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Therapeutic potential of resveratrol: the in vivo evidence.
Joseph A. Baur,David A. Sinclair +1 more
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A comprehensive and critical review of the in vivo data on resveratrol is provided, and its potential as a therapeutic for humans is considered.Abstract:
Resveratrol, a constituent of red wine, has long been suspected to have cardioprotective effects. Interest in this compound has been renewed in recent years, first from its identification as a chemopreventive agent for skin cancer, and subsequently from reports that it activates sirtuin deacetylases and extends the lifespans of lower organisms. Despite scepticism concerning its bioavailability, a growing body of in vivo evidence indicates that resveratrol has protective effects in rodent models of stress and disease. Here, we provide a comprehensive and critical review of the in vivo data on resveratrol, and consider its potential as a therapeutic for humans.read more
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Resveratrol decreases fructose-induced oxidative stress, mediated by NADPH oxidase via an AMPK-dependent mechanism.
Pei Wen Cheng,Wen Yu Ho,Yu Ting Su,Pei Jung Lu,Bo Zone Chen,Wen Han Cheng,Wen Hsien Lu,Gwo Ching Sun,Tung Chen Yeh,Michael Hsiao,Ching-Jiunn Tseng +10 more
TL;DR: Whether resveratrol decreases the generation of reactive oxygen species (ROS), thereby reducing BP in rats with fructose‐induced hypertension, is examined.
Journal ArticleDOI
Preparation and Optimization of Resveratrol Nanosuspensions by Antisolvent Precipitation Using Box-Behnken Design
TL;DR: Results suggest that this study provides a beneficial approach to address the poor solubility issue of the resveratrol and affords a rational strategy to widen the application range of this interesting substance.
Journal ArticleDOI
Matrix effects on the bioavailability of resveratrol in humans
Jordi Ortuño,María-Isabel Covas,Magí Farré,Mitona Pujadas,Montserrat Fitó,Olha Khymenets,Cristina Andres-Lacueva,Pere N. Roset,Jesús Joglar,Rosa M. Lamuela-Raventós,Rafael de la Torre +10 more
TL;DR: Resveratrol was better absorbed from natural grape products than from tablets, pointing out the importance of the matrix in its bioavailability.
Journal ArticleDOI
Colon-specific delivery of resveratrol: optimization of multi-particulate calcium-pectinate carrier.
Surajit Das,Ka-Yun Ng +1 more
TL;DR: Observations from the present study revealed that optimized Ca-pectinate beads hardened with PEI can efficiently encapsulate resveratrol and have potential for colon-specific delivery to the lower GI tract.
Journal ArticleDOI
The emerging role of lysine acetylation of non-nuclear proteins.
Pierre Close,Catherine Creppe,Magali Gillard,Aurélie Ladang,Jean-Paul Chapelle,Laurent Nguyen,Alain Chariot +6 more
TL;DR: Protein acetylation is emerging as a major mechanism by which key proteins are regulated in many physiological processes such as migration, metabolism and aging as well as in pathological circumstances such as cancer and neurodegenerative disorders.
References
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Journal ArticleDOI
Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs
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Journal ArticleDOI
Cancer Chemopreventive Activity of Resveratrol, a Natural Product Derived from Grapes
Mei-Shiang Jang,Lining Cai,George Udeani,Karla Slowing,Cathy F. Thomas,Chris Beecher,Harry H. S. Fong,Norman R. Farnsworth,A. Douglas Kinghorn,Rajendra G. Mehta,Richard C. Moon,John M. Pezzuto +11 more
TL;DR: It is suggested that resveratrol, a common constituent of the human diet, merits investigation as a potential cancer chemopreventive agent in humans.
Journal ArticleDOI
Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan
Konrad T. Howitz,Kevin J. Bitterman,Haim Y. Cohen,Dudley W. Lamming,Siva Lavu,Jason G. Wood,Robert E. Zipkin,Phuong Chung,Anne Kisielewski,Li-Li Zhang,Brandy Scherer,David A. Sinclair +11 more
TL;DR: The potent activator resveratrol, a polyphenol found in red wine, lowers the Michaelis constant of SIRT1 for both the acetylated substrate and NAD+, and increases cell survival by stimulating Sirt1-dependent deacetylation of p53.
Journal ArticleDOI
Wine, alcohol, platelets, and the French paradox for coronary heart disease
Serge Renaud,M de Lorgeril +1 more
TL;DR: Data from Caerphilly, Wales, show that platelet aggregation, which is related to CHD, is inhibited significantly by alcohol at levels of intake associated with reduced risk of CHD.
Journal ArticleDOI
An enzyme isolated from arteries transforms prostaglandin endoperoxides to an unstable substance that inhibits platelet aggregation.
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