Y
Yi Zhao
Researcher at University of Pennsylvania
Publications - 26
Citations - 2012
Yi Zhao is an academic researcher from University of Pennsylvania. The author has contributed to research in topics: Genome-wide association study & Medicine. The author has an hindex of 10, co-authored 20 publications receiving 1254 citations. Previous affiliations of Yi Zhao include Osaka University & Karolinska Institutet.
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Journal ArticleDOI
Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease
Rebecca Sims,Sven J. van der Lee,Adam C. Naj,Céline Bellenguez,Céline Bellenguez,Nandini Badarinarayan,Johanna Jakobsdottir,Brian W. Kunkle,Anne Boland,Rachel Raybould,Joshua C. Bis,Eden R. Martin,Benjamin Grenier-Boley,Benjamin Grenier-Boley,Stefanie Heilmann-Heimbach,Vincent Chouraki,Vincent Chouraki,Amanda B. Kuzma,Kristel Sleegers,Kristel Sleegers,Maria Vronskaya,Agustín Ruiz,Robert R. Graham,Robert Olaso,Per Hoffmann,Per Hoffmann,Megan L. Grove,Badri N. Vardarajan,Mikko Hiltunen,Markus M. Nöthen,Charles C. White,Kara L. Hamilton-Nelson,Jacques Epelbaum,Wolfgang Maier,Wolfgang Maier,Seung Hoan Choi,Gary W. Beecham,Cécile Dulary,Stefan Herms,Stefan Herms,Albert V. Smith,Cory C. Funk,Céline Derbois,Andreas J. Forstner,Shahzad Ahmad,Hong-Dong Li,Delphine Bacq,Denise Harold,Claudia L. Satizabal,Claudia L. Satizabal,Otto Valladares,Alessio Squassina,Rhodri Thomas,Jennifer A. Brody,Liming Qu,Pascual Sánchez-Juan,Taniesha Morgan,Frank J. Wolters,Yi Zhao,Florentino Sanchez Garcia,Nicola Denning,Myriam Fornage,John Malamon,Maria Candida Deniz Naranjo,Elisa Majounie,Thomas H. Mosley,Beth A. Dombroski,David Wallon,Michelle K. Lupton,Michelle K. Lupton,Josée Dupuis,Patrice L. Whitehead,Laura Fratiglioni,Laura Fratiglioni,Christopher Medway,Xueqiu Jian,Shubhabrata Mukherjee,Lina Keller,Kristelle Brown,Honghuang Lin,Laura B. Cantwell,Francesco Panza,Bernadette McGuinness,Sonia Moreno-Grau,Jeremy D. Burgess,Vincenzo Solfrizzi,Petra Proitsi,Hieab H.H. Adams,Mariet Allen,Davide Seripa,Pau Pastor,L. Adrienne Cupples,L. Adrienne Cupples,Nathan D. Price,Didier Hannequin,Ana Frank-García,Ana Frank-García,Daniel Levy,Daniel Levy,Paramita Chakrabarty,Paolo Caffarra,Paolo Caffarra,Ina Giegling,Alexa S. Beiser,Alexa S. Beiser,Vilmantas Giedraitis,Harald Hampel,Harald Hampel,Melissa E. Garcia,Xue Wang,Lars Lannfelt,Patrizia Mecocci,Gudny Eiriksdottir,Paul K. Crane,Florence Pasquier,Florence Pasquier,Virginia Boccardi,Isabel Henández,Robert Barber,Martin Scherer,Lluís Tárraga,Perrie M. Adams,Markus Leber,Yuning Chen,Marilyn S. Albert,Steffi G. Riedel-Heller,Valur Emilsson,Duane Beekly,Anne Braae,Reinhold Schmidt,Deborah Blacker,Carlo Masullo,Helena Schmidt,Rachelle S. Doody,Gianfranco Spalletta,W. T. Longstreth,Thomas Fairchild,Paola Bossù,Oscar L. Lopez,Matthew P. Frosch,Eleonora Sacchinelli,Bernardino Ghetti,Qiong Yang,Ryan M. Huebinger,Frank Jessen,Frank Jessen,Frank Jessen,Shuo Li,M. Ilyas Kamboh,John C. Morris,Oscar Sotolongo-Grau,Mindy J. Katz,Chris Corcoran,Melanie L. Dunstan,Amy Braddel,Charlene Thomas,Alun Meggy,Rachel Marshall,Amy Gerrish,Jade Chapman,Miquel Aguilar,Sarah Taylor,Matt Hill,Monica Diez Fairen,Angela Hodges,Bruno Vellas,Hilkka Soininen,Iwona Kłoszewska,Makrina Daniilidou,James Uphill,Yogen Patel,Joseph T. Hughes,Jenny Lord,James Turton,Annette M. Hartmann,Roberta Cecchetti,Chiara Fenoglio,Maria Serpente,Marina Arcaro,Carlo Caltagirone,Maria Donata Orfei,Antonio Ciaramella,Sabrina Pichler,Manuel Mayhaus,Wei Gu,Alberto Lleó,Juan Fortea,Rafael Blesa,Imelda Barber,Keeley J. Brookes,Chiara Cupidi,Raffaele Maletta,David Carrell,Sandro Sorbi,Susanne Moebus,Maria Urbano,Alberto Pilotto,Johannes Kornhuber,Paolo Bosco,Stephen Todd,David Craig,Janet A. Johnston,Michael Gill,Brian A. Lawlor,Aoibhinn Lynch,Nick C. Fox,John Hardy,Roger L. Albin,Liana G. Apostolova,Liana G. Apostolova,Liana G. Apostolova,Steven E. Arnold,Sanjay Asthana,Craig S. Atwood,Clinton T. Baldwin,Lisa L. Barnes,Sandra Barral,Thomas G. Beach,James T. Becker,Eileen H. Bigio,Thomas D. Bird,Bradley F. Boeve,James Bowen,Adam L. Boxer,James R. Burke,Jeffrey M. Burns,Joseph D. Buxbaum,Nigel J. Cairns,Chuanhai Cao,Christopher S. Carlson,Cynthia M. Carlsson,Regina M. Carney,Minerva M. Carrasquillo,Steven L. Carroll,Carolina Ceballos Diaz,Helena C. Chui,David G. Clark,David G. Clark,David H. Cribbs,Elizabeth Crocco,Charles DeCarli,Malcolm B. Dick,Ranjan Duara,Denis A. Evans,Kelley Faber,Kenneth B. Fallon,David W. Fardo,Martin R. Farlow,Steven H. Ferris,Tatiana Foroud,Douglas Galasko,Marla Gearing,Daniel H. Geschwind,John R. Gilbert,Neill R. Graff-Radford,Robert C. Green,John H. Growdon,Ronald L. Hamilton,Lindy E. Harrell,Lawrence S. Honig,Matthew J. Huentelman,Christine M. Hulette,Bradley T. Hyman,Gail P. Jarvik,Erin L. Abner,Lee-Way Jin,Gyungah Jun,Anna Karydas,Jeffrey Kaye,Jeffrey Kaye,Ronald C. Kim,Neil W. Kowall,Joel H. Kramer,Frank M. LaFerla,James J. Lah,James B. Leverenz,Allan I. Levey,Ge Li,Andrew P. Lieberman,Kathryn L. Lunetta,Constantine G. Lyketsos,Daniel C. Marson,Frank Martiniuk,Deborah C. Mash,Eliezer Masliah,Wayne C. McCormick,Susan M. McCurry,Andrew McDavid,Ann C. McKee,M.-Marsel Mesulam,Bruce L. Miller,Carol A. Miller,Joshua W. Miller,Jill R. Murrell,Amanda J. Myers,Sid E. O'Bryant,John M Olichney,Vernon S. Pankratz,Joseph E. Parisi,Henry L. Paulson,William Perry,Elaine R. Peskind,Aimee Pierce,Wayne W. Poon,Huntington Potter,Joseph F. Quinn,Joseph F. Quinn,Ashok Raj,Murray A. Raskind,Barry Reisberg,Christiane Reitz,John M. Ringman,Erik D. Roberson,Ekaterina Rogaeva,Howard J. Rosen,Roger N. Rosenberg,Mark A. Sager,Andrew J. Saykin,Julie A. Schneider,Lon S. Schneider,William W. Seeley,Amanda Smith,Joshua A. Sonnen,Salvatore Spina,Robert S. Stern,Russell H. Swerdlow,Rudolph E. Tanzi,Tricia A. Thornton-Wells,John Q. Trojanowski,Juan C. Troncoso,Vivianna M. Van Deerlin,Linda J. Van Eldik,Harry V. Vinters,Jean Paul G. Vonsattel,Sandra Weintraub,Kathleen A. Welsh-Bohmer,Kirk C. Wilhelmsen,Jennifer Williamson,Thomas S. Wingo,Randall L. Woltjer,Clinton B. Wright,Chang En Yu,Lei Yu,Fabienne Garzia,Feroze Golamaully,Gislain Septier,Sebastien Engelborghs,Rik Vandenberghe,Peter Paul De Deyn,Carmen Muñoz Fernadez,Yoland Aladro Benito,Håkan Thonberg,Charlotte Forsell,Lena Lilius,Anne Kinhult-Ståhlbom,Lena Kilander,RoseMarie Brundin,Letizia Concari,Letizia Concari,Seppo Helisalmi,Anne M. Koivisto,Annakaisa Haapasalo,Vincent Dermecourt,Nathalie Fievet,Olivier Hanon,Carole Dufouil,Carole Dufouil,Alexis Brice,Alexis Brice,Karen Ritchie,Bruno Dubois,Bruno Dubois,Jayanadra J. Himali,C. Dirk Keene,JoAnn T. Tschanz,Annette L. Fitzpatrick,Walter A. Kukull,Maria C. Norton,Thor Aspelund,Eric B. Larson,Eric B. Larson,Ronald G. Munger,Jerome I. Rotter,Richard B. Lipton,María J. Bullido,María J. Bullido,Albert Hofman,Thomas J. Montine,Eliecer Coto,Eric Boerwinkle,Eric Boerwinkle,Ronald C. Petersen,Victoria Alvarez,Fernando Rivadeneira,Eric M. Reiman,Maura Gallo,Christopher J. O'Donnell,Joan S. Reisch,Amalia C. Bruni,Donald R. Royall,Martin Dichgans,Martin Dichgans,Mary Sano,Daniela Galimberti,Peter St George-Hyslop,Peter St George-Hyslop,Elio Scarpini,Debby W. Tsuang,Michelangelo Mancuso,Ubaldo Bonuccelli,Ashley R. Winslow,Antonio Daniele,Chuang Kuo Wu,Oliver Peters,Benedetta Nacmias,Matthias Riemenschneider,Reinhard Heun,Carol Brayne,David C. Rubinsztein,Jose Bras,Jose Bras,Rita Guerreiro,Rita Guerreiro,Ammar Al-Chalabi,Christopher Shaw,John Collinge,David G. Mann,David G. Mann,Jordi Clarimón,Rebecca Sussams,Simon Lovestone,Michael Conlon O'Donovan,Michael John Owen,Timothy W. Behrens,Simon Mead,André G. Uitterlinden,André G. Uitterlinden,Carlos Cruchaga,Martin Ingelsson,David A. Bennett,John Powell,Todd E. Golde,Caroline Graff,Philip L. De Jager,Kevin Morgan,Nilufer Ertekin-Taner,Onofre Combarros,Bruce M. Psaty,Peter Passmore,Steven G. Younkin,Claudine Berr,Vilmundur Gudnason,Dan Rujescu,Dennis W. Dickson,Jean-François Dartigues,Anita L. DeStefano,Anita L. DeStefano,Sara Ortega-Cubero,Hakon Hakonarson,Dominique Campion,Mercè Boada,John K Kauwe,Lindsay A. Farrer,Christine Van Broeckhoven,Christine Van Broeckhoven,M. Arfan Ikram,Lesley Jones,Jonathan L. Haines,Christophe Tzourio,Lenore J. Launer,Lenore J. Launer,Valentina Escott-Price,Richard Mayeux,Jean-François Deleuze,Najaf Amin,Alison Goate,Margaret A. Pericak-Vance,Peter Holmans,Cornelia M. van Duijn,Alfredo Ramirez,Alfredo Ramirez,Li-San Wang,Jean-Charles Lambert,Jean-Charles Lambert,Sudha Seshadri,Sudha Seshadri,Julie Williams,Gerard D. Schellenberg +487 more
TL;DR: Three new genome-wide significant nonsynonymous variants associated with Alzheimer's disease are observed, providing additional evidence that the microglia-mediated innate immune response contributes directly to the development of Alzheimer's Disease.
Journal ArticleDOI
New insights into the genetic etiology of Alzheimer’s disease and related dementias
Céline Bellenguez,Fahri Küçükali,Iris E. Jansen,Luca Kleineidam,Sonia Moreno-Grau,Najaf Amin,Adam C. Naj,R. Campos-Martín,Benjamin Grenier-Boley,Víctor Andrade,Peter Holmans,Anne Boland,Vincent Damotte,S. J. van der Lee,Marcos R. Costa,Teemu Kuulasmaa,Qiong Yang,Itziar de Rojas,Joshua C. Bis,Amber Yaqub,Ivana Prokic,Julien Chapuis,Shahzad Ahmad,Vilmantas Giedraitis,Dag Aarsland,Carla Abdelnour,Emilio Alarcón-Martín,Daniel Alcolea,Montserrat Alegret,Ignacio Alvarez,Victoria Alvarez,Nicola J. Armstrong,Anthoula Tsolaki,Carmen Antúnez,Ildebrando Appollonio,Marina Arcaro,Silvana Archetti,Alfonso Arias Pastor,Beatrice Arosio,Lavinia Athanasiu,Henri Bailly,Nerisa Banaj,Miquel Baquero,Sandra Barral,Alexa S. Beiser,Ana Pastor,Jennifer E. Below,Penny Benchek,Luisa Benussi,Claudine Berr,Céline Besse,Valentina Bessi,Giuliano Binetti,Alessandra Bizarro,Rafael Blesa,Mercè Boada,Eric Boerwinkle,S. Borroni,Silvia Boschi,Paola Bossù,Geir Bråthen,Jan Bressler,Catherine Bresner,Henry Brodaty,Keeley J. Brookes,Luis I. Brusco,Dolores Buiza-Rueda,Katharina Bürger,Vanessa Burholt,William S. Bush,Miguel Calero,Laura B. Cantwell,Geneviève Chêne,Jaeyoon Chung,Michael L. Cuccaro,Angel Carracedo,Roberta Cecchetti,Laura Cervera-Carles,Camille Charbonnier,Hung-Hsin Chen,Caterina Chillotti,Simona Ciccone,Jurgen A.H.R. Claassen,Christopher M. Clark,Elisa Conti,Anaïs Corma-Gómez,Emanuele Maria Costantini,Carlo Custodero,D. Daian,Maria Carolina Dalmasso,Antonio Daniele,Efthimios Dardiotis,Jean-François Dartigues,Peter Paul De Deyn,Katia de Paiva Lopes,Lot de Witte,Stéphanie Debette,Jürgen Deckert,Teodoro Del Ser,Nicola Denning,Anita L. DeStefano,Martin Dichgans,Janine Diehl-Schmid,Monica Diez-Fairen,Paolo Rosso,Srdjan Djurovic,Emmanuelle Duron,Emrah Düzel,Carole Dufouil,Gudny Eiriksdottir,Sebastiaan Engelborghs,Valentina Escott-Price,Ana Espinosa,Michael Ewers,Kelley Faber,Tagliavini Fabrizio,Sune F. Nielsen,David W. Fardo,Lucia Farotti,Chiara Fenoglio,Marta Fernández-Fuertes,Raffaele Ferrari,Catarina Beatriz Silva Ferreira,Evelyn Ferri,Bertrand Fin,Peter Fischer,Tormod Fladby,Klaus Fliessbach,Bernard Fongang,Myriam Fornage,Juan Fortea,Tatiana Foroud,Silvia Fostinelli,Nick C. Fox,Emilio Franco-Macías,María J. Bullido,Ana Frank-García,Lutz Froelich,Brian Fulton-Howard,Daniela Galimberti,José María García-Alberca,Pablo Garcia-Gonzalez,Sebastián García-Madrona,Guillermo García-Ribas,Roberta Ghidoni,Ina Giegling,Giaccone Giorgio,Alison Goate,Oliver Goldhardt,Duber Gomez-Fonseca,Antonio González-Pérez,Caroline Graff,Giulia Grande,Emma Green,Timo Grimmer,Edna Grünblatt,Michelle Grunin,Vilmundur Gudnason,Tamar Guetta-Baranes,Annakaisa Haapasalo,Georgios M. Hadjigeorgiou,Jonathan L. Haines,Kara L. Hamilton-Nelson,Harald Hampel,Olivier Hanon,John Hardy,T. Hartmann,Lucrezia Hausner,Janet C Harwood,Stefanie Heilmann-Heimbach,Seppo Helisalmi,Michael T. Heneka,Isabel Hernández,Martin J. Herrmann,Per Hoffmann,Clive Holmes,Henne Holstege,Raquel Huerto Vilas,Marc Hulsman,Jack Humphrey,Geert Jan Biessels,Xueqiu Jian,Charlotte Johansson,Gyungah Jun,Y. Kastumata,John S. K. Kauwe,Patrick G. Kehoe,Lena Kilander,Anne Kinhult Ståhlbom,Miia Kivipelto,Anne M. Koivisto,Johannes Kornhuber,Mary H. Kosmidis,Walter A. Kukull,Pavel P. Kuksa,Brian W. Kunkle,Amanda B. Kuzma,Carmen Lage,Erika J. Laukka,Lenore J. Launer,Alessandra Lauria,Chien‐Yueh Lee,Jenni Lehtisalo,Ondrej Lerch,Alberto Lleó,W. T. Longstreth,Oscar L. Lopez,Adolfo López de Munain,Seth Love,Malin Löwemark,L. Luckcuck,Kathryn L. Lunetta,Yiyi Ma,Juan Macías,Catherine A. MacLeod,Wolfgang Mader,Francesca Mangialasche,Marco Spallazzi,Marta Marquié,Rachel Marshall,Eden R. Martin,Angel Martin Montes,Carmen Martinez Rodriguez,Carlo Masullo,Richard Mayeux,Simon Head,Patrizia Mecocci,Miguel Medina,Alun Meggy,Shima Mehrabian,Silvia Mendoza,Manuel Menéndez-González,Pablo Mir,Susanne Moebus,Merel O. Mol,Laura Molina-Porcel,Laura Montrreal,Laura Morelli,Fermin Moreno,Kevin Morgan,Thomas H. Mosley,Markus M. Nöthen,Carolina Muchnik,Shubhabrata Mukherjee,Benedetta Nacmias,Tiia Ngandu,Gaël Nicolas,Børge G. Nordestgaard,Robert Olaso,Adelina Orellana,Michela Orsini,G. Ortega,Alessandro Padovani,Caffarra Paolo,Goran Papenberg,Lucilla Parnetti,Florence Pasquier,Pau Pastor,Gina M. Peloso,Alba Pérez-Cordón,Jordi Pérez-Tur,Pierre Pericard,Oliver Peters,Yolande A.L. Pijnenburg,Juan A. Pineda,Gerard Piñol-Ripoll,Claudia Pisanu,Thomas Polak,Julius Popp,Danielle Posthuma,Josef Priller,Raquel Delgado Puerta,Olivier Quenez,Inés Quintela,Jesper Qvist Thomassen,Alberto Rábano,Innocenzo Rainero,Farid Rajabli,Inez H.G.B. Ramakers,Luis Miguel Real,Marcel J. T. Reinders,Christiane Reitz,Dolly Reyes-Dumeyer,Perry G. Ridge,Steffi G. Riedel-Heller,Peter Riederer,Natalia Roberto,Eloy Rodríguez-Rodríguez,Arvid Rongve,I. Allende,Maitée Rosende-Roca,Jose Luis Royo,Elisa Rubino,Dan Rujescu,María Eugenia Sáez,Paraskevi Sakka,Ingvild Saltvedt,Angela Sanabria,M B Sánchez-Arjona,Florentino Sanchez-Garcia,Pascual Sanchez Juan,Raquel Sánchez-Valle,Sigrid Botne Sando,Chloé Sarnowski,Claudia L. Satizabal,Michela Scamosci,Nikolaos Scarmeas,Elio Scarpini,Philip Scheltens,Norbert Scherbaum,Martin Scherer,Matthias Schmid,Anja Schneider,Jonathan M. Schott,Geir Selbæk,Davide Seripa,Manuel Serrano,Jin Sha,Alexey A. Shadrin,Olivia Anna Skrobot,Susan Slifer,G. Snijders,Hilkka Soininen,Vincenzo Solfrizzi,Alina Solomon,Yeunjoo E. Song,Sandro Sorbi,Oscar Sotolongo-Grau,Gianfranco Spalletta,Annika Spottke,Alessio Squassina,Eystein Stordal,Juan Pablo Tartan,Lluís Tárraga,Niccolò Tesi,Anbupalam Thalamuthu,Tegos Thomas,Giuseppe Tosto,Latchezar Traykov,Lucio Tremolizzo,Anne Tybjærg-Hansen,André G. Uitterlinden,Abbe Ullgren,Ingun Ulstein,Sergi Valero,Otto Valladares,Christine Van Broeckhoven,Jeffery M. Vance,Badri N. Vardarajan,Aad Van Der Lugt,Jasper Van Dongen,Jeroen van Rooij,John C. van Swieten,Rik Vandenberghe,Frans R.J. Verhey,Jean-Sébastien Vidal,Jonathan Vogelgsang,Martin Vyhnalek,Michael Wagner,David Wallon,Li-San Wang,Ruiqi Wang,Leonie Weinhold,Jens Wiltfang,Gill Windle,Bob Woods,Mary Yannakoulia,Habil Zare,Yi Zhao,Xiaoling Zhang,Congcong Zhu,Miren Zulaica,Lindsay A. Farrer,Bruce M. Psaty,Mohsen Ghanbari,Towfique Raj,Perminder S. Sachdev,Karen A. Mather,Frank Jessen,M. Arfan Ikram,Alexandre de Mendonça,Jakub Hort,Magda Tsolaki,Margaret A. Pericak-Vance,Philippe Amouyel,Julie Williams,Ruth Frikke-Schmidt,Jordi Clarimón,Jean-François Deleuze,Giacomina Rossi,Sudha Seshadri,Ole A. Andreassen,Martin Ingelsson,Mikko Hiltunen,Kristel Sleegers,Gerard D. Schellenberg,Cornelia M. van Duijn,Rebecca Sims,Wiesje M. van der Flier,Agustín Ruiz,Alfredo Ramirez,Jean-Charles Lambert +401 more
TL;DR: This paper performed a two-stage genome-wide association study with 111,326 clinically diagnosed/proxy AD cases and 677,663 controls and found 75 risk loci, of which 42 were new at the time of analysis.
Journal ArticleDOI
A statistical framework for cross-tissue transcriptome-wide association analysis.
Yiming Hu,Mo Li,Qiongshi Lu,Haoyi Weng,Jiawei Wang,Seyedeh M. Zekavat,Seyedeh M. Zekavat,Seyedeh M. Zekavat,Zhaolong Yu,Boyang Li,Jianlei Gu,Sydney Muchnik,Yu Shi,Brian W. Kunkle,Shubhabrata Mukherjee,Pradeep Natarajan,Adam C. Naj,Amanda B. Kuzma,Yi Zhao,Paul K. Crane,Hui Lu,Hongyu Zhao +21 more
TL;DR: A summary-statistic-based testing framework that combines multiple single-tissue associations into a powerful metric to quantify the overall gene–trait association is described and applied to multiple genome-wide-association results.
Journal ArticleDOI
Whole exome sequencing study identifies novel rare and common Alzheimer's-Associated variants involved in immune response and transcriptional regulation
Joshua C. Bis,Xueqiu Jian,Brian W. Kunkle,Yuning Chen,Kara L. Hamilton-Nelson,William S. Bush,William J Salerno,Daniel Lancour,Yiyi Ma,Alan E. Renton,Edoardo Marcora,John J. Farrell,Yi Zhao,Liming Qu,Shahzad Ahmad,Najaf Amin,Philippe Amouyel,Philippe Amouyel,Philippe Amouyel,Gary W. Beecham,Jennifer E. Below,Dominique Campion,Laura B. Cantwell,Camille Charbonnier,Jaeyoon Chung,Paul K. Crane,Carlos Cruchaga,L. Adrienne Cupples,Jean-François Dartigues,Stéphanie Debette,Jean-François Deleuze,Lucinda Fulton,Stacey Gabriel,Emmanuelle Génin,Richard A. Gibbs,Alison Goate,Benjamin Grenier-Boley,Namrata Gupta,Jonathan L. Haines,Aki S. Havulinna,Aki S. Havulinna,Seppo Helisalmi,Mikko Hiltunen,Daniel P. Howrigan,Daniel P. Howrigan,M. Arfan Ikram,Jaakko Kaprio,Jan Konrad,Amanda B. Kuzma,Eric S. Lander,Mark Lathrop,Terho Lehtimäki,Honghuang Lin,Kari Mattila,Richard Mayeux,Donna M. Muzny,Waleed Nasser,Benjamin M. Neale,Benjamin M. Neale,Kwangsik Nho,Gaël Nicolas,Devanshi Patel,Margaret A. Pericak-Vance,Markus Perola,Markus Perola,Markus Perola,Bruce M. Psaty,Olivier Quenez,Farid Rajabli,Richard Redon,Christiane Reitz,Anne M. Remes,Anne M. Remes,Veikko Salomaa,Chloé Sarnowski,Helena Schmidt,Michael A. Schmidt,Reinhold Schmidt,Hilkka Soininen,Timothy A. Thornton,Giuseppe Tosto,Christophe Tzourio,Sven J. van der Lee,Cornelia M. van Duijn,Otto Valladares,Badri N. Vardarajan,Li-San Wang,Weixin Wang,Ellen M. Wijsman,Richard K. Wilson,Daniela Witten,Kim C. Worley,Xiaoling Zhang,Alzheimer’s Disease Sequencing,Alzheimer’s Disease Sequencing,Alzheimer’s Disease Sequencing,Céline Bellenguez,Jean-Charles Lambert,Mitja I. Kurki,Mitja I. Kurki,Mitja I. Kurki,Aarno Palotie,Aarno Palotie,Aarno Palotie,Mark J. Daly,Mark J. Daly,Mark J. Daly,Eric Boerwinkle,Eric Boerwinkle,Kathryn L. Lunetta,Anita L. DeStefano,Josée Dupuis,Eden R. Martin,Gerard D. Schellenberg,Sudha Seshadri,Sudha Seshadri,Adam C. Naj,Myriam Fornage,Lindsay A. Farrer +118 more
TL;DR: The Alzheimer’s Disease Sequencing Project undertook whole exome sequencing in 5,740 late-onset Alzheimer disease cases and 5,096 cognitively normal controls primarily of European ancestry, identifying novel and predicted functional genetic variants in genes previously associated with AD.