Journal ArticleDOI
Tumors: wounds that do not heal. Similarities between tumor stroma generation and wound healing.
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Tumors of epithelioma are composed of two discrete but interdependent compartments: the malignant cells themselves and the stroma that they induce and in which they are dispersed.Abstract:
SOLID tumors are composed of two discrete but interdependent compartments: the malignant cells themselves and the stroma that they induce and in which they are dispersed.1 , 2 In tumors of epitheli...read more
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Cancer-Associated Fibroblasts Build and Secure the Tumor Microenvironment.
TL;DR: A better understanding of the complexities ofCAF-ECM and CAF-cancer cell interactions is necessary before novel therapeutic strategies targeting the malignant tumor “soil” can be successfully implemented in the clinic.
Journal ArticleDOI
Vascular endothelial growth factor
TL;DR: A brief review of the challenges associated with the discovery of VEGF and the early steps in elucidating the role of this molecule in the regulation of angiogenesis is provided in this paper.
Journal ArticleDOI
Concise Review: Mesenchymal Stem Cells and Translational Medicine: Emerging Issues
Guangwen Ren,Guangwen Ren,Xiaodong Chen,Fengping Dong,Wenzhao Li,Xiaohui Ren,Yanyun Zhang,Yufang Shi,Yufang Shi +8 more
TL;DR: An understanding of the interaction between MSCs and the inflammatory microenvironment will provide critical information in revealing the precise in vivo mechanisms of MSC‐mediated therapeutic effects and designing more practical protocols for clinical use of these cells.
Journal ArticleDOI
Inflammation: a driving force speeds cancer metastasis.
Yadi Wu,Binhua P. Zhou +1 more
TL;DR: New insights into the molecular pathways that link inflammation in the tumor microenvironment to metastasis are reviewed, focusing on the function of proinflammatory factors, particularly cytokines during tumor metastasis.
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Targeting metastatic cancer.
TL;DR: A review of recent progress that is enabling therapeutic advances in treating both micro- and macrometastases can be found in this paper, where the authors reveal both the origins and nature of metastases and identify new opportunities for developing more effective strategies to target metastatic relapse and improve patient outcomes.
References
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Book
Pathologic basis of disease
TL;DR: The objective is to establish an experimental procedure and show direct AFM progression from EMT to EMT using a simple, straightforward, and reproducible procedure.
Journal ArticleDOI
Tumor cells secrete a vascular permeability factor that promotes accumulation of ascites fluid.
Donald R. Senger,Stephen J. Galli,Ann M. Dvorak,Carole A. Perruzzi,V. Susan Harvey,Harold F. Dvorak +5 more
TL;DR: Tumor ascites fluids from guinea pigs, hamsters, and mice contain activity that rapidly increases microvascular permeability, and this activity is secreted by these tumor cells and a variety of other tumor cell lines in vitro.
Book ChapterDOI
Plasminogen activators, tissue degradation, and cancer.
Keld Danø,Peter A. Andreasen,J Grøndahl-Hansen,Peter Marcus Kristensen,L.S. Nielsen,L. Skriver +5 more
TL;DR: This chapter describes two types of plasminogen activators—namely, the urokinase-type plasMinogen activator (u-PA) and the tissue- type plasmineg activator(t-PA), which are essentially different gene products.
Journal ArticleDOI
The biology of platelet-derived growth factor
TL;DR: The biology of platelet derived growth factor, it will really give you the good idea to be successful.
Journal Article
The role of the macrophage in wound repair. A study with hydrocortisone and antimacrophage serum.
Samuel Leibovich,R. Ross +1 more
TL;DR: The role of the macrophage in wound repair has been investigated by studying the healing process in wounds depleted of this cell and/or its phagocytic activity as discussed by the authors, where hydrocortisone acetate administered as a subcutaneous depot was used to induce a prolonged monocytopenia in guinea pigs, and antimacrophage serum (AMS) was used for local elimination of tissue macrophages.