Triaza-based amphiphilic chelators: Synthetic route, in vitro characterization and in vivo studies of their Ga(III) and Al(III) chelates
TLDR
The synthesis and in vitro and in vivo studies of a series of micelles-forming Ga(III) chelates targeted for the liver are described, showing higher liver uptake for [(67)Ga](NOTAC8) in comparison to [(67]Ga]( NOTAC6), consistent with a longer alpha-alkyl chain and a higher lipophilicity.About:
This article is published in Journal of Inorganic Biochemistry.The article was published on 2010-10-01 and is currently open access. It has received 25 citations till now. The article focuses on the topics: Blood serum.read more
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Prospective of ⁶⁸Ga-radiopharmaceutical development.
TL;DR: The future development of the 68Ga-radiopharmaceuticals must be put in the context of several aspects such as role of PET in nuclear medicine, unmet medical needs, identification of new biomarkers, targets and corresponding ligands, production and availability of 68Ga, automation of the radiopharm pharmaceutical production, progress of positron emission tomography technologies and image analysis methodologies.
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High-Yielding Aqueous 18F-Labeling of Peptides via Al18F Chelation
Christopher A. D’Souza,William J. McBride,Robert M. Sharkey,Louis Todaro,David M. Goldenberg +4 more
TL;DR: The results demonstrate the facile application of Al(18)F chelation using BFC 1 as a versatile labeling method for radiofluorinating other heat-stable peptides for positron emission imaging.
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Complexation of metal ions with TRAP (1,4,7-triazacyclononane phosphinic acid) ligands and 1,4,7-triazacyclononane-1,4,7-triacetic acid: phosphinate-containing ligands as unique chelators for trivalent gallium.
Jakub Šimeček,Martin Schulz,Johannes Notni,Jan Plutnar,Vojtěch Kubíček,Jana Havlíčková,Petr Hermann +6 more
TL;DR: Complex formation studies in acidic solutions indicate that Ga(3+) complexes of the phosphinate ligands are formed quickly (minutes) and quantitatively even at pH <2.5, and the discussed TRAP ligANDs are suitable alternatives for the development of (68)Ga radiopharmaceuticals.
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68Ga-Labeled Gold Glyconanoparticles for Exploring Blood–Brain Barrier Permeability: Preparation, Biodistribution Studies, and Improved Brain Uptake via Neuropeptide Conjugation
TL;DR: The synthesis of novel water-soluble and biocompatible glucose-coated gold nanoparticles (GNPs) carrying BBB-permeable neuropeptides and a chelator of the positron emitter (68)Ga as a PET reporter for in vivo tracking biodistribution is developed.
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[18F]-Group 13 fluoride derivatives as radiotracers for positron emission tomography
TL;DR: The key fluoride-binding motifs covered in this review include the trifluoroborate unit bound to neutral or cationic electron deficient backbones, the BF2 unit of BODIPY dyes, and AlF or GaF3 units coordinated to multidentate Lewis basic ligands.
References
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1,4,7-Triazacyclononane-N,N',N''-triacetate (TCTA), a new hexadentate ligand for divalent and trivalent metal ions. Crystal structures of [CrIII(TCTA)], [FeIII(TCTA)], and Na[CuII(TCTA)].bul.2NaBr.bul.8H2O
Karl Wieghardt,Ursula Bossek,Phalguni Chaudhuri,Willy Herrmann,Bernhard C. Menke,Johannes Weiss +5 more
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PET Chemistry: The Driving Force in Molecular Imaging
TL;DR: Positron Emission Tomography Imaging as a Key Enabling Technology in Drug Development and Pharmacological Prerequisites for PET Ligands and Practical Issues in Preclinical PET Research are discussed.
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Metallosurfactants: interfaces and micelles.
TL;DR: This review discusses the small number of key papers that are quantifying the physico-chemical properties of metallosurfactants and highlights their " classical" as well as "non-classical" surfactant behaviour, providing an insight into the structure of micelles and films formed from these novel materials.
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A novel hexachelating amino-thiol ligand and its complex with gallium(III)
TL;DR: In this paper, the gallium is fully chelated in a slightly distorted octahedral environment by the three amine nitrogens and the three thiolate sulfurs in benzene.
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Crystallographic and Thermodynamic Study of Metal Ion Size Selectivity in the Ligand 1,4,7-Triazacyclononane- N, N',N"-triacetate
TL;DR: The inclusion of a molecular species, viz. an attached ester function, inside a macrocyclic polymetallic toroid NiJSR, as suggested first by Dahl,4 has been observed in Ni8- (SCH,COOEt), which is the first octagonal toroid.