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Anastasia Baryshnikova
Researcher at Princeton University
Publications - 57
Citations - 8030
Anastasia Baryshnikova is an academic researcher from Princeton University. The author has contributed to research in topics: Gene & Synthetic genetic array. The author has an hindex of 29, co-authored 55 publications receiving 7054 citations. Previous affiliations of Anastasia Baryshnikova include University of Milan & University of Toronto.
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Journal ArticleDOI
The genetic landscape of a cell.
Michael Costanzo,Anastasia Baryshnikova,Jeremy Bellay,Yungil Kim,Eric D. Spear,Carolyn S. Sevier,Huiming Ding,Judice L. Y. Koh,Kiana Toufighi,Sara Mostafavi,Jeany Prinz,Robert P. St.Onge,Benjamin VanderSluis,Taras Makhnevych,Franco J. Vizeacoumar,Solmaz Alizadeh,Sondra Bahr,Renee L. Brost,Yiqun Chen,Murat Cokol,Raamesh Deshpande,Zhijian Li,Zhen Yuan Lin,Wendy Liang,Michaela Marback,Jadine Paw,Bryan Joseph San Luis,Ermira Shuteriqi,Amy Hin Yan Tong,Nydia Van Dyk,Iain M. Wallace,Joseph Whitney,Matthew T. Weirauch,Guoqing Zhong,Hongwei Zhu,Walid A. Houry,Michael Brudno,Sasan Ragibizadeh,Balázs Papp,Csaba Pál,Frederick P. Roth,Guri Giaever,Corey Nislow,Olga G. Troyanskaya,Howard Bussey,Gary D. Bader,Anne-Claude Gingras,Quaid Morris,Philip M. Kim,Chris A. Kaiser,Chad L. Myers,Brenda J. Andrews,Charles Boone +52 more
TL;DR: A network based on genetic interaction profiles reveals a functional map of the cell in which genes of similar biological processes cluster together in coherent subsets, and highly correlated profiles delineate specific pathways to define gene function.
Journal ArticleDOI
A global genetic interaction network maps a wiring diagram of cellular function
Michael Costanzo,Benjamin VanderSluis,Elizabeth N. Koch,Anastasia Baryshnikova,Carles Pons,Guihong Tan,Wen Wang,Matej Usaj,Julia Hanchard,Susan D. Lee,Vicent Pelechano,Erin B. Styles,Maximilian Billmann,Jolanda van Leeuwen,Nydia Van Dyk,Zhen Yuan Lin,Elena Kuzmin,Justin Nelson,Jeff S. Piotrowski,Tharan Srikumar,Sondra Bahr,Yiqun Chen,Raamesh Deshpande,Christoph F. Kurat,Sheena C. Li,Zhijian Li,Mojca Mattiazzi Usaj,Hiroki Okada,Natasha Pascoe,Bryan Joseph San Luis,Sara Sharifpoor,Emira Shuteriqi,Scott W. Simpkins,Jamie Snider,Harsha Garadi Suresh,Yizhao Tan,Hongwei Zhu,Noël Malod-Dognin,Vuk Janjić,Natasa Przulj,Natasa Przulj,Olga G. Troyanskaya,Igor Stagljar,Tian Xia,Tian Xia,Yoshikazu Ohya,Anne-Claude Gingras,Brian Raught,Michael Boutros,Lars M. Steinmetz,Lars M. Steinmetz,Claire Moore,Adam P. Rosebrock,Amy A. Caudy,Chad L. Myers,Brenda J. Andrews,Charles Boone +56 more
TL;DR: A global genetic interaction network highlights the functional organization of a cell and provides a resource for predicting gene and pathway function and how coherent sets of negative or positive genetic interactions connect protein complex and pathways to map a functional wiring diagram of the cell.
Journal ArticleDOI
Systematic exploration of essential yeast gene function with temperature-sensitive mutants
Zhijian Li,Franco J. Vizeacoumar,Sondra Bahr,Jingjing Li,Jonas Warringer,Frederick S. Vizeacoumar,Renqiang Min,Benjamin VanderSluis,Jeremy Bellay,Michael Devit,James A. Fleming,Andrew D. Stephens,Julian Haase,Zhen Yuan Lin,Anastasia Baryshnikova,Hong Lu,Zhun Yan,Ke Jin,Sarah L. Barker,Alessandro Datti,Alessandro Datti,Guri Giaever,Corey Nislow,Chris Bulawa,Chad L. Myers,Michael Costanzo,Anne-Claude Gingras,Zhaolei Zhang,Anders Blomberg,Kerry Bloom,Brenda J. Andrews,Charles Boone +31 more
TL;DR: This mutant collection should facilitate a wide range of systematic studies aimed at understanding the functions of essential genes, including roles for cohesin and condensin genes in spindle disassembly.
Journal ArticleDOI
Quantitative analysis of fitness and genetic interactions in yeast on a genome scale
Anastasia Baryshnikova,Michael Costanzo,Yungil Kim,Huiming Ding,Judice L. Y. Koh,Kiana Toufighi,Ji-Young Youn,Jiongwen Ou,Bryan Joseph San Luis,Sunayan Bandyopadhyay,Matthew A. Hibbs,David C. Hess,Anne-Claude Gingras,Gary D. Bader,Olga G. Troyanskaya,Grant W. Brown,Brenda J. Andrews,Charles Boone,Chad L. Myers +18 more
TL;DR: This work has applied the SGA score to examine the relationship between physical and genetic interaction networks, and found that positive genetic interactions connect across functionally distinct protein complexes revealing a network of genetic suppression among loss-of-function alleles.
Journal ArticleDOI
Rad51-dependent DNA structures accumulate at damaged replication forks in sgs1 mutants defective in the yeast ortholog of BLM RecQ helicase.
Giordano Liberi,Giulio Maffioletti,Chiara Lucca,Irene Chiolo,Anastasia Baryshnikova,Cecilia Cotta-Ramusino,Massimo Lopes,Massimo Lopes,Achille Pellicioli,James E. Haber,Marco Foiani +10 more
TL;DR: It is suggested that, in sgs1 cells, the unscheduled accumulation of Rad51-dependent cruciform structures at damaged forks result from defective maturation of recombination-dependent intermediates that originate from the replication-related sister chromatid junctions.