Triaza-based amphiphilic chelators: Synthetic route, in vitro characterization and in vivo studies of their Ga(III) and Al(III) chelates
TLDR
The synthesis and in vitro and in vivo studies of a series of micelles-forming Ga(III) chelates targeted for the liver are described, showing higher liver uptake for [(67)Ga](NOTAC8) in comparison to [(67]Ga]( NOTAC6), consistent with a longer alpha-alkyl chain and a higher lipophilicity.About:
This article is published in Journal of Inorganic Biochemistry.The article was published on 2010-10-01 and is currently open access. It has received 25 citations till now. The article focuses on the topics: Blood serum.read more
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Magnetic Nanocarrier Containing 68Ga–DTPA Complex for Targeted Delivery of Doxorubicin
TL;DR: It is expected that the multi-modal nanocarrier, Fe3O4@SiO2–APTES–DTPA–Ga–DOX, can have theranostic (therapeutic and diagnostic) applications.
Journal ArticleDOI
Gallium(III) chelates of mixed phosphonate-carboxylate triazamacrocyclic ligands relevant to nuclear medicine: Structural, stability and in vivo studies
M. I. M. Prata,João P. André,Zoltan Kovacs,Anett Takács,Gyula Tircsó,Imre Tóth,Carlos F. G. C. Geraldes +6 more
TL;DR: Three triaza macrocyclic ligands, H6NOTP (1,4,7-triazacyclononane-N,N',N″-trimethylene phosphonic acid), and their gallium(III) chelates were studied in view of their potential interest as scintigraphic and PET (Positron Emission Tomography) imaging agents.
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Facile synthesis of diphenylmethyl esters from 2-diphenylmethoxypyridine using catalytic boron trifluoride·diethyl etherate
Minh Thanh La,Hee-Kwon Kim +1 more
TL;DR: In this paper, a practical method for the direct preparation of diphenylmethyl (DPM) esters from 2-diphenylmethoxypyridine is described.
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Nanomaterial Probes for Nuclear Imaging
Vanessa Jing Xin Phua,Chang-Tong Yang,Bin Xia,Sean X. Yan,Jiang Liu,Swee Eng Aw,Tao He,David Chee Eng Ng +7 more
TL;DR: New developments in nanomaterials are expected to introduce a paradigm shift in nuclear imaging, thereby creating new opportunities for theranostic medical imaging tools.
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Ga[NO2A-N-(α-amino)propionate] chelates: synthesis and evaluation as potential tracers for 68Ga PET
Miguel Ferreira,Goretti Pereira,João P. André,M. I. M. Prata,Paula M. T. Ferreira,José A. Martins,Carlos F. G. C. Geraldes +6 more
TL;DR: In this paper, the authors introduced the NO2A-N-(α-amino)propionic acid family of chelators based on the triazacyclononane scaffold.
References
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Long-Circulating and Target-Specific Nanoparticles: Theory to Practice
TL;DR: The surface mechanisms, which affords red blood cells long-circulatory lives and the ability of specific microorganisms to evade macrophage recognition, are explored and the rational approaches in the design as well as the biological performance of such constructs are assessed.
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Lipid-based nanoparticles for contrast-enhanced MRI and molecular imaging.
Willem J. M. Mulder,Gustav J. Strijkers,Geralda A. F. van Tilborg,Arjan W. Griffioen,Klaas Nicolay +4 more
TL;DR: An overview of different lipidic nanoparticles for use in MRI is given, with the main emphasis on Gd–based contrast agents.
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PEG-based micelles as carriers of contrast agents for different imaging modalities
TL;DR: Brief analysis of the micellization process and micelle properties shows that micelles made of amphiphilic co-polymers seem to be the most attractive for practical application.
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Thermodynamic binding constants for gallium transferrin.
TL;DR: Thermodynamic binding constants for gallium complexation at the two specific metal binding sites of human serum transferrin at pH 7.4 and 5 mM NaHCO3 have been determined by UV difference spectroscopy and are discussed in relation to the thermodynamics of transferrin binding of Fe3+.
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A fluorimetric method for the estimation of the critical micelle concentration of surfactants
TL;DR: The present work investigates the possibility of a rapid estimation of critical micelle concentration (cmc) of surfactants by means of soluble fluorescent probes and is independent of the cmc value within a wide range of concentrations.