VirPorters: Insights into the action of cationic and histidine-rich cell-penetrating peptides.
Jana Váňová,Barbora Číhařová,Alžběta Hejtmánková,Chandra Prakash Epperla,Petr Škvára,Jitka Forstová,Marie Hubalek Kalbacova,Hana Španielová +7 more
TLDR
In this article, the authors investigated whether three cell-penetrating peptides (CPPs), namely, octa-arginine R8, polyhistidine KH27K and histidine-rich LAH4, could promote cytosolic and/or nuclear transfer of unique model nanoparticles derived from Murine polyomavirus.About:
This article is published in International Journal of Pharmaceutics.The article was published on 2022-01-01 and is currently open access. It has received 3 citations till now. The article focuses on the topics: Transduction (biophysics) & Cytosol.read more
Citations
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Endosomal escape for cell-targeted proteins. Going out after going in.
TL;DR: In this paper , the authors discuss the mechanisms intended to evade lysosomal degradation of proteins, with the most relevant examples and associated strategies, and the methods available to measure that effect.
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Application of Peptides in Construction of Nonviral Vectors for Gene Delivery
TL;DR: A review of peptide-based gene delivery systems is presented in this paper , where the current challenges and future perspectives in peptidic nonviral vectors for clinical applications are also put forward, with the aim of providing guidance towards the rational design and development of such systems.
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Application of Cell Penetrating Peptides as a Promising Drug Carrier to Combat Viral Infections
TL;DR: In this article , a review of cell penetrating peptides (CPPs) and their application as an effective drug carrier to combat viral infections is presented, which briefly describes the properties, uptake mechanisms, advantages and disadvantages, and improvement of intracellular delivery, and bioavailability of CPPs.
References
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R: A language and environment for statistical computing.
TL;DR: Copyright (©) 1999–2012 R Foundation for Statistical Computing; permission is granted to make and distribute verbatim copies of this manual provided the copyright notice and permission notice are preserved on all copies.
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The influence of endosome-disruptive peptides on gene transfer using synthetic virus-like gene transfer systems.
TL;DR: A strong correlation between pH-specific erythrocyte disruption activity and gene transfer was observed and a high-level expression of luciferase or interleukin-2 was obtained with optimized gene transfer complexes in human melanoma cells and several cell lines.
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The design and synthesis of polymers for eukaryotic membrane disruption
TL;DR: It is demonstrated that pH-sensitive synthetic polymers can be molecularly engineered to efficiently disrupt eukaryotic membranes within defined and narrow pH ranges and might serve as endosomal disruptive agents with specificities for early or late endosomes.
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Visualizing lipid-formulated siRNA release from endosomes and target gene knockdown
Anders Wittrup,Angela Ai,Xing Liu,Péter Hamar,Radiana Trifonova,Klaus Charisse,Muthiah Manoharan,Tomas Kirchhausen,Judy Lieberman +8 more
TL;DR: The ability to detect cytosolic release of siRNAs and understand how it is regulated will facilitate the development of rational strategies for improving the cytosol delivery of candidate drugs.
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Improving the endosomal escape of cell-penetrating peptides and their cargos: strategies and challenges.
TL;DR: This review surveys how CPPs labeled with chromophores can be used in combination with light to stimulate endosomal lysis and discusses the recent development of branched systems that display multiple copies of a CPP.