Journal ArticleDOI
YOD1 attenuates neurogenic proteotoxicity through its deubiquitinating activity
Kunikazu Tanji,Fumiaki Mori,Yasuo Miki,Jun Utsumi,Hidenao Sasaki,Akiyoshi Kakita,Hitoshi Takahashi,Koichi Wakabayashi +7 more
TLDR
The data suggest that the deubiquitinase YOD1 contributes to pathogenesis of neurodegenerative disease by decreasing ubiquitination of abnormal proteins and their subsequent degradation.About:
This article is published in Neurobiology of Disease.The article was published on 2018-01-10. It has received 18 citations till now. The article focuses on the topics: Proteotoxicity & Proteostasis.read more
Citations
More filters
Journal ArticleDOI
Ubiquitin Signaling and Degradation of Aggregate-Prone Proteins.
TL;DR: Recent studies showing that the regulation of aggregate-prone proteins by ubiquitin signaling is more complex than initially postulated are reviewed, and new information is provided about its relevance to neurodegenerative diseases and therapy.
Journal ArticleDOI
The potential roles of deubiquitinating enzymes in brain diseases.
TL;DR: This review highlights recent studies on the molecular mechanisms for deubiquitinating enzymes, and discusses potential therapeutic targets for DUBs in cases of brain diseases.
Journal ArticleDOI
The Effect of Dysfunctional Ubiquitin Enzymes in the Pathogenesis of Most Common Diseases
TL;DR: An overview of the molecular mechanism of ubiquitination and UPS is provided and the most common diseases affecting the dysfunction or dysregulation of these mechanisms are summarized.
Journal ArticleDOI
How Do Post-Translational Modifications Influence the Pathomechanistic Landscape of Huntington's Disease? A Comprehensive Review.
TL;DR: The discovery and characterization of a panoply of PTMs in HTT aggregation and cellular events in HD will bring us closer to understanding how the expression of mutant polyglutamine-containing HTT affects cellular homeostasis that leads to the perturbation of cell functions, neurotoxicity, and finally, cell death.
Journal ArticleDOI
Deubiquitinating enzymes (DUBs): decipher underlying basis of neurodegenerative diseases.
Baohua Liu,Jing Ruan,Meng Chen,Zhongding Li,Gloria M. Manjengwa,Dirk Schlüter,Weihong Song,Xu Wang,Xu Wang +8 more
TL;DR: In this paper, the deubiquitinating enzymes (DUBs) are used as fine-tuning regulators of ubiquitination and protein degradation in ND-associated pathogenic proteins including amyloid β protein, Tau, and α-synuclein.
References
More filters
Journal ArticleDOI
Staging of brain pathology related to sporadic Parkinson’s disease
TL;DR: This study traces the course of the pathology in incidental and symptomatic Parkinson cases proposing a staging procedure based upon the readily recognizable topographical extent of the lesions.
Journal ArticleDOI
The Ubiquitin System
Avram Hershko,Aaron Ciechanover +1 more
TL;DR: This review discusses recent information on functions and mechanisms of the ubiquitin system and focuses on what the authors know, and would like to know, about the mode of action of ubi...
Journal ArticleDOI
Alpha-synuclein in Lewy bodies.
Maria Grazia Spillantini,Marie L. Schmidt,Virginia M.-Y. Lee,John Q. Trojanowski,Ross Jakes,Michel Goedert +5 more
TL;DR: Strong staining of Lewy bodies from idiopathic Parkinson's disease with antibodies for α-synuclein, a presynaptic protein of unknown function which is mutated in some familial cases of the disease, indicates that the LewY bodies from these two diseases may have identical compositions.
Journal ArticleDOI
Basic Medical Research Award. The ubiquitin system.
TL;DR: The ubiquitin system plays important roles in the control of numerous processes, including cell-cycle progression, signal transduction, transcriptional regulation, receptor down-regulation, and endocytosis as mentioned in this paper.
Journal ArticleDOI
Activation of the IκB Kinase Complex by TRAF6 Requires a Dimeric Ubiquitin-Conjugating Enzyme Complex and a Unique Polyubiquitin Chain
Li Deng,Chen Wang,Erika Spencer,Liyong Yang,Amy Braun,Jianxin You,Clive A. Slaughter,Cecile M. Pickart,Zhijian J. Chen +8 more
TL;DR: It is found that TRAF6, a RING domain protein, functions together with Ubc13/Uev1A to catalyze the synthesis of unique polyubiquitin chains linked through lysine-63 (K63) of ubiquitin.