Journal ArticleDOI
Lethal-7 is down-regulated by the hepatitis B virus x protein and targets signal transducer and activator of transcription 3
Yu Wang,Yiwei Lu,Soo Ting Toh,Wing-Kin Sung,Wing-Kin Sung,Patrick Tan,Patrick Tan,Pierce K. H. Chow,Pierce K. H. Chow,Alexander Y. F. Chung,London L.P. Jooi,Caroline G.L. Lee +11 more
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TLDR
The deregulation of the expression of the let-7 family of miRNAs by HBx may represent a potential novel pathway through which HBx acts to deregulate cell proliferation leading to hepatocarcinogenesis.About:
This article is published in Journal of Hepatology.The article was published on 2010-07-01. It has received 214 citations till now. The article focuses on the topics: HBx & STAT3.read more
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Mechanisms of HBV-induced hepatocellular carcinoma
TL;DR: HBV-related HCCs may arise on non-cirrhotic livers, further supporting the notion that HBV plays a direct role in liver transformation by triggering both common and etiology specific oncogenic pathways in addition to stimulating the host immune response and driving liver chronic necro-inflammation.
Journal ArticleDOI
miR-122 – A key factor and therapeutic target in liver disease
Simonetta Bandiera,Simonetta Bandiera,Sébastien Pfeffer,Sébastien Pfeffer,Thomas F. Baumert,Thomas F. Baumert,Mirjam B. Zeisel,Mirjam B. Zeisel +7 more
TL;DR: This review summarizes the current understanding of the key role of miR-122 in liver physiology and disease and discusses the perspectives of miRNA-based therapeutic approaches for viral hepatitis and liver disease.
Journal ArticleDOI
Non-coding RNAs in hepatocellular carcinoma: molecular functions and pathological implications
TL;DR: The common deregulation of small and long nc RNAs in human HCC is summarized and the pathological roles of ncRNAs in liver carcinogenesis, epithelial-to-mesenchymal transition and HCC metastasis are reviewed and the potential applications of n cRNAs as diagnostic tools and therapeutic targets are discussed.
OtherDOI
Apoptosis and necrosis in the liver.
TL;DR: Because apoptosis is a key feature of so many diseases of the liver, therapeutic modulation of liver cell death holds promise, and a new form of "programmed" necrosis has been described: the role of necroptosis in the liver has yet to be explored.
Journal ArticleDOI
New Concepts in Cancer Biomarkers: Circulating miRNAs in Liquid Biopsies
Erika Larrea,Carla Solé,Lorea Manterola,Ibai Goicoechea,María Armesto,María Arestin,María M. Caffarel,Angela M Araujo,Maria Araiz,Marta Fernandez-Mercado,Charles H. Lawrie,Charles H. Lawrie +11 more
TL;DR: One of the most promising classes of circulating cancer biomarkers: microRNAs (miRNAs) is reviewed, which means that cancer detection may be earlier and that the ability to monitor disease progression and/or treatment response represents a paradigm shift in the treatment of cancer patients.
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Journal ArticleDOI
The functions of animal microRNAs
TL;DR: Evidence is mounting that animal miRNAs are more numerous, and their regulatory impact more pervasive, than was previously suspected.
Journal Article
Oncomirs : microRNAs with a role in cancer
TL;DR: I MicroRNAs (miRNAs) are an abundant class of small non-protein-coding RNAs that function as negative gene regulators as discussed by the authors, and have been shown to repress the expression of important cancer-related genes and might prove useful in the diagnosis and treatment of cancer.
Journal ArticleDOI
Combinatorial microRNA target predictions.
Azra Krek,Dominic Grün,Matthew N. Poy,Rachel Wolf,Lauren Rosenberg,Eric J Epstein,Philip MacMenamin,Isabelle da Piedade,Kristin C. Gunsalus,Markus Stoffel,Nikolaus Rajewsky +10 more
TL;DR: PicTar, a computational method for identifying common targets of micro RNAs, is presented and widespread coordinate control executed by microRNAs is suggested, thus providing evidence for coordinate microRNA control in mammals.
Journal ArticleDOI
RAS Is Regulated by the let-7 MicroRNA Family
Steven M. Johnson,Helge Grosshans,Jaclyn Shingara,Mike Byrom,Rich Jarvis,Angie Cheng,Emmanuel Labourier,Kristy L. Reinert,David Brown,Frank J. Slack +9 more
TL;DR: It is shown that the let-7 family negatively regulates let-60/RAS, a regulatory RNAs found in multicellular eukaryotes, including humans, where they are implicated in cancer.