Journal ArticleDOI
ZFPIP/Zfp462 is involved in P19 cell pluripotency and in their neuronal fate
Julie Massé,Julie Massé,Claire Piquet-Pellorce,Justine Viet,Justine Viet,Daniel Guerrier,Daniel Guerrier,Isabelle Pellerin,Isabelle Pellerin,Stéphane Deschamps,Stéphane Deschamps +10 more
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TLDR
It is strongly suggested that ZFPIP/Zfp462 is a key chromatin factor involved in maintaining P19 pluripotency and in the early mechanisms of neural differentiation but that it is dispensable in differentiated P19 cells.About:
This article is published in Experimental Cell Research.The article was published on 2011-08-01. It has received 15 citations till now. The article focuses on the topics: Rex1 & Cell potency.read more
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A map of general and specialized chromatin readers in mouse tissues generated by label-free interaction proteomics
H. Christian Eberl,Cornelia G. Spruijt,Christian D. Kelstrup,Michiel Vermeulen,Matthias Mann +4 more
TL;DR: A sensitive, label-free histone peptide pull-down technology with extracts of different mouse tissues that defines the chromatin interaction landscape in mouse tissues and reveals a number of specialized readers in tissues such as testis.
Journal ArticleDOI
C2H2-Type Zinc Finger Proteins in Brain Development, Neurodevelopmental, and Other Neuropsychiatric Disorders: Systematic Literature-Based Analysis.
TL;DR: It is found an important tendency that poly-Z NFs and KRAB-ZNFs tend to be involved in the diseases that compromise gross brain structure and human-specific higher-order functions, respectively.
Journal ArticleDOI
Reader interactome of epigenetic histone marks in birds.
TL;DR: This initial finding suggests that despite strong conservation of the histone tail sequence, a few species‐specific differences in epigenetic readers may have evolved between birds and mammals.
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Zfp462 deficiency causes anxiety-like behaviors with excessive self-grooming in mice.
Bin Wang,Yufang Zheng,H. Shi,X. Du,Yingying Zhang,Bin Wei,Man Luo,Hong Wang,Xiaohua Wu,X. Hua,Miao Sun,Xingshun Xu +11 more
TL;DR: It is shown that Zfp462 is expressed predominantly in the developing brain, especially in the cerebral cortex and hippocampus regions from embryonic day 7.5 to early postnatal stage and causes anxiety‐like behaviors with excessive self‐grooming in mice.
Journal ArticleDOI
Zinc finger proteins orchestrate active gene silencing during embryonic stem cell differentiation.
Sojung Kwak,Tae Wan Kim,Byung Hee Kang,Jae Hwan Kim,Jang Seok Lee,Han Teo Lee,In Young Hwang,Jihoon Shin,Jong Hyuk Lee,Eun Jung Cho,Hong Duk Youn,Hong Duk Youn +11 more
TL;DR: It is suggested that some zinc finger proteins orchestrate to control the concise epigenetic states on active ESC genes during differentiation, resulting in natural lineage commitment.
References
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Journal ArticleDOI
Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors.
TL;DR: Induction of pluripotent stem cells from mouse embryonic or adult fibroblasts by introducing four factors, Oct3/4, Sox2, c-Myc, and Klf4, under ES cell culture conditions is demonstrated and iPS cells, designated iPS, exhibit the morphology and growth properties of ES cells and express ES cell marker genes.
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Induction of Pluripotent Stem Cells from Adult Human Fibroblasts by Defined Factors
Kazutoshi Takahashi,Koji Tanabe,Mari Ohnuki,Megumi Narita,Tomoko Ichisaka,Kiichiro Tomoda,Shinya Yamanaka +6 more
TL;DR: It is demonstrated that iPS cells can be generated from adult human fibroblasts with the same four factors: Oct3/4, Sox2, Klf4, and c-Myc.
Journal ArticleDOI
Induced Pluripotent Stem Cell Lines Derived from Human Somatic Cells
Junying Yu,Maxim A. Vodyanik,Kim Smuga-Otto,Jessica Antosiewicz-Bourget,Jennifer L. Frane,Shulan Tian,Jeff Nie,Gudrun A. Jonsdottir,Victor Ruotti,Ron Stewart,Igor I. Slukvin,James A. Thomson +11 more
TL;DR: This article showed that OCT4, SOX2, NANOG, and LIN28 factors are sufficient to reprogram human somatic cells to pluripotent stem cells that exhibit the essential characteristics of embryonic stem (ES) cells.
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Core transcriptional regulatory circuitry in human embryonic stem cells.
Laurie A. Boyer,Tong Ihn Lee,Megan F. Cole,Sarah E. Johnstone,Stuart S. Levine,Jacob P. Zucker,Matthew G. Guenther,Roshan M. Kumar,Heather L. Murray,Richard G. Jenner,David K. Gifford,David K. Gifford,David K. Gifford,Douglas A. Melton,Douglas A. Melton,Rudolf Jaenisch,Richard A. Young,Richard A. Young +17 more
TL;DR: Insight is provided into the transcriptional regulation of stem cells and how OCT4, SOX2, and NANOG contribute to pluripotency and self-renewal and how they collaborate to form regulatory circuitry consisting of autoregulatory and feedforward loops.
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Quantitative expression of Oct-3/4 defines differentiation, dedifferentiation or self-renewal of ES cells.
TL;DR: A role is established for Oct-3/4 as a master regulator of pluripotency that controls lineage commitment and the sophistication of critical transcriptional regulators is illustrated and the consequent importance of quantitative analyses are illustrated.