOI
Iron behaving badly: inappropriate iron chelation as a major contributor to the aetiology of vascular and other progressive inflammatory and degenerative diseases
TL;DR: The production of peroxide and superoxide is an inevitable consequence of aerobic metabolism, and while these particular reactive oxygen species (ROSs) can exhibit a number of biological effects, they are not of themselves excessively reactive as discussed by the authors.
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Iron Behaving Badly: Inappropriate Iron Chelation as a Major Contributor to the Aetiology of Vascular and Other Progressive Inflammatory and Degenerative Diseases
TL;DR: It is argued that the role of poorly liganded iron has been rather underappreciated in the past, and that in combination with peroxide and superoxide its activity underpins the behaviour of a great many physiological processes that degrade over time.
References
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Journal ArticleDOI
Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs
TL;DR: Experiments with guinea-pig lung suggest that some of the therapeutic effects of sodium salicylate and aspirin-like drugs are due to inhibition of the synthesis of prostaglandins.
Journal ArticleDOI
Cancer Chemopreventive Activity of Resveratrol, a Natural Product Derived from Grapes
Mei-Shiang Jang,Lining Cai,George Udeani,Karla Slowing,Cathy F. Thomas,Chris Beecher,Harry H. S. Fong,Norman R. Farnsworth,A. Douglas Kinghorn,Rajendra G. Mehta,Richard C. Moon,John M. Pezzuto +11 more
TL;DR: It is suggested that resveratrol, a common constituent of the human diet, merits investigation as a potential cancer chemopreventive agent in humans.
Journal ArticleDOI
Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan
Konrad T. Howitz,Kevin J. Bitterman,Haim Y. Cohen,Dudley W. Lamming,Siva Lavu,Jason G. Wood,Robert E. Zipkin,Phuong Chung,Anne Kisielewski,Li-Li Zhang,Brandy Scherer,David A. Sinclair +11 more
TL;DR: The potent activator resveratrol, a polyphenol found in red wine, lowers the Michaelis constant of SIRT1 for both the acetylated substrate and NAD+, and increases cell survival by stimulating Sirt1-dependent deacetylation of p53.
Journal ArticleDOI
Wine, alcohol, platelets, and the French paradox for coronary heart disease
Serge Renaud,M de Lorgeril +1 more
TL;DR: Data from Caerphilly, Wales, show that platelet aggregation, which is related to CHD, is inhibited significantly by alcohol at levels of intake associated with reduced risk of CHD.
Journal ArticleDOI
An enzyme isolated from arteries transforms prostaglandin endoperoxides to an unstable substance that inhibits platelet aggregation.
TL;DR: A balance between formation of anti- and pro-aggregatory substances by enzymes could also contribute to the maintenance of the integrity of vascular endothelium and explain the mechanism of formation of intra-arterial thrombi in certain physiopathological conditions.
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