Journal ArticleDOI
Time-dependent vascular actions of cannabidiol in the rat aorta.
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TLDR
Results show that cannabidiol binds to and activates PPARgamma, which partially underlies the time-dependent vascular effects of cannabdiol, however, cannABidiol-induced vasorelaxation in the rat isolated aorta appears to be largely due to calcium channel inhibition.About:
This article is published in European Journal of Pharmacology.The article was published on 2009-06-10. It has received 151 citations till now. The article focuses on the topics: Cannabidiol & Cannabinoid.read more
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International Union of Basic and Clinical Pharmacology. LXXIX. Cannabinoid Receptors and Their Ligands: Beyond CB1 and CB2
Roger G. Pertwee,Allyn C. Howlett,Mary E. Abood,Stephen P.H. Alexander,V. Di Marzo,Maurice R. Elphick,Peter J. Greasley,Harald S. Hansen,George Kunos,Ken Mackie,Raphael Mechoulam,Ruth Alexandra Ross +11 more
TL;DR: This review summarizes current data indicating the extent to which cannabinoid receptor ligands undergo orthosteric or allosteric interactions with non- CB1, non-CB2 established GPCRs, deorphanized receptors such as GPR55, ligand-gated ion channels, transient receptor potential (TRP) channels, and other ion channels or peroxisome proliferator-activated nuclear receptors.
Journal ArticleDOI
Non-psychotropic plant cannabinoids: new therapeutic opportunities from an ancient herb
TL;DR: Cannabidiol and Delta(9)-tetrahydrocannabivarin, a novel CB(1) antagonist which exerts potentially useful actions in the treatment of epilepsy and obesity are given special emphasis.
Journal ArticleDOI
Molecular Targets of Cannabidiol in Neurological Disorders
Clementino Ibeas Bih,Tong Chen,Alistair V.W. Nunn,Michael Bazelot,Michael Bazelot,Mark L. Dallas,Benjamin J. Whalley +6 more
TL;DR: CBD was found to act upon a number of targets that are linked to neurological therapeutics but that its actions were not consistent with modulation of such targets that would derive a therapeutically beneficial outcome.
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Cannabidiol: State of the art and new challenges for therapeutic applications
Simona Pisanti,Anna Maria Malfitano,Elena Ciaglia,Anna Lamberti,Roberta Ranieri,Gaia Cuomo,Mario Abate,Giorgio Faggiana,Maria Proto,Donatella Fiore,Chiara Laezza,Maurizio Bifulco +11 more
TL;DR: This review highlights the pharmacological activities of CBD, its cannabinoid receptor-dependent and -independent action, its biological effects focusing on immunomodulation, angiogenetic properties, and modulation of neuronal and cardiovascular function, and the therapeutic potential of cannabidiol.
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Multiple mechanisms involved in the large-spectrum therapeutic potential of cannabidiol in psychiatric disorders
Alline C. Campos,Fabrício A. Moreira,Felipe V. Gomes,Elaine Aparecida Del Bel,Francisco Silveira Guimarães +4 more
TL;DR: Recent in vivo studies indicating that the mechanisms responsible for CBD therapeutic potential are not unitary but rather depend on the behavioural response being measured suggest activation of TRPV1 channels may help to explain the antipsychotic effect and the bell-shaped dose-response curves commonly observed with CBD.
References
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Journal ArticleDOI
Vanilloid receptors on sensory nerves mediate the vasodilator action of anandamide
Peter M. Zygmunt,Jesper Petersson,David Andersson,Huai-hu Chuang,Morten Sørgård,Vincenzo Di Marzo,David Julius,Edward D. Högestätt +7 more
TL;DR: It is shown that the vasodilator response to anandamide in isolated arteries is capsaicin-sensitive and accompanied by release of calcitonin-gene-related peptide (CGRP), which indicates that the vanilloid receptor may be another molecular target for endogenousAnandamide, besides cannabinoid receptors, in the nervous and cardiovascular systems.
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The orphan receptor GPR55 is a novel cannabinoid receptor
Erik Ryberg,Niklas Larsson,S. Sjögren,Stephan Hjorth,Nils-Olov Hermansson,J. Leonova,Thomas Elebring,Karolina Nilsson,Tomas Drmota,Peter J. Greasley +9 more
TL;DR: The endocannabinoid system functions through two well characterized receptor systems, the CB1 and CB2 receptors, and work by a number of groups in recent years has provided evidence that the system is more complicated and additional receptor types should exist to explain ligand activity in anumber of physiological processes.
Journal Article
The orphan receptor GPR55 is a novel cannabinoid receptor. Commentary
R. G. Pertwee,Erik Ryberg,Niklas Larsson,S. Sjögren,Stephan Hjorth,Nils-Olov Hermansson,J. Leonova,Thomas Elebring,Karolina Nilsson,Tomas Drmota,Peter J. Greasley +10 more
TL;DR: In this paper, the authors demonstrate that GPR55 is a novel cannabinoid receptor and its ligand profile with respect to CB 1 and CB 2 described here will permit delineation of its physiological function(s).
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The Biology of Peroxisome Proliferator-Activated Receptors: Relationship With Lipid Metabolism and Insulin Sensitivity
TL;DR: The PPARs are major regulators of lipid and glucose metabolism, allowing adaptation to the prevailing nutritional environment, and their action on muscle insulin sensitivity may be secondary to the lowering of circulating lipids on PPAR-gamma activation.
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Cannabidiol displays unexpectedly high potency as an antagonist of CB1 and CB2 receptor agonists in vitro
TL;DR: This study aimed to investigate whether the properties of cannabidiol extend to CB1 receptors expressed in mouse brain and to human CB2 receptors that have been transfected into CHO cells.