WNT signaling in the control of hair growth and structure.
Sarah E. Millar,Karl Willert,Patricia C. Salinas,Patricia C. Salinas,Henk Roelink,Henk Roelink,Roel Nusse,Roel Nusse,Daniel J. Sussman,Gregory S. Barsh,Gregory S. Barsh +10 more
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TLDR
A previously unrecognized role for WNT signaling in the control of hair growth and structure is demonstrated, as well as presenting the first example of a mammalian phenotype resulting from overexpression of a Dvl gene and providing an accessible in vivo system for analysis of mammalian Wnt signaling pathways.About:
This article is published in Developmental Biology.The article was published on 1999-03-01 and is currently open access. It has received 293 citations till now. The article focuses on the topics: Cuticle (hair) & Outer root sheath.read more
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Controls of hair follicle cycling.
Kurt S. Stenn,Ralf Paus +1 more
TL;DR: This review has used Chase as the model and tried to put the adult hair follicle growth cycle in perspective, and hopes that this work will serve as an introduction to basic biologists who are looking for a defined biological system that illustrates many of the challenges of modern biology.
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beta-Catenin controls hair follicle morphogenesis and stem cell differentiation in the skin.
TL;DR: It is shown that beta-catenin is required genetically downstream of tabby/downless and upstream of bmp and shh in placode formation and is essential for fate decisions of skin stem cells: in the absence of beta-Catenin, stem cells fail to differentiate into follicular keratinocytes, but instead adopt an epidermal fate.
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The biology of hair follicles.
Ralf Paus,George Cotsarelis +1 more
TL;DR: Progress in understanding of the biology and pathology of hair follicles should lead to more effective therapies for disorders of hair growth, and few drugs that are effective for these purposes are available.
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Multiple roles for activated LEF/TCF transcription complexes during hair follicle development and differentiation
Ramanuj DasGupta,Elaine Fuchs +1 more
TL;DR: It is demonstrated that LEF1/TCF3 is necessary but not sufficient for TOPGAL activation, revealing the existence of positive and negative regulators of these factors in the skin and unveiling the importance of activated LEF/ TCF complexes at distinct times in hair development and cycling when changes in cell fate and differentiation commitments take place.
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Morphogenesis and Renewal of Hair Follicles from Adult Multipotent Stem Cells
TL;DR: The results indicate that the clonogenic keratinocytes are closely related, if not identical, to the multipotent stem cells, and that the regulation of whisker growth necessitates a precise control of stem cell trafficking.
References
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Book
Molecular Cloning: A Laboratory Manual
TL;DR: Molecular Cloning has served as the foundation of technical expertise in labs worldwide for 30 years as mentioned in this paper and has been so popular, or so influential, that no other manual has been more widely used and influential.
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High resolution two-dimensional electrophoresis of proteins.
TL;DR: This technique provides a method for estimation of the number of proteins made by any biological system and can resolve proteins differing in a single charge and consequently can be used in the analysis of in vivo modifications resulting in a change in charge.
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Wnt signaling: a common theme in animal development
Ken M. Cadigan,Roel Nusse +1 more
TL;DR: Current understanding of Wnt function and signaling mechanisms is reviewed in a comparative approach, highlighting novelty and underscoring questions that remain, and putting emphasis on the latest findings.
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Mutations of the Human Homolog of Drosophila patched in the Nevoid Basal Cell Carcinoma Syndrome
Heidi Hahn,Carol Wicking,Peter G. Zaphiropoulos,Mae R. Gailani,Susan Shanley,Abirami Chidambaram,Igor Vorechovsky,Erika Holmberg,Anne Birgitte Undén,Susan Gillies,Kylie Negus,Ian M. Smyth,Carolyn Pressman,David J. Leffell,Bernard Gerrard,Alisa M. Goldstein,Michael Dean,Rune Toftgård,Georgia Chenevix-Trench,Brandon J. Wainwright,Allen E. Bale +20 more
TL;DR: It is proposed that a reduction in expression of the patched gene can lead to the developmental abnormalities observed in the syndrome and that complete loss of patched function contributes to transformation of certain cell types.
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Human Homolog of patched, a Candidate Gene for the Basal Cell Nevus Syndrome
Ronald L. Johnson,Alana L. Rothman,Jingwu Xie,Lisa V. Goodrich,John W. Bare,Jeannette M. Bonifas,Anthony G. Quinn,Richard M. Myers,David R. Cox,Ervin H. Epstein,Matthew P. Scott +10 more
TL;DR: Heritable mutations in BCNS patients and a somatic mutation in a sporadic BCC were identified in a human homolog of the Drosophila patched (ptc) gene, which appears to be crucial for proper embryonic development and for tumor suppression.