Journal ArticleDOI
Tumors: wounds that do not heal. Similarities between tumor stroma generation and wound healing.
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Tumors of epithelioma are composed of two discrete but interdependent compartments: the malignant cells themselves and the stroma that they induce and in which they are dispersed.Abstract:
SOLID tumors are composed of two discrete but interdependent compartments: the malignant cells themselves and the stroma that they induce and in which they are dispersed.1 , 2 In tumors of epitheli...read more
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Journal ArticleDOI
VEGF localisation in diabetic retinopathy
TL;DR: Moderate to intense immunostaining was observed in all fibrovascular and fibrocellular membranes examined and supports a circumstantial role for VEGF in the pathogenesis of both the preclinical and proliferative stages of diabetic retinopathy.
Book ChapterDOI
The lymph node as a bridgehead in the metastatic dissemination of tumors.
TL;DR: The anatomical, cellular and molecular factors which play a role in metastatic dissemination and determine patterns of metastasis are reviewed, and the importance of tumor heterogeneity and the selection of metastatically competent tumor cells during systemic dissemination is explored, and it is suggested that some secondary sites are more readily colonised by metastasizing cells than others.
Journal ArticleDOI
Targeting the tumor microenvironment
TL;DR: In this paper, the authors describe some of the "druggable" targets and processes within the tumor microenvironment and review the approaches being taken to disrupt these interactions, and present a review of the approaches to disrupt them.
Journal ArticleDOI
New therapeutic targets in idiopathic pulmonary fibrosis. Aiming to rein in runaway wound-healing responses.
TL;DR: Drugs in recently completed or currently ongoing phase II and III IPF clinical trials are discussed in the context of their putative mechanisms of action and the aberrant repair processes they are believed to target: innate immune activation and polarization, fibroblast accumulation and myofibroblast differentiation, or extracellular matrix deposition and stiffening.
Journal Article
Ovarian angiogenesis. Phenotypic characterization of endothelial cells in a physiological model of blood vessel growth and regression.
TL;DR: The ovarian angiogenesis model is established as a suitable experimental system to study the functional and phenotypic properties of endothelial cells in sprouting and regressing blood vessels and provides additional evidence for the importance of endothelium cell surface glycoconjugates during angiogenic.
References
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Book
Pathologic basis of disease
TL;DR: The objective is to establish an experimental procedure and show direct AFM progression from EMT to EMT using a simple, straightforward, and reproducible procedure.
Journal ArticleDOI
Tumor cells secrete a vascular permeability factor that promotes accumulation of ascites fluid.
Donald R. Senger,Stephen J. Galli,Ann M. Dvorak,Carole A. Perruzzi,V. Susan Harvey,Harold F. Dvorak +5 more
TL;DR: Tumor ascites fluids from guinea pigs, hamsters, and mice contain activity that rapidly increases microvascular permeability, and this activity is secreted by these tumor cells and a variety of other tumor cell lines in vitro.
Book ChapterDOI
Plasminogen activators, tissue degradation, and cancer.
Keld Danø,Peter A. Andreasen,J Grøndahl-Hansen,Peter Marcus Kristensen,L.S. Nielsen,L. Skriver +5 more
TL;DR: This chapter describes two types of plasminogen activators—namely, the urokinase-type plasMinogen activator (u-PA) and the tissue- type plasmineg activator(t-PA), which are essentially different gene products.
Journal ArticleDOI
The biology of platelet-derived growth factor
TL;DR: The biology of platelet derived growth factor, it will really give you the good idea to be successful.
Journal Article
The role of the macrophage in wound repair. A study with hydrocortisone and antimacrophage serum.
Samuel Leibovich,R. Ross +1 more
TL;DR: The role of the macrophage in wound repair has been investigated by studying the healing process in wounds depleted of this cell and/or its phagocytic activity as discussed by the authors, where hydrocortisone acetate administered as a subcutaneous depot was used to induce a prolonged monocytopenia in guinea pigs, and antimacrophage serum (AMS) was used for local elimination of tissue macrophages.