Tumor Promotion via Injury- and Death-Induced Inflammation
Reads0
Chats0
TLDR
A resolution to this paradox based on cell death-mediated induction of tumor promoting inflammatory cytokines, which enhance cell survival and trigger compensatory proliferation in response to tissue injury is discussed.About:
This article is published in Immunity.The article was published on 2011-10-28 and is currently open access. It has received 243 citations till now. The article focuses on the topics: Proinflammatory cytokine & Tumor promotion.read more
Citations
More filters
Journal ArticleDOI
Inflammation and Cancer: Triggers, Mechanisms, and Consequences.
TL;DR: How tumor-promoting inflammation closely resembles inflammatory processes typically found during development, immunity, maintenance of tissue homeostasis, or tissue repair is discussed and the distinctions between tissue-protective and pro-tumorigenic inflammation are illuminated.
Journal ArticleDOI
Essential metabolic, anti-inflammatory, and anti-tumorigenic functions of miR-122 in liver
Shu-Hao Hsu,Bo Wang,Janaiah Kota,Jianhua Yu,Stefan Costinean,Huban Kutay,Lianbo Yu,Shoumei Bai,Shoumei Bai,Krista M. D. La Perle,Raghu R. Chivukula,Hsiaoyin Mao,Min Wei,K. Reed Clark,K. Reed Clark,Jerry R. Mendell,Jerry R. Mendell,Michael A. Caligiuri,Samson T. Jacob,Joshua T. Mendell,Kalpana Ghoshal +20 more
TL;DR: It is demonstrated that deletion of mouse Mir122 resulted in hepatosteatosis, hepatitis, and the development of tumors resembling HCC, demonstrating critical functions for miR-122 in the maintenance of liver homeostasis and have important therapeutic implications, including the potential utility of mi R-122 delivery for selected patients with HCC and the need for careful monitoring of patients receiving miR -122 inhibition therapy for HCV.
Journal ArticleDOI
Immunity, inflammation, and cancer: an eternal fight between good and evil
Shabnam Shalapour,Michael Karin +1 more
TL;DR: This antagonism between inflammation and immunity also affects the outcome of cancer treatment and needs to be considered when designing new therapeutic approaches.
Journal ArticleDOI
Inflammation and colorectal cancer: colitis-associated neoplasia
TL;DR: Mechanisms of CAC tumorigenesis as well as new possible hints for the future approaches for prevention and therapy are discussed in this review.
Journal ArticleDOI
Inflammation and tumor progression: signaling pathways and targeted intervention.
TL;DR: In this article, the authors discuss the initiation and resolution of inflammation, the crosstalk between tumor development and inflammatory processes, and highlight potential targets for harnessing inflammation in the treatment of cancer.
References
More filters
Journal ArticleDOI
The hallmarks of cancer.
TL;DR: This work has been supported by the Department of the Army and the National Institutes of Health, and the author acknowledges the support and encouragement of the National Cancer Institute.
Journal ArticleDOI
Cancer-related inflammation.
TL;DR: The molecular pathways of this cancer-related inflammation are now being unravelled, resulting in the identification of new target molecules that could lead to improved diagnosis and treatment.
Journal ArticleDOI
Immunity, Inflammation, and Cancer
TL;DR: The principal mechanisms that govern the effects of inflammation and immunity on tumor development are outlined and attractive new targets for cancer therapy and prevention are discussed.
Journal ArticleDOI
Hepatocellular Carcinoma: Epidemiology and Molecular Carcinogenesis
TL;DR: A detailed understanding of epidemiologic factors and molecular mechanisms associated with HCC ultimately could improve current concepts for screening and treatment of this disease.
Journal ArticleDOI
An endotoxin-induced serum factor that causes necrosis of tumors
TL;DR: It is proposed that TNF mediates endotoxin-induced tumor necrosis, and that it may be responsible for the suppression of transformed cells by activated macrophages.