Journal ArticleDOI
Tumors: wounds that do not heal. Similarities between tumor stroma generation and wound healing.
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Tumors of epithelioma are composed of two discrete but interdependent compartments: the malignant cells themselves and the stroma that they induce and in which they are dispersed.Abstract:
SOLID tumors are composed of two discrete but interdependent compartments: the malignant cells themselves and the stroma that they induce and in which they are dispersed.1 , 2 In tumors of epitheli...read more
Citations
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Journal ArticleDOI
Immune control by amino acid catabolism during tumorigenesis and therapy.
TL;DR: Evidence that Trp and Arg catabolism contributes to inflammatory processes that promote tumorigenesis, impede immune responses to therapy and might promote neurological comorbidities associated with cancer is reviewed.
Journal ArticleDOI
Comparative analysis of the expression of the extracellular matrix protein tenascin in normal human fetal, adult and tumor tissues.
Pier Giorgio Natali,Maria Rita Nicotra,Aldo Bigotti,Claudio Botti,Patrizia Castellani,Anna Maria Risso,Luciano Zardi +6 more
TL;DR: This study demonstrates that TN is detectable in embryonic and fetal tissues at least from the 10th week of gestation, and has the ability to accumulate in a highly variable manner in the ECM of tumors of the same and of different histotypes.
Journal ArticleDOI
Tumor cell migration in complex microenvironments
TL;DR: In this paper, the authors discuss the factors that influence tumor cell migration with a focus on the migration of transformed carcinoma cells and highlight the benefits and shortcomings of the various assays.
Journal Article
Blockade of epidermal growth factor receptor signaling in tumor cells and tumor-associated endothelial cells for therapy of androgen-independent human prostate cancer growing in the bone of nude mice.
Sun Jin Kim,Hisanori Uehara,Takashi Karashima,David L. Shepherd,Jerald J. Killion,Isaiah J. Fidler +5 more
TL;DR: These data indicate that endothelial cells exposed to EGF produced by tumor cells express activated EGF-R and that targeting E GF-R can produce significant therapeutic effects against prostate cancer bone metastasis.
Journal ArticleDOI
Continuum model of fibroblast-driven wound contraction: inflammation-mediation.
TL;DR: A model originally proposed by Murray and co-workers is adapted to show how cell traction forces can result in spatial patterns of cell aggregates since it offers a framework for understanding how traction exerted by wound fibroblasts drives wound contraction.
References
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Book
Pathologic basis of disease
TL;DR: The objective is to establish an experimental procedure and show direct AFM progression from EMT to EMT using a simple, straightforward, and reproducible procedure.
Journal ArticleDOI
Tumor cells secrete a vascular permeability factor that promotes accumulation of ascites fluid.
Donald R. Senger,Stephen J. Galli,Ann M. Dvorak,Carole A. Perruzzi,V. Susan Harvey,Harold F. Dvorak +5 more
TL;DR: Tumor ascites fluids from guinea pigs, hamsters, and mice contain activity that rapidly increases microvascular permeability, and this activity is secreted by these tumor cells and a variety of other tumor cell lines in vitro.
Book ChapterDOI
Plasminogen activators, tissue degradation, and cancer.
Keld Danø,Peter A. Andreasen,J Grøndahl-Hansen,Peter Marcus Kristensen,L.S. Nielsen,L. Skriver +5 more
TL;DR: This chapter describes two types of plasminogen activators—namely, the urokinase-type plasMinogen activator (u-PA) and the tissue- type plasmineg activator(t-PA), which are essentially different gene products.
Journal ArticleDOI
The biology of platelet-derived growth factor
TL;DR: The biology of platelet derived growth factor, it will really give you the good idea to be successful.
Journal Article
The role of the macrophage in wound repair. A study with hydrocortisone and antimacrophage serum.
Samuel Leibovich,R. Ross +1 more
TL;DR: The role of the macrophage in wound repair has been investigated by studying the healing process in wounds depleted of this cell and/or its phagocytic activity as discussed by the authors, where hydrocortisone acetate administered as a subcutaneous depot was used to induce a prolonged monocytopenia in guinea pigs, and antimacrophage serum (AMS) was used for local elimination of tissue macrophages.