Journal ArticleDOI
Transcription factor Nrf2 activation by deltamethrin in PC12 cells: Involvement of ROS.
Huangyuan Li,Siying Wu,Nian Shi +2 more
TLDR
Examination of the effects of deltamethrin on the activation and expression of Nrf2 in PC12 rat adrenal pheochromocytoma cells as a dopaminergic cell model shows that DM increases NRF2 expression and activity and that ROS is one of the mediators of this process.About:
This article is published in Toxicology Letters.The article was published on 2007-06-15. It has received 66 citations till now. The article focuses on the topics: Transcription factor & GCSH.read more
Citations
More filters
Journal ArticleDOI
Overexpression of HO-1 Protects against TNF-α-Mediated Airway Inflammation by Down-Regulation of TNFR1-Dependent Oxidative Stress
I-Ta Lee,Shue Fen Luo,Chiang-Wen Lee,Shyi-Wu Wang,Chih-Chung Lin,Chia Chi Chang,Yuh-Lien Chen,Lee-Young Chau,Chuen-Mao Yang +8 more
TL;DR: Results suggest that HO-1 functions as a suppressor of TNF-alpha signaling, not only by inhibiting the expression of adhesion molecules and generation of interleukin-6, but also by diminishing intracellular reactive oxygen species production and nuclear factor-kappaB activation in both cultured human tracheal smooth muscle cells and the airways of mice.
Journal ArticleDOI
Lipoteichoic acid induces HO-1 expression via the TLR2/MyD88/c-Src/NADPH oxidase pathway and Nrf2 in human tracheal smooth muscle cells.
I-Ta Lee,Shyi-Wu Wang,Chiang-Wen Lee,Chia Chi Chang,Chih-Chung Lin,Shue Fen Luo,Chuen-Mao Yang +6 more
TL;DR: Results demonstrated that LTA-induced ROS generation was mediated through the TLR2/MyD88/TRAF6/c-Src/NADPH oxidase pathway, in turn initiates the activation of Nrf2, and ultimately induces HO-1 expression in HTSMCs.
Journal ArticleDOI
Nrf2 Signaling, a Mechanism for Cellular Stress Resistance in Long-Lived Mice
TL;DR: Augmented activity of Nrf2 and ARE-responsive genes may coordinate many of the stress resistance traits seen in cells from these long-lived mutant mice.
Journal ArticleDOI
Lipoteichoic acid induces HO‐1 expression via the TLR‐2/MyD88/c‐Src/NADPH oxidase pathway and Nrf2 in human tracheal smooth muscle cells
Journal ArticleDOI
Deltamethrin toxicity: A review of oxidative stress and metabolism.
Qirong Lu,Yaqi Sun,Irma Ares,Arturo Anadón,Marta Martínez,María-Rosa Martínez-Larrañaga,Zonghui Yuan,Xu Wang,Xu Wang,María-Aránzazu Martínez +9 more
TL;DR: This review systematically summarizes the deltamethrin toxicity mechanism from the perspective of oxidative stress, including deltAMethrin‐mediated oxidative damage, antioxidant status, oxidative signaling pathways and modulatory effects of antagonists, synergists and placebos on oxidative stress.
References
More filters
Journal ArticleDOI
Rapid detection of octamer binding proteins with ‘mini extracts’, prepared from a small number of cells
Journal ArticleDOI
Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain
Ken Itoh,Nobunao Wakabayashi,Yasutake Katoh,Tetsuro Ishii,Kazuhiko Igarashi,James Douglas Engel,James Douglas Engel,Masayuki Yamamoto +7 more
TL;DR: It is postulate that Keap1 and Nrf2 constitute a crucial cellular sensor for oxidative stress, and together mediate a key step in the signaling pathway that leads to transcriptional activation by this novel NRF2 nuclear shuttling mechanism.
Journal ArticleDOI
Direct evidence that sulfhydryl groups of Keap1 are the sensors regulating induction of phase 2 enzymes that protect against carcinogens and oxidants
Albena T. Dinkova-Kostova,W. David Holtzclaw,Robert N. Cole,Ken Itoh,Nobunao Wakabayashi,Yasutake Katoh,Masayuki Yamamoto,Paul Talalay +7 more
TL;DR: This finding suggests that reaction of cysteine thiols is followed by rapid formation of protein disulfide linkages, which are the direct sensors of inducers of the phase 2 system.
Journal ArticleDOI
The antioxidant responsive element. Activation by oxidative stress and identification of the DNA consensus sequence required for functional activity.
TL;DR: The data suggest that the sequence, 5'-puGTGACNNNGC-3' 3'-pyCACTGNNNCG-5' where N is any nucleotide, represents the core sequence of the ARE required for transcriptional activation by phenolic antioxidants and metabolizable planar aromatic compounds.
Journal ArticleDOI
Transcription Factor Nrf2 Coordinately Regulates a Group of Oxidative Stress-inducible Genes in Macrophages
Tetsuro Ishii,Ken Itoh,Satoru Takahashi,Hideyo Sato,Toru Yanagawa,Yasutake Katoh,Shiro Bannai,Masayuki Yamamoto +7 more
TL;DR: It is shown that Nrf2 controls the expression of a group of electrophile- and oxidative stress-inducible proteins and activities, which includes heme oxygenase-1, A170, peroxiredoxin MSP23, and cystine membrane transport (system xc −) activity.