Anja Richter

TL;DR: This study reveals the microanatomy and microphysiology of an Escherichia coli macrocolony biofilm at an unprecedented cellular resolution, with physiologically different zones and strata forming as a function of known global regulatory networks that respond to biofilm-intrinsic gradients of nutrient supply.

TL;DR: In this article, the authors used scanning electron and fluorescence microscopy to locate cellulose filaments, sheets and nanocomposites with curli fibers within the physiologically two-layered macrocolony biofilms of E. coli K-12 strain W3110.

TL;DR: Results show that non-self-reactive virus-neutralizing mAbs elicited during SARS-CoV-2 infection are a promising therapeutic strategy and should be guided by immunization strategies.

TL;DR: In this paper, the authors show that SARS-CoV-2 infection modulates cellular metabolism and limits autophagy, and identify druggable host pathways for virus inhibition.

TL;DR: The results provide the basis for a novel model of local c-di-GMP signaling in which a single strongly expressed master PDE, PdeH, dynamically eradicates global effects of several DGCs by strongly draining the global c- di-G MP pool and thereby restricting these D GCs to serving as local c+GMP sources that activate specific colocalized effector/target systems.