Journal ArticleDOI
Tumors: wounds that do not heal. Similarities between tumor stroma generation and wound healing.
Reads0
Chats0
TLDR
Tumors of epithelioma are composed of two discrete but interdependent compartments: the malignant cells themselves and the stroma that they induce and in which they are dispersed.Abstract:
SOLID tumors are composed of two discrete but interdependent compartments: the malignant cells themselves and the stroma that they induce and in which they are dispersed.1 , 2 In tumors of epitheli...read more
Citations
More filters
Journal ArticleDOI
Circulating tumor cell enrichment based on physical properties.
TL;DR: Intrinsic physical properties of CTCs, including cell size, deformability, and electrical properties, are reviewed, and technologies developed to exploit them for enrichment from blood are summarized.
Journal ArticleDOI
Matrix changes induced by transglutaminase 2 lead to inhibition of angiogenesis and tumor growth
Richard A. Jones,P. Kotsakis,Timothy S. Johnson,David Y.S. Chau,David Y.S. Chau,S. Ali,Gerry Melino,Martin Griffin +7 more
TL;DR: Administration of active TG2 to two different in vitro angiogenesis assays resulted in the accumulation of a complex extracellular matrix leading to the suppression of endothelial tube formation without causing cell death, leading to a new approach to solid tumor therapy.
Journal ArticleDOI
Tumor endothelial marker 1 (Tem1) functions in the growth and progression of abdominal tumors
Akash Nanda,Baktiar O. Karim,Zhongsheng Peng,Guosheng Liu,Weiping Qiu,Christine Gan,Bert Vogelstein,Brad St. Croix,Kenneth W. Kinzler,David L. Huso +9 more
TL;DR: Data indicate that the stroma can control tumor aggressiveness and that this control varies with anatomic site, which has significant implications for the mechanisms underlying tumor invasiveness and for models that evaluate this process.
Journal ArticleDOI
Fibroblast activation protein: A potential therapeutic target in cancer.
TL;DR: Fiberroblast activation protein, a member of the serine protease family, selectively expressed in the stromal fibroblasts associated with epithelial cancers, whereas with low or undetectable expression in the resting fibro Blasts of normal adult tissues, is a potential target for novel anticancer therapies, such as those by immune-based approaches.
References
More filters
Book
Pathologic basis of disease
TL;DR: The objective is to establish an experimental procedure and show direct AFM progression from EMT to EMT using a simple, straightforward, and reproducible procedure.
Journal ArticleDOI
Tumor cells secrete a vascular permeability factor that promotes accumulation of ascites fluid.
Donald R. Senger,Stephen J. Galli,Ann M. Dvorak,Carole A. Perruzzi,V. Susan Harvey,Harold F. Dvorak +5 more
TL;DR: Tumor ascites fluids from guinea pigs, hamsters, and mice contain activity that rapidly increases microvascular permeability, and this activity is secreted by these tumor cells and a variety of other tumor cell lines in vitro.
Book ChapterDOI
Plasminogen activators, tissue degradation, and cancer.
Keld Danø,Peter A. Andreasen,J Grøndahl-Hansen,Peter Marcus Kristensen,L.S. Nielsen,L. Skriver +5 more
TL;DR: This chapter describes two types of plasminogen activators—namely, the urokinase-type plasMinogen activator (u-PA) and the tissue- type plasmineg activator(t-PA), which are essentially different gene products.
Journal ArticleDOI
The biology of platelet-derived growth factor
TL;DR: The biology of platelet derived growth factor, it will really give you the good idea to be successful.
Journal Article
The role of the macrophage in wound repair. A study with hydrocortisone and antimacrophage serum.
Samuel Leibovich,R. Ross +1 more
TL;DR: The role of the macrophage in wound repair has been investigated by studying the healing process in wounds depleted of this cell and/or its phagocytic activity as discussed by the authors, where hydrocortisone acetate administered as a subcutaneous depot was used to induce a prolonged monocytopenia in guinea pigs, and antimacrophage serum (AMS) was used for local elimination of tissue macrophages.