Treatment of restless legs syndrome: an evidence-based review and implications for clinical practice.

TLDR: An evidence‐based review of the medical literature on treatment modalities used to manage patients with RLS found that levodopa, ropinirole, pramipexole, cabergoline, pergolide, and gabapentin are considered efficacious for the treatment of RLS and oral iron is considered investigational; however, its efficacy appears to depend on the iron status of subjects.

Abstract: Only in the last three decades, the restless legs syndrome (RLS) has been examined in randomized controlled trials. The Movement Disorder Society (MDS) commissioned a task force to perform an evidence-based review of the med- ical literature on treatment modalities used to manage patients with RLS. The task force performed a search of the published literature using electronic databases. The therapeu- tic efficacy of each drug was classified as being either effica- cious, likely efficacious, investigational, nonefficacious, or lacking sufficient evidence to classify. Implications for clini- cal practice were generated based on the levels of evidence and particular features of each modality, such as adverse