Timing to Perfection: The Biology of Central and Peripheral Circadian Clocks
TLDR
This review will highlight the relationship between clocks and metabolism, and describe how cues such as light, food, and reward mediate entrainment of the circadian system.About:
This article is published in Neuron.The article was published on 2012-04-26 and is currently open access. It has received 682 citations till now. The article focuses on the topics: Circadian clock.read more
Citations
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Transcriptional architecture of the mammalian circadian clock
TL;DR: Genome-wide analyses of the clock transcriptional feedback loop have revealed a global circadian regulation of processes such as transcription factor occupancy, RNA polymerase II recruitment and initiation, nascent transcription, and chromatin remodelling.
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Association between light at night, melatonin secretion, sleep deprivation, and the internal clock: Health impacts and mechanisms of circadian disruption.
TL;DR: Countermeasures to the effects of ALAN, such as melatonin, bright light, or psychotropic drugs, have been proposed as a means to combat circadian clock disruption and improve adaptation to shift and night work.
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BDNF mediates adaptive brain and body responses to energetic challenges
TL;DR: Findings suggest that brain-derived neurotrophic factor serves widespread roles in regulating energy homeostasis by controlling patterns of feeding and physical activity, and by modulating glucose metabolism in peripheral tissues.
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Shift work and cancer risk: potential mechanistic roles of circadian disruption, light at night, and sleep deprivation.
Erhard Haus,Michael H. Smolensky +1 more
TL;DR: The possible multiple and interconnected cancer-promoting mechanisms as a consequence of shift work are examined, i.e., repeated disruption of the circadian system, pineal hormone melatonin suppression by exposure to light at night, sleep-deprivation-caused impairment of the immune system, plus metabolic changes favoring obesity and generation of proinflammatory reactive oxygen species.
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How Might Circadian Rhythms Control Mood? Let Me Count the Ways...
TL;DR: This review will summarize recent data that implicate the circadian system as a vital regulator of a variety of systems that are thought to play a role in the development of mood disorders.
References
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Journal ArticleDOI
Nutrient control of glucose homeostasis through a complex of PGC-1alpha and SIRT1.
Joseph T. Rodgers,Carlos Lerin,Wilhelm Haas,Steven P. Gygi,Bruce M. Spiegelman,Pere Puigserver +5 more
TL;DR: It is shown that the Sir2 homologue, SIRT1 controls the gluconeogenic/glycolytic pathways in liver in response to fasting signals through the transcriptional coactivator PGC-1α, and this findings have strong implications for the basic pathways of energy homeostasis, diabetes and lifespan.
Journal ArticleDOI
Obesity and Metabolic Syndrome in Circadian Clock Mutant Mice
Fred W. Turek,Corinne E. Joshu,Corinne E. Joshu,Akira Kohsaka,Akira Kohsaka,Emily Lin,Emily Lin,Ganka Ivanova,Ganka Ivanova,Erin L. McDearmon,Erin L. McDearmon,Aaron D. Laposky,Sue Losee-Olson,Amy Easton,Dalan R. Jensen,Robert H. Eckel,Joseph S. Takahashi,Joseph S. Takahashi,Joseph Bass,Joseph Bass +19 more
TL;DR: Estimation of transcripts encoding selected hypothalamic peptides associated with energy balance was attenuated in the Clock mutant mice, suggesting that the circadian clock gene network plays an important role in mammalian energy balance.
Journal ArticleDOI
Restricted feeding uncouples circadian oscillators in peripheral tissues from the central pacemaker in the suprachiasmatic nucleus
Francesca Damiola,Nguyet Le Minh,Nicolas Preitner,Benoît Kornmann,Fabienne Fleury-Olela,Ueli Schibler +5 more
TL;DR: It is shown that temporal feeding restriction under light-dark or dark-dark conditions can change the phase of circadian gene expression in peripheral cell types by up to 12 h while leaving thephase of cyclic gene expressionIn the SCN unaffected.
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The orphan nuclear receptor REV-ERBalpha controls circadian transcription within the positive limb of the mammalian circadian oscillator.
Nicolas Preitner,Francesca Damiola,Luis-Lopez-Molina,J. Zakany,Denis Duboule,Urs Albrecht,Ueli Schibler +6 more
TL;DR: The orphan nuclear receptor REV-ERBalpha is identified as the major regulator of cyclic Bmal1 transcription, and constitutes a molecular link through which components of the negative limb drive antiphasic expression of component of the positive limb.
Journal ArticleDOI
The mammalian circadian timing system: organization and coordination of central and peripheral clocks.
TL;DR: This work discusses knowledge acquired during the past few years on the complex structure and function of the mammalian circadian timing system and some of the SCN output pathways serve as input pathways for peripheral tissues.
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The mammalian circadian timing system: organization and coordination of central and peripheral clocks.
Obesity and Metabolic Syndrome in Circadian Clock Mutant Mice
Fred W. Turek,Corinne E. Joshu,Corinne E. Joshu,Akira Kohsaka,Akira Kohsaka,Emily Lin,Emily Lin,Ganka Ivanova,Ganka Ivanova,Erin L. McDearmon,Erin L. McDearmon,Aaron D. Laposky,Sue Losee-Olson,Amy Easton,Dalan R. Jensen,Robert H. Eckel,Joseph S. Takahashi,Joseph S. Takahashi,Joseph Bass,Joseph Bass +19 more