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Tumors: wounds that do not heal. Similarities between tumor stroma generation and wound healing.
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Tumors of epithelioma are composed of two discrete but interdependent compartments: the malignant cells themselves and the stroma that they induce and in which they are dispersed.Abstract:
SOLID tumors are composed of two discrete but interdependent compartments: the malignant cells themselves and the stroma that they induce and in which they are dispersed.1 , 2 In tumors of epitheli...read more
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Journal ArticleDOI
Roles of neutrophils in cancer growth and progression
Maria Rosaria Galdiero,Gilda Varricchi,Stefania Loffredo,Alberto Mantovani,Alberto Mantovani,Gianni Marone +5 more
TL;DR: Increasing evidence suggests a dual role for neutrophils in modulating tumor behavior and highlights the need for a reassessment of neutrophil functions in cancer initiation and progression.
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Non-Small Cell Lung Cancer Cells Induce Monocytes to Increase Expression of Angiogenic Activity
TL;DR: The interaction between host macrophages and NSCLC cells synergistically increases angiogenic potential, and that this is due to an increased elaboration ofAngiogenic CXC chemokines.
Journal ArticleDOI
The intestine-specific homeobox gene Cdx2 decreases mobility and antagonizes dissemination of colon cancer cells.
Isabelle Gross,Isabelle Duluc,Tarek Benameur,Alexandre Calon,Elisabeth Martin,Thomas Brabletz,Michèle Kedinger,Claire Domon-Dell,Jean-Noël Freund +8 more
TL;DR: Evidence that Cdx2 antagonizes the process of tumor cell dissemination is provided, and it is suggested that this homeobox gene might represent a new therapeutic target against metastatic spreading of colon cancer.
Journal ArticleDOI
Vascular Endothelial Growth Factor and Epidermal Growth Factor Signaling Pathways as Therapeutic Targets for Colorectal Cancer
Thomas Winder,Heinz-Josef Lenz +1 more
TL;DR: The most recent data on the VEGF and EGFR signaling pathways and therapeutic reagents designed to target them are reviewed, insights into their mechanisms are provided, and results from recent clinical trials are described.
Journal ArticleDOI
The Regulation of Blood Vessel Growth by Vascular Endothelial Growth Factor
TL;DR: A recently identified family of directly-acting endothelial cell mitogens and angiogenic factors known as vascular endothelial growth factor (VEGF) or vascular permeability factor (VPF) is reviewed, pointing to VEGF as a major regulator of physiological and pathological angiogenesis.
References
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Book
Pathologic basis of disease
TL;DR: The objective is to establish an experimental procedure and show direct AFM progression from EMT to EMT using a simple, straightforward, and reproducible procedure.
Journal ArticleDOI
Tumor cells secrete a vascular permeability factor that promotes accumulation of ascites fluid.
Donald R. Senger,Stephen J. Galli,Ann M. Dvorak,Carole A. Perruzzi,V. Susan Harvey,Harold F. Dvorak +5 more
TL;DR: Tumor ascites fluids from guinea pigs, hamsters, and mice contain activity that rapidly increases microvascular permeability, and this activity is secreted by these tumor cells and a variety of other tumor cell lines in vitro.
Book ChapterDOI
Plasminogen activators, tissue degradation, and cancer.
Keld Danø,Peter A. Andreasen,J Grøndahl-Hansen,Peter Marcus Kristensen,L.S. Nielsen,L. Skriver +5 more
TL;DR: This chapter describes two types of plasminogen activators—namely, the urokinase-type plasMinogen activator (u-PA) and the tissue- type plasmineg activator(t-PA), which are essentially different gene products.
Journal ArticleDOI
The biology of platelet-derived growth factor
TL;DR: The biology of platelet derived growth factor, it will really give you the good idea to be successful.
Journal Article
The role of the macrophage in wound repair. A study with hydrocortisone and antimacrophage serum.
Samuel Leibovich,R. Ross +1 more
TL;DR: The role of the macrophage in wound repair has been investigated by studying the healing process in wounds depleted of this cell and/or its phagocytic activity as discussed by the authors, where hydrocortisone acetate administered as a subcutaneous depot was used to induce a prolonged monocytopenia in guinea pigs, and antimacrophage serum (AMS) was used for local elimination of tissue macrophages.