Zerumbone-loaded nanostructured lipid carriers: preparation, characterization, and antileukemic effect.
Heshu Sulaiman Rahman,Abdullah Rasedee,Chee Wun How,Ahmad Bustamam Abdul,Nazariah Allaudin Zeenathul,Hemn Hassan Othman,Mohamed Ibrahim Saeed,Swee Keong Yeap +7 more
TLDR
Zerumbone-loaded nanostructured lipid carriers (ZER-NLC) have potential as a sustained-release drug carrier system for the treatment of leukemia, according to physicochemical properties.Abstract:
Zerumbone, a natural dietary lipophilic compound with low water solubility (1.296 mg/L at 25°C) was used in this investigation. The zerumbone was loaded into nanostructured lipid carriers using a hot, high-pressure homogenization technique. The physicochemical properties of the zerumbone-loaded nanostructured lipid carriers (ZER-NLC) were determined. The ZER-NLC particles had an average size of 52.68 ± 0.1 nm and a polydispersity index of 0.29 ± 0.004 μm. Transmission electron microscopy showed that the particles were spherical in shape. The zeta potential of the ZER-NLC was −25.03 ± 1.24 mV, entrapment efficiency was 99.03%, and drug loading was 7.92%. In vitro drug release of zerumbone from ZER-NLC was 46.7%, and for a pure zerumbone dispersion was 90.5% over 48 hours, following a zero equation. Using the MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay in human T-cell acute lymphoblastic leukemia (Jurkat) cells, the half maximal inhibitory concentration (IC50) of ZER-NLC was 5.64 ± 0.38 μg/mL, and for free zerumbone was 5.39 ± 0.43 μg/mL after 72 hours of treatment. This study strongly suggests that ZER-NLC have potential as a sustained-release drug carrier system for the treatment of leukemia.read more
Citations
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Cancer prevention and therapy through the modulation of the tumor microenvironment.
Stephanie C. Casey,Amedeo Amedei,Katia Aquilano,Asfar S. Azmi,Fabian Benencia,Dipita Bhakta,Alan Bilsland,Chandra S. Boosani,Sophie Chen,Maria Rosa Ciriolo,Sarah Crawford,Hiromasa Fujii,Alexandros G. Georgakilas,Gunjan Guha,Dorota Halicka,William G. Helferich,Petr Heneberg,Kanya Honoki,W. Nicol Keith,Sid P. Kerkar,Sulma I. Mohammed,Elena Niccolai,Somaira Nowsheen,H.P. Vasantha Rupasinghe,Abbas Samadi,Neetu Singh,Wamidh H. Talib,Vasundara Venkateswaran,Richard L. Whelan,Xujuan Yang,Dean W. Felsher +30 more
TL;DR: Inhibition of targets such as cholesterol synthesis and metabolites, reactive oxygen species and hypoxia, macrophage activation and conversion, indoleamine 2,3-dioxygenase regulation of dendritic cells, vascular endothelial growth factor regulation of angiogenesis, fibrosis inhibition, endoglin, and Janus kinase signaling emerge as examples of important potential nexuses in the regulation of tumorigenesis and the tumor microenvironment that can be targeted.
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Production and characterization of nanostructured lipid carriers and solid lipid nanoparticles containing lycopene for food fortification.
TL;DR: Results of sensory analysis indicated that nanoencapsulation could obviate the poor solubility and tomato after taste of lycopene, and nanocarrier’s potential for food fortification.
Journal ArticleDOI
Targeted lung cancer therapy: preparation and optimization of transferrin-decorated nanostructured lipid carriers as novel nanomedicine for co-delivery of anticancer drugs and DNA
Zhenyu Shao,Jingyu Shao,Bingxu Tan,Shanghui Guan,Zhulong Liu,Zengjun Zhao,Fangfang He,Jian Zhao +7 more
TL;DR: It is demonstrated that Tf-PTX-DNA-NLC can achieve impressive antitumor activity and gene transfection efficiency and the novel drug and gene delivery system offers a promising strategy for the treatment of lung cancer.
Journal ArticleDOI
Potential of Zerumbone as an Anti-Cancer Agent.
Sosmitha Girisa,Bano Shabnam,Javadi Monisha,Lu Fan,Clarissa Esmeralda Halim,Frank Arfuso,Kwang Seok Ahn,Gautam Sethi,Ajaikumar B. Kunnumakkara +8 more
TL;DR: Zerumbone has shown its anti-cancer effects by causing significant suppression of proliferation, survival, angiogenesis, invasion, and metastasis through the molecular modulation of different pathways such as NF-κB, Akt, and IL-6/JAK2/STAT3 (interleukin- 6/janus kinase-2/signal transducer and activator of transcription 3) and their downstream target proteins.
Journal ArticleDOI
Recent trends in nano-based drug delivery systems for efficient delivery of phytochemicals in chemotherapy
Aruna Priyadarshini Subramanian,Saravana Kumar Jaganathan,Ayyar Manikandan,K. N. Pandiaraj,N. Gomathi,Eko Supriyanto +5 more
TL;DR: This review encourages the idea of “cancer-nanotechnology” after in-depth clinical studies on these phytochemical-loaded nanocarriers and will epitomize the nanoccarriers as a crusader in improving cancer chemotherapy by reducing undesired effects and will invigorate site-specific drug delivery.
References
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Journal ArticleDOI
Solid lipid nanoparticles (SLN) for controlled drug delivery - a review of the state of the art.
TL;DR: Relevant issues for the introduction of SLN to the pharmaceutical market, such as status of excipients, toxicity/tolerability aspects and sterilization and long-term stability including industrial large scale production are discussed.
Journal ArticleDOI
Drug delivery and nanoparticles:applications and hazards
Wim H. de Jong,Paul J A Borm +1 more
TL;DR: An overview on some of the currently used systems for drug delivery, varying from biological substances like albumin, gelatine and phospholipids for liposomes, and more substances of a chemical nature like various polymers and solid metal containing nanoparticles is provided.
Journal ArticleDOI
Solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC) in cosmetic and dermatological preparations.
TL;DR: As a novel type of lipid nanoparticles with solid matrix, the nanostructured lipid carriers (NLC) are presented and improvements discussed, for example, increase in loading capacity, physical and chemical long-term stability, triggered release and potentially supersaturated topical formulations.
Journal ArticleDOI
Lipid nanoparticles (SLN, NLC) in cosmetic and pharmaceutical dermal products.
TL;DR: An overview of the cosmetic products currently on the market is given and the improvement of the benefit/risk ratio of the topical therapy is shown and the lipid nanoparticles are a "nanosafe" carrier.
Journal ArticleDOI
Nanostructured lipid matrices for improved microencapsulation of drugs
TL;DR: A special preparation process-applicable to NLC but also SLN-allows the production of highly concentrated particle dispersions (>30-95%).
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