Journal ArticleDOI
Tumors: wounds that do not heal. Similarities between tumor stroma generation and wound healing.
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Tumors of epithelioma are composed of two discrete but interdependent compartments: the malignant cells themselves and the stroma that they induce and in which they are dispersed.Abstract:
SOLID tumors are composed of two discrete but interdependent compartments: the malignant cells themselves and the stroma that they induce and in which they are dispersed.1 , 2 In tumors of epitheli...read more
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The metastasis-promoting roles of tumor-associated immune cells
Heath A. Smith,Yibin Kang +1 more
TL;DR: This review focuses on the interactions between tumor cells and immune cells recruited to the tumor microenvironment and examines the factors allowing these cells to promote each stage of metastasis.
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Pretreatment neutrophil count as an independent prognostic factor in advanced non-small-cell lung cancer: an analysis of Japan Multinational Trial Organisation LC00-03.
Satoshi Teramukai,Toshiyuki Kitano,Yusuke Kishida,Masaaki Kawahara,Kaoru Kubota,K Komuta,Koichi Minato,T. Mio,Yuka Fujita,Toshiro Yonei,Kikuo Nakano,Masahiro Tsuboi,Kazuhiko Shibata,Kiyoyuki Furuse,Masanori Fukushima +14 more
TL;DR: It is confirmed that pretreatment elevated neutrophil count is an independent prognostic factor in patients with advanced NSCLC receiving modern chemotherapy, and it may be a useful indicator of patient prognosis.
Journal ArticleDOI
The extracellular matrix in tumor progression and metastasis.
Johannes A. Eble,Stephan Niland +1 more
TL;DR: This review focuses on the remodeling of the ECM under the influence of a primary solid tumor mass, primed by soluble factors of the primary tumor, which may be remodeled in a way to facilitate the engraftment of metastasizing cancer cells.
Journal ArticleDOI
VEGF-A promotes tissue repair-associated lymphatic vessel formation via VEGFR-2 and the α1β1 and α2β1 integrins
Young-Kwon Hong,Bernhard Lange-Asschenfeldt,Paula Velasco,Satoshi Hirakawa,Rainer Kunstfeld,Lawrence F. Brown,Peter Bohlen,Donald R. Senger,Michael Detmar +8 more
TL;DR: It is proposed that VEGF‐A promotes lymphatic vasculature formation via activation of VEGFR‐2 and that lineage‐specific differences of integrin receptor expression contribute to the distinct dynamics of wound‐associated angiogenesis and lymphangiogenesis.
Journal ArticleDOI
The Toll–Interleukin-1 Receptor Member SIGIRR Regulates Colonic Epithelial Homeostasis, Inflammation, and Tumorigenesis
Hui Xiao,Muhammet F. Gulen,Muhammet F. Gulen,Jinzhong Qin,Jinzhong Qin,Jianhong Yao,Katarzyna Bulek,Danielle D. Kish,Cengiz Z. Altuntas,David N Wald,Caixia Ma,Hang Zhou,Vincent K. Tuohy,Robert L. Fairchild,Carol A. de la Motte,Daniel J. Cua,Bruce A. Vallance,Xiaoxia Li +17 more
TL;DR: Gut epithelium-derived SIGIRR is critical in controlling the homeostasis and innate immune responses of the colon to enteric microflora and reduced AOM+DSS-induced tumorigenesis.
References
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Pathologic basis of disease
TL;DR: The objective is to establish an experimental procedure and show direct AFM progression from EMT to EMT using a simple, straightforward, and reproducible procedure.
Journal ArticleDOI
Tumor cells secrete a vascular permeability factor that promotes accumulation of ascites fluid.
Donald R. Senger,Stephen J. Galli,Ann M. Dvorak,Carole A. Perruzzi,V. Susan Harvey,Harold F. Dvorak +5 more
TL;DR: Tumor ascites fluids from guinea pigs, hamsters, and mice contain activity that rapidly increases microvascular permeability, and this activity is secreted by these tumor cells and a variety of other tumor cell lines in vitro.
Book ChapterDOI
Plasminogen activators, tissue degradation, and cancer.
Keld Danø,Peter A. Andreasen,J Grøndahl-Hansen,Peter Marcus Kristensen,L.S. Nielsen,L. Skriver +5 more
TL;DR: This chapter describes two types of plasminogen activators—namely, the urokinase-type plasMinogen activator (u-PA) and the tissue- type plasmineg activator(t-PA), which are essentially different gene products.
Journal ArticleDOI
The biology of platelet-derived growth factor
TL;DR: The biology of platelet derived growth factor, it will really give you the good idea to be successful.
Journal Article
The role of the macrophage in wound repair. A study with hydrocortisone and antimacrophage serum.
Samuel Leibovich,R. Ross +1 more
TL;DR: The role of the macrophage in wound repair has been investigated by studying the healing process in wounds depleted of this cell and/or its phagocytic activity as discussed by the authors, where hydrocortisone acetate administered as a subcutaneous depot was used to induce a prolonged monocytopenia in guinea pigs, and antimacrophage serum (AMS) was used for local elimination of tissue macrophages.