Journal ArticleDOI
Tumors: wounds that do not heal. Similarities between tumor stroma generation and wound healing.
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Tumors of epithelioma are composed of two discrete but interdependent compartments: the malignant cells themselves and the stroma that they induce and in which they are dispersed.Abstract:
SOLID tumors are composed of two discrete but interdependent compartments: the malignant cells themselves and the stroma that they induce and in which they are dispersed.1 , 2 In tumors of epitheli...read more
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An EGFR-ERK-SOX9 Signaling Cascade Links Urothelial Development and Regeneration to Cancer
Shizhang Ling,Xiaofei Chang,Luciana Schultz,Thomas K. Lee,Alcides Chaux,Luigi Marchionni,George J. Netto,David Sidransky,David M. Berman +8 more
TL;DR: A novel, potentially oncogenic signaling axis linking urothelial injury to UroCa is identified and inhibiting this axis is feasible through a variety of pharmacologic approaches and may have clinical utility.
Journal ArticleDOI
Adult human mesenchymal stem cells enhance breast tumorigenesis and promote hormone independence
Lyndsay V. Rhodes,Shannon E. Muir,Steven Elliott,Lori M. Guillot,James W. Antoon,Patrice Penfornis,Syreeta L. Tilghman,Virgilio A. Salvo,Juan P. Fonseca,Michelle Lacey,Barbara S. Beckman,John A. McLachlan,Brian G. Rowan,Radhika Pochampally,Matthew E. Burow +14 more
TL;DR: The relationship between tumor microenvironment and tumor growth and the progression to hormone independence are revealed and this tumor stroma-cell interaction may provide a novel target for the treatment of estrogen receptor-positive, hormone-independent, and endocrine-resistant breast carcinoma.
Journal ArticleDOI
Lymphopenia is an Independent Predictor of Inferior Outcome in Clear Cell Renal Carcinoma
TL;DR: In 430 patients with clear cell renal cell carcinoma lymphopenia was associated with lower overall survival independent of pT and TNM stages, nuclear grade, age, tobacco smoking and comorbidity index.
Journal ArticleDOI
Glioblastoma cells: a heterogeneous and fatal tumor interacting with the parenchyma.
Tercia Alves,Flavia Regina Souza Lima,Suzana Assad Kahn,Denise S. Lobo,Luiz Gustavo Dubois,Rossana C. Soletti,Helena L. Borges,Vivaldo Moura Neto +7 more
TL;DR: In this context, it is discussed how the membrane-acting toxins called cytolysins can be a potential new tool for GBM treatment.
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Pharmacologic Control of Wound Healing in Glaucoma Filtration Surgery
Moise M. Tahery,David A. Lee +1 more
TL;DR: An integrated understanding of the wound healing process, pharmacological agents, and surgical techniques are required for comprehensive treatment of wound healing in glaucoma filtration surgery.
References
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Book
Pathologic basis of disease
TL;DR: The objective is to establish an experimental procedure and show direct AFM progression from EMT to EMT using a simple, straightforward, and reproducible procedure.
Journal ArticleDOI
Tumor cells secrete a vascular permeability factor that promotes accumulation of ascites fluid.
Donald R. Senger,Stephen J. Galli,Ann M. Dvorak,Carole A. Perruzzi,V. Susan Harvey,Harold F. Dvorak +5 more
TL;DR: Tumor ascites fluids from guinea pigs, hamsters, and mice contain activity that rapidly increases microvascular permeability, and this activity is secreted by these tumor cells and a variety of other tumor cell lines in vitro.
Book ChapterDOI
Plasminogen activators, tissue degradation, and cancer.
Keld Danø,Peter A. Andreasen,J Grøndahl-Hansen,Peter Marcus Kristensen,L.S. Nielsen,L. Skriver +5 more
TL;DR: This chapter describes two types of plasminogen activators—namely, the urokinase-type plasMinogen activator (u-PA) and the tissue- type plasmineg activator(t-PA), which are essentially different gene products.
Journal ArticleDOI
The biology of platelet-derived growth factor
TL;DR: The biology of platelet derived growth factor, it will really give you the good idea to be successful.
Journal Article
The role of the macrophage in wound repair. A study with hydrocortisone and antimacrophage serum.
Samuel Leibovich,R. Ross +1 more
TL;DR: The role of the macrophage in wound repair has been investigated by studying the healing process in wounds depleted of this cell and/or its phagocytic activity as discussed by the authors, where hydrocortisone acetate administered as a subcutaneous depot was used to induce a prolonged monocytopenia in guinea pigs, and antimacrophage serum (AMS) was used for local elimination of tissue macrophages.