Vaccine delivery with microneedle skin patches in nonhuman primates
Peter C. DeMuth,Adrienne V. Li,Peter Abbink,Jinyan Liu,Hualin Li,Kelly Stanley,Kaitlin M. Smith,Christy L. Lavine,Michael S. Seaman,Joshua A. Kramer,Andrew D. Miller,Wuhbet Abraham,Heikyung Suh,Jamal Elkhader,Paula T. Hammond,Dan H. Barouch,Dan H. Barouch,Darrell J. Irvine +17 more
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This research presents a new, scalable, scalable and scalable approaches that allow for real-time, 3D modeling of the response of the immune system to Epstein-Barr virus.Abstract:
Peter C. DeMuth1,2, Adrienne V. Li1, Peter Abbink3, Jinyan Liu3, Hualin Li3, Kelly A. Stanley3, Kaitlin M. Smith3, Christy L. Lavine3, Michael S. Seaman3, Joshua A. Kramer4, Andrew D. Miller4, Wuhbet Abraham1,2,5, Heikyung Suh1,2,5, Jamal Elkhader1, Paula T. Hammond2,6,7, Dan H. Barouch3,8, and Darrell J. Irvine1,2,7,8,9 1Department of Biological Engineering, Massachusetts Institute of Technology (MIT), Cambridge, Massachusetts, 02139 USAread more
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Using immunotherapy to boost the abscopal effect
Wilfred Ngwa,Omoruyi Credit Irabor,Jonathan D. Schoenfeld,Jürgen Hesser,Sandra Demaria,Silvia C. Formenti +5 more
TL;DR: Evidence for this growing consensus is that combining radiotherapy with immunotherapy provides an opportunity to boost abscopal response rates, extending the use of radiotherapy to treatment of both local and metastatic disease and emerging limitations are highlighted.
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Polylactic acid (PLA) controlled delivery carriers for biomedical applications.
TL;DR: PLA's application as drug-loaded nanoparticle drug carriers, such as liposomes, polymeric nanoparticles, dendrimers, and micelles, can encapsulate otherwise toxic hydrophobic anti-tumor drugs and evade systemic toxicities.
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Synergistic Transcutaneous Immunotherapy Enhances Antitumor Immune Responses through Delivery of Checkpoint Inhibitors
TL;DR: This synergistic immunotherapy strategy locally targets the immunoinhibitory receptor programmed cell death protein 1 (PD1) and immunosuppressive enzyme indoleamine 2,3-dioxygenase (IDO) for the treatment of melanoma through a microneedle-based transcutaneous delivery approach and achieves potent antitumor efficacy.
Journal ArticleDOI
Rapidly separable microneedle patch for the sustained release of a contraceptive
TL;DR: A microneedle skin patch with rapidly separable, biodegradable polymer needles continuously releases the contraceptive levonorgestrel for over one month in rats, and was well tolerated, leaving little visible evidence of use in rats.
Journal ArticleDOI
Engineering Microneedle Patches for Vaccination and Drug Delivery to Skin
TL;DR: More advanced clinical trials and commercial-scale manufacturing will facilitate development of MNPs to realize their potential to dramatically increase patient access to otherwise-injectable drugs and to improve drug performance via skin delivery.
References
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Journal ArticleDOI
Microneedles for drug and vaccine delivery.
TL;DR: Building off a strong technology base and multiple demonstrations of successful drug delivery, microneedles are poised to advance further into clinical practice to enable better pharmaceutical therapies, vaccination and other applications.
Journal ArticleDOI
Transdermal skin delivery: predictions for humans from in vivo, ex vivo and animal models.
Biana Godin,Elka Touitou +1 more
TL;DR: Work from in vitro permeation studies to clinical performance is reviewed, presenting various experimental models used in dermal/transdermal research, including the use of excised human or animal skin, cultured skin equivalents and animals.
Journal ArticleDOI
Interfering with Resistance to Smoothened Antagonists by Inhibition of the PI3K Pathway in Medulloblastoma
Silvia Buonamici,Juliet Williams,Michael Morrissey,Anlai Wang,Ribo Guo,Anthony Vattay,Kathy Hsiao,Jing Yuan,John Green,Beatriz Ospina,Qunyan Yu,Lance Ostrom,Paul Fordjour,Dustin L. Anderson,John Monahan,Joseph Kelleher,Stefan Peukert,Shifeng Pan,Xu Wu,Sauveur Michel Maira,Carlos Garcia-Echeverria,Kimberly J. Briggs,D. Neil Watkins,Yung Mae Yao,Christoph Lengauer,Markus Warmuth,William R. Sellers,Marion Dorsch +27 more
TL;DR: By identifying a drug combination that delays or even combats development of resistance when used as a first-line treatment in clinical trials, these results could ultimately improve the lives of patients with medulloblastoma or other cancers that depend on Smo for their survival.
Journal ArticleDOI
Vaccine protection against acquisition of neutralization-resistant SIV challenges in rhesus monkeys
Dan H. Barouch,Dan H. Barouch,Jinyan Liu,Hualin Li,Lori F. Maxfield,Peter Abbink,Diana M. Lynch,M. Justin Iampietro,Adam J. SanMiguel,Michael S. Seaman,Guido Ferrari,Donald N. Forthal,Ilnour Ourmanov,Vanessa M. Hirsch,Angela Carville,Keith G. Mansfield,Donald Stablein,Maria G. Pau,Hanneke Schuitemaker,Jerald C. Sadoff,Erik Billings,Mangala Rao,Merlin L. Robb,Jerome H. Kim,Mary A. Marovich,Jaap Goudsmit,Nelson L. Michael +26 more
TL;DR: The proof-of-concept that optimized HIV-1 vaccine candidates can block acquisition of stringent, heterologous, neutralization-resistant virus challenges in rhesus monkeys is demonstrated.
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Long-Term Thermostabilization of Live Poxviral and Adenoviral Vaccine Vectors at Supraphysiological Temperatures in Carbohydrate Glass
Robert Alcock,Matthew G. Cottingham,Christine S. Rollier,Julie Furze,Samodh D. De Costa,Marian Hanlon,Alexandra J. Spencer,Jared D. Honeycutt,David H. Wyllie,Sarah C. Gilbert,Migena Bregu,Adrian V. S. Hill +11 more
TL;DR: The ability of these sugars to vitrify on desiccation to develop a thermostabilization technique for live viral vaccine vectors is exploited to create a vaccine that is effective after just one dose and that can be administered without a needle.