Using imaging as a biomarker for asthma
Reads0
Chats0
TLDR
Imaging techniques can serve as a potential biomarker and be used to assess response to therapies, including newer biological treatments and bronchial thermoplasty and positron emission tomography can be useful to identify and target lung inflammation in asthmatic patients.Abstract:
There have been significant advancements in the various imaging techniques being used for the evaluation of asthmatic patients, both from a clinical and research perspective. Imaging characteristics can be used to identify specific asthmatic phenotypes and provide a more detailed understanding of endotypes contributing to the pathophysiology of the disease. Computed tomography, magnetic resonance imaging, and positron emission tomography can be used to assess pulmonary structure and function. It has been shown that specific airway and lung density measurements using computed tomography correlate with clinical parameters, including severity of disease and pathology, but also provide unique phenotypes. Hyperpolarized 129Xe and 3He are gases used as contrast media for magnetic resonance imaging that provide measurement of distal lung ventilation reflecting small-airway disease. Positron emission tomography can be useful to identify and target lung inflammation in asthmatic patients. Furthermore, imaging techniques can serve as a potential biomarker and be used to assess response to therapies, including newer biological treatments and bronchial thermoplasty.read more
Citations
More filters
Journal ArticleDOI
Toward clinically applicable biomarkers for asthma: An EAACI position paper.
Zuzana Diamant,Zuzana Diamant,Susanne J. H. Vijverberg,Kjell Alving,Arzu Bakirtas,Leif Bjermer,Adnan Custovic,Sven-Erik Dahlén,Mina Gaga,Roy Gerth van Wijk,Stefano Del Giacco,Eckard Hamelmann,Eckard Hamelmann,Liam G Heaney,Enrico Heffler,Omer Kalayci,Konstantinos Kostikas,René Lutter,Anna-Carin Olin,Svetlana Sergejeva,Angela Simpson,Peter J. Sterk,Ellen Tufvesson,Ioana Agache,Sven Seys +24 more
TL;DR: The European Academy of Allergy & Clinical Immunology Task Force on Biomarkers in Asthma was initiated to investigate clinical applicability of new and existing inflammatory biomarkers (point‐of‐care) to support diagnosis, targeted treatment, and monitoring of severe asthma.
Journal ArticleDOI
Severe bronchiolitis profiles and risk of recurrent wheeze by age 3 years
Orianne Dumas,Kohei Hasegawa,Jonathan M. Mansbach,Ashley F. Sullivan,Pedro A. Piedra,Carlos A. Camargo +5 more
TL;DR: Although longer follow‐up is needed, the results might help identify, among children hospitalized for bronchiolitis, subgroups with particularly increased risk of asthma.
Journal ArticleDOI
Single-Session Bronchial Thermoplasty Guided by 129Xe Magnetic Resonance Imaging. A Pilot Randomized Controlled Clinical Trial
Chase S. Hall,Chase S. Hall,James D. Quirk,Charles W. Goss,Daphne Lew,Jim Kozlowski,Robert P. Thomen,Jason C. Woods,Nicholas J. Tustison,John P. Mugler,Lora Gallagher,Tammy Koch,K. Schechtman,Iulian C. Ruset,F. William Hersman,Mario Castro,Mario Castro +16 more
TL;DR: Results of this pilot study suggest that similar short-term improvements with improved safety can be achieved with one BT treatment guided by 129Xe MRI when compared to standard BT.
Journal ArticleDOI
Convolutional Neural Networks with Template-Based Data Augmentation for Functional Lung Image Quantification
Nicholas J. Tustison,Brian B. Avants,Zixuan Lin,Xue Feng,Nicholas C. Cullen,Jaime F. Mata,Lucia Flors,James C. Gee,Talissa A. Altes,John P. Mugler,Kun Qing +10 more
TL;DR: An automated segmentation pipeline based on deep learning for proton lung MRI segmentation and ventilation-based quantification which improves on the previously reported methodologies in terms of computational efficiency while demonstrating accuracy and robustness is proposed.
Journal ArticleDOI
Advances in asthma in 2017: Mechanisms, biologics, and genetics
Mitchell H. Grayson,Scott Feldman,Benjamin T Prince,Priya Patel,Elizabeth C. Matsui,Andrea J. Apter +5 more
TL;DR: This review summarizes some of the most significant advances in asthma research over the past year, focusing on novel discoveries in the mechanism of asthma development and exacerbation and a discussion of potential new biomarkers, including the use of radiographic markers of disease.
References
More filters
Journal ArticleDOI
Projected cancer risks from computed tomographic scans performed in the United States in 2007.
Amy Berrington de Gonzalez,Mahadevappa Mahesh,Kwang Pyo Kim,Mythreyi Bhargavan,Mythreyi Bhargavan,Rebecca S. Lewis,Fred A. Mettler,Charles E. Land +7 more
TL;DR: These detailed estimates highlight several areas of CT scan use that make large contributions to the total cancer risk, including several scan types and age groups with a high frequency of use or scans involving relatively high doses, in which risk-reduction efforts may be warranted.
Journal ArticleDOI
Mepolizumab and Exacerbations of Refractory Eosinophilic Asthma
Pranabashis Haldar,Christopher E. Brightling,Beverley Hargadon,Sunil Gupta,W Monteiro,Ana R. Sousa,Richard P. Marshall,Peter Bradding,Ruth H. Green,Andrew J. Wardlaw,Ian D. Pavord +10 more
TL;DR: The results of this study suggest that eosinophils have a role as important effector cells in the pathogenesis of severe exacerbations of asthma in this patient population.
Journal ArticleDOI
Cluster analysis and clinical asthma phenotypes.
Pranab Haldar,Ian D. Pavord,Dominic E. Shaw,Mike A. Berry,Mike Thomas,Christopher E. Brightling,Andrew J. Wardlaw,Ruth H. Green +7 more
TL;DR: Cluster analysis offers a novel multidimensional approach for identifying asthma phenotypes that exhibit differences in clinical response to treatment algorithms, and is specific to refractory asthma.
Journal ArticleDOI
Estimating Risk of Cancer Associated With Radiation Exposure From 64-Slice Computed Tomography Coronary Angiography
TL;DR: Estimates derived from simulation models suggest that use of 64-slice CTCA is associated with a nonnegligible LAR of cancer, which varies markedly and is considerably greater for women, younger patients, and for combined cardiac and aortic scans.
Journal ArticleDOI
Recurrent CT, Cumulative Radiation Exposure, and Associated Radiation-induced Cancer Risks from CT of Adults
Aaron D. Sodickson,Pieter F. Baeyens,Katherine P. Andriole,Luciano M. Prevedello,Richard D. Nawfel,Richard Hanson,Ramin Khorasani +6 more
TL;DR: While most patients accrue low radiation-induced cancer risks, a subgroup is potentially at higher risk due to recurrent CT imaging, and Cumulative CT radiation exposure added incrementally to baseline cancer risk in the cohort.
Related Papers (5)
International ERS/ATS guidelines on definition, evaluation and treatment of severe asthma
Kian Fan Chung,Sally E. Wenzel,Jan Brozek,Andrew Bush,Mario Castro,Peter J. Sterk,Ian M. Adcock,Eric D. Bateman,Elisabeth H. Bel,Eugene R. Bleecker,Louis-Philippe Boulet,Christopher E. Brightling,Pascal Chanez,Sven-Erik Dahlén,Ratko Djukanovic,Urs Frey,Mina Gaga,Peter G. Gibson,Qutayba Hamid,Nizar N. Jajour,Thais Mauad,Ronald L. Sorkness,W. Gerald Teague +22 more