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Journal ArticleDOI

Transcription and RNA processing by the DNA tumour viruses.

Edward B. Ziff
- 09 Oct 1980 - 
- Vol. 287, Iss: 5782, pp 491-499
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TLDR
Messenger RNA synthesis by the DNA tumour viruses proceeds by a complex but versatile series of transcription and RNA processing steps which allow them to use their genetic information to maximum advantage.
Abstract
Messenger RNA synthesis by the DNA tumour viruses proceeds by a complex but versatile series of transcription and RNA processing steps. The major mechanistic features of this pathway are probably very similar to those used by the animal cell host itself. The viruses have, however, evolved intricate arrangements of protein coding sequences and sites for RNA initiation, polyadenylation and splicing which allow them to use their genetic information to maximum advantage.

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Citations
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Journal ArticleDOI

Slipped-strand mispairing: a major mechanism for DNA sequence evolution.

TL;DR: Evidence is presented that single-base repeats (the shortest possible motifs) are represented by longer runs in mammalian introns than would be expected on a random basis, supporting the idea that SSM may be a ubiquitous force in the evolution of the eukaryotic genome.
Journal ArticleDOI

Production of a novel neuropeptide encoded by the calcitonin gene via tissue-specific RNA processing

TL;DR: The approach described here permits the application of recombinant DNA technology to analyses of complex neurobiological systems in the absence of prior structural or biological information.
Journal ArticleDOI

Alternative RNA processing in calcitonin gene expression generates mRNAs encoding different polypeptide products

TL;DR: A model in which developmental regulation of RNA processing is used to increase the diversity of neuroendocrine gene expression is proposed.
Journal ArticleDOI

Nucleotide sequences of cloned cDNAs for two types of bovine brain substance P precursor.

TL;DR: The primary structures of two types of bovine brain substance P precursors have been determined and one precursor contains a sequence homologous to that of the amphibian peptide kassinin, which suggests that it can be liberated from the precursor and may serve as an endogenous hormone or neuromediator in mammalian organisms.
References
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Journal ArticleDOI

Sizing and mapping of early adenovirus mRNAs by gel electrophoresis of S1 endonuclease-digested hybrids

TL;DR: A simple and sensitive method for detecting, sizing and mapping RNA transcripts from viral or cloned DNAs has been developed and used to examine the cytoplasmic transcripts produced during the early phase of adenovirus 2 (Ad2) infection of HeLa cells.
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Spliced segments at the 5' terminus of adenovirus 2 late mRNA

TL;DR: Four segments of viral RNA may be joined together during the synthesis of mature hexon mRNA, a model is presented for adenovirus late mRNA synthesis that involves multiple splicing during maturation of a larger precursor nuclear RNA.
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An amazing sequence arrangement at the 5′ ends of adenovirus 2 messenger RNA

TL;DR: Findings imply a new mechanism for the biosynthesis of Ad2 mRNA in mammalian cells which is complementary to sequences within the Ad2 genome which are remote from the DNA from which the main coding sequence of each mRNA is transcribed.
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Complete nucleotide sequence of SV40 DNA

TL;DR: The determination of the total 5,224 base-pair DNA sequence of the virus SV40 has enabled us to locate precisely the known genes on the genome.
Journal ArticleDOI

Ovalbumin gene: evidence for a leader sequence in mRNA and DNA sequences at the exon-intron boundaries.

TL;DR: Selected regions of cloned EcoRI fragments of the chicken ovalbumin gene have been sequenced, and a previously unreported interruption in the DNA sequences coding for the 5' nontranslated region of the messenger has been discovered.
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