Li-Shiun Chen

TL;DR: The largest genome-wide association study to date of DSM-IV-diagnosed AD found loci associated with AD and characterized the relationship between AD and other psychiatric and behavioral outcomes, underscoring the genetic distinction between pathological and nonpathological drinking behaviors.

TL;DR: Testing whether variants in the nicotinic receptor gene cluster CHRNA5-CHRNA3-CHRNB4 predict age at smoking cessation and relapse after an attempt to quit smoking found this work may support the development of personalized cessation treatments.

TL;DR: The largest GWAS to date of DSM - IV diagnosed AD found loci associated with AD and the relationship between AD and other psychiatric and behavioral outcomes, underscoring the genetic distinction between pathological and non - pathological drinking behaviors.

TL;DR: Nicotine replacement therapy is effective among individuals with fast, but not slow, CYP2A6-defined nicotine metabolism, and the effect of bupropion on relapse likelihood is unlikely to be affected by nicotine metabolism as estimated from CYP1A6 genotype.

TL;DR: In this paper, the observed consistent association of rs16969968 with heavy smoking across multiple populations, combined with its known biological significance, suggests it is most likely a functional variant that alters risk for heavy smoking.