Journal ArticleDOI
Therapeutic potential of resveratrol: the in vivo evidence.
Joseph A. Baur,David A. Sinclair +1 more
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TLDR
A comprehensive and critical review of the in vivo data on resveratrol is provided, and its potential as a therapeutic for humans is considered.Abstract:
Resveratrol, a constituent of red wine, has long been suspected to have cardioprotective effects. Interest in this compound has been renewed in recent years, first from its identification as a chemopreventive agent for skin cancer, and subsequently from reports that it activates sirtuin deacetylases and extends the lifespans of lower organisms. Despite scepticism concerning its bioavailability, a growing body of in vivo evidence indicates that resveratrol has protective effects in rodent models of stress and disease. Here, we provide a comprehensive and critical review of the in vivo data on resveratrol, and consider its potential as a therapeutic for humans.read more
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Journal ArticleDOI
Resveratrol improves health and survival of mice on a high-calorie diet
Joseph A. Baur,Kevin J. Pearson,Nathaniel O Price,Hamish A. Jamieson,Carles Lerin,Avash Kalra,Vinayakumar Prabhu,Joanne S. Allard,Guillermo López-Lluch,Kaitlyn N. Lewis,Paul J. Pistell,Suresh Poosala,Kevin G. Becker,Olivier Boss,Dana M. Gwinn,Mingyi Wang,Sharan Ramaswamy,Kenneth W. Fishbein,Richard G. Spencer,Edward G. Lakatta,David G. Le Couteur,Reuben J. Shaw,Plácido Navas,Pere Puigserver,Donald K. Ingram,Rafael de Cabo,David A. Sinclair +26 more
TL;DR: It is shown that resveratrol shifts the physiology of middle-aged mice on a high-calorie diet towards that of mice onA standard diet and significantly increases their survival and point to new approaches for treating obesity-related disorders and diseases of ageing.
Journal ArticleDOI
Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1alpha.
Marie Lagouge,Carmen Argmann,Zachary Gerhart-Hines,Hamid Meziane,Carles Lerin,Frédéric N. Daussin,Nadia Messadeq,Jill C. Milne,Philip D. Lambert,Peter J. Elliott,Bernard Geny,Markku Laakso,Pere Puigserver,Johan Auwerx +13 more
TL;DR: RSV's effects were associated with an induction of genes for oxidative phosphorylation and mitochondrial biogenesis and were largely explained by an RSV-mediated decrease in P GC-1alpha acetylation and an increase in PGC-1 alpha activity.
Journal ArticleDOI
The grapevine genome sequence suggests ancestral hexaploidization in major angiosperm phyla.
Olivier Jaillon,Jean-Marc Aury,Benjamin Noel,Alberto Policriti,Christian Clepet,Alberto Casagrande,Nathalie Choisne,Sébastien Aubourg,Nicola Vitulo,Claire Jubin,Alessandro Vezzi,Fabrice Legeai,Philippe Hugueney,Corinne Dasilva,David S. Horner,Erica Mica,Delphine Jublot,Julie Poulain,Clémence Bruyère,Alain Billault,Béatrice Segurens,Michel Gouyvenoux,Edgardo Ugarte,Federica Cattonaro,Véronique Anthouard,Virginie Vico,Cristian Del Fabbro,Michael Alaux,Gabriele Di Gaspero,Vincent Dumas,Nicoletta Felice,Sophie Paillard,Irena Juman,Marco Moroldo,Simone Scalabrin,Aurélie Canaguier,Isabelle Le Clainche,G Malacrida,Eléonore Durand,Graziano Pesole,Valérie Laucou,Philippe Chatelet,Didier Merdinoglu,Massimo Delledonne,Mario Pezzotti,Alain Lecharny,Claude Scarpelli,François Artiguenave,M. Enrico Pè,Giorgio Valle,Michele Morgante,Michel Caboche,Anne-Françoise Adam-Blondon,Jean Weissenbach,Francis Quetier,Patrick Wincker +55 more
TL;DR: A high-quality draft of the genome sequence of grapevine is obtained from a highly homozygous genotype, revealing the contribution of three ancestral genomes to the grapevine haploid content and explaining the chronology of previously described whole-genome duplication events in the evolution of flowering plants.
Journal ArticleDOI
Plant Polyphenols: Chemical Properties, Biological Activities, and Synthesis
TL;DR: This Review gives answers from a chemical perspective, summarizes the state of the art, and highlights the most significant advances in the field of polyphenol research.
Journal ArticleDOI
Mammalian sirtuins: biological insights and disease relevance.
TL;DR: There have been major advances in the understanding of the enzymology of sirtuins, their regulation, and their ability to broadly improve mammalian physiology and health span, and the challenges that will confront the field in the coming years are discussed.
References
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Journal ArticleDOI
A validated HPLC method for the quantitative analysis of trans-resveratrol and trans-piceid in Hungarian wines
TL;DR: A new, simple procedure for the determination of phenolic components of wines, such as resveratrol and piceid isomers, has been elaborated and validated and its detection limit is found to be 0.6 pmol.
Journal ArticleDOI
Effects of Resveratrol on Acoustic Trauma
TL;DR: Results demonstrate that the resveratrol group showed reduced threshold shifts compared with the control group after noise exposure, corresponding to the region most represented by the frequency of the traumatic noise.
Journal ArticleDOI
Synergistic inhibition of HIV-1 in activated and resting peripheral blood mononuclear cells, monocyte-derived macrophages, and selected drug-resistant isolates with nucleoside analogues combined with a natural product, resveratrol.
TL;DR: It is reported that resveratrol (RV) synergistically enhances the anti‐HIV‐1 activity of the nucleoside analogues zidovudine (AZT), zalcitabine (ddC), and didanosine ( ddl), and when compared with hydroxyurea (HU), both 100 mM HU and 10 mM RV showed similar enhancement of ddI‐antiviral suppressive activity.
Journal ArticleDOI
Trans-resveratrol modulates the catalytic activity and mRNA expression of the procarcinogen-activating human cytochrome P450 1B1.
TL;DR: The novel finding that trans-resveratrol inhibits the catalytic activity and suppresses the constitutive gene expression of CYP1B1 leads to the possibility that this nutraceutical confers protection against toxicity and carcinogenicity induced by compounds that undergo CYP 1B1-catalyzed bioactivation.
Journal ArticleDOI
Caloric Restriction Mimetics: The Next Phase
TL;DR: The next phase of calorie restriction studies includes basic investigations as well as possible clinical trials of a number of candidate CR mimetics, ranging from glycolytic inhibitors to lipid‐regulating agents to antioxidants and specific gene modulators.
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Resveratrol improves health and survival of mice on a high-calorie diet
Joseph A. Baur,Kevin J. Pearson,Nathaniel O Price,Hamish A. Jamieson,Carles Lerin,Avash Kalra,Vinayakumar Prabhu,Joanne S. Allard,Guillermo López-Lluch,Kaitlyn N. Lewis,Paul J. Pistell,Suresh Poosala,Kevin G. Becker,Olivier Boss,Dana M. Gwinn,Mingyi Wang,Sharan Ramaswamy,Kenneth W. Fishbein,Richard G. Spencer,Edward G. Lakatta,David G. Le Couteur,Reuben J. Shaw,Plácido Navas,Pere Puigserver,Donald K. Ingram,Rafael de Cabo,David A. Sinclair +26 more