Journal ArticleDOI
Tropoelastin coated PLLA-PLGA scaffolds promote vascular network formation.
Shira Landau,Ariel A. Szklanny,Giselle C. Yeo,Yulia Shandalov,Elena Kosobrodova,Anthony S. Weiss,Shulamit Levenberg +6 more
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TLDR
Implantation of tropoelastin-treated scaffolds into mouse abdominal muscle resulted in enhanced perfusion of the penetrating vasculature and improved integration, pointing to the great potential of these combined materials in promoting the vascularization of implanted engineered constructs, which can be further exploited in the fabrication of clinically relevant engineered tissues.About:
This article is published in Biomaterials.The article was published on 2017-04-01. It has received 42 citations till now. The article focuses on the topics: Tropoelastin & Tissue engineering.read more
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Journal ArticleDOI
Emerging bone tissue engineering via Polyhydroxyalkanoate (PHA)-based scaffolds.
TL;DR: The various properties PHA scaffold that make them suitable for bone tissue engineering such as biocompatibility, biodegradability, mechanical properties as well as vascularization are introduced.
Journal ArticleDOI
Tissue Engineering for Clean Meat Production
Tom Ben-Arye,Shulamit Levenberg +1 more
TL;DR: This review focuses on tissue engineering of skeletal muscle and the adjustments needed for clean meat development, and elaborate on cell types from farm animals that have the potential to recapitulate the muscle ECM, blood vessels, muscle fibers and fat deposits.
Journal ArticleDOI
Tropoelastin Implants That Accelerate Wound Repair
Suzanne M. Mithieux,Behnaz Aghaei-Ghareh-Bolagh,Le-Ping Yan,Kekini V. Kuppan,Kekini V. Kuppan,Yiwei Wang,Francia Garces-Suarez,Zhe Li,Peter K.M. Maitz,Elizabeth A. Carter,Christina Limantoro,Wojciech Chrzanowski,David Cookson,Alan Riboldi-Tunnicliffe,Clair Baldock,Kosuke Ohgo,Kristin K. Kumashiro,Glenn A. Edwards,Anthony S. Weiss +18 more
TL;DR: A novel, pure, synthetic material is presented that promotes the repair of full‐thickness skin wounds using a novel heat‐based, stabilized form of human tropoelastin which allows for tunable resorption.
Journal ArticleDOI
Mature vessel networks in engineered tissue promote graft-host anastomosis and prevent graft thrombosis.
TL;DR: The importance of establishing mature and complex vessel networks in engineered tissues before implantation to promote anastomosis with the host and accelerate graft perfusion is demonstrated.
Journal ArticleDOI
Promoting endothelial cell affinity and antithrombogenicity of polytetrafluoroethylene (ptfe) by mussel-inspired modification and rgd/heparin grafting
TL;DR: A mussel-inspired modification approach was employed to enable the grafting of various bioactive molecules like RGD and heparin to stimulate fast endothelialization and effective antithrombosis and provides a promising technique for SDVG modification.
References
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Journal ArticleDOI
Basic and Therapeutic Aspects of Angiogenesis
TL;DR: The emerging principles of vascular growth provide exciting new perspectives, the translation of which might overcome the current limitations of pro- and antiangiogenic medicine.
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Pericytes: developmental, physiological, and pathological perspectives, problems, and promises.
TL;DR: The history of investigations into pericytes, the mural cells of blood microvessels, are reviewed, emerging concepts are indicated, and problems and promise are pointed out.
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Vascularized and functional human liver from an iPSC-derived organ bud transplant
Takanori Takebe,Keisuke Sekine,Masahiro Enomura,Hiroyuki Koike,Masaki Kimura,Takunori Ogaeri,Ran-Ran Zhang,Yasuharu Ueno,Yun-Wen Zheng,Naoto Koike,Shinsuke Aoyama,Yasuhisa Adachi,Hideki Taniguchi +12 more
TL;DR: This is the first report demonstrating the generation of a functional human organ from pluripotent stem cells by transplantation of liver buds created in vitro (iPSC-LBs), and provides a promising new approach to study regenerative medicine.
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The role of pericytes in blood-vessel formation and maintenance
Gabriele Bergers,Steven Song +1 more
TL;DR: This review article describes the current knowledge about the nature of pericytes and their functions during vessel growth, vessel maintenance, and pathological angiogenesis.
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Engineering vascularized skeletal muscle tissue.
Shulamit Levenberg,Shulamit Levenberg,Jeroen Rouwkema,Mara L. Macdonald,Evan S. Garfein,Daniel S. Kohane,Diane C. Darland,Robert P. Marini,Clemens van Blitterswijk,Richard C. Mulligan,Patricia A. D'Amore,Robert Langer +11 more
TL;DR: The induction of endothelial vessel networks in engineered skeletal muscle tissue constructs using a three-dimensional multiculture system consisting of myoblasts, embryonic fibroblasts and endothelial cells coseeded on highly porous, biodegradable polymer scaffolds is described.