Charles Rosenblum

TL;DR: A heterotrimeric GTP-binding protein (G protein)-coupled receptor (GPC-R) of the pituitary and arcuate ventro-medial and infundibular hypothalamus of swine and humans was cloned and was shown to be the target of the GHSs.

TL;DR: Mc3r and Mc4r serve non-redundant roles in the regulation of energy homeostasis by studying Mc3r-deficient mice and comparing their functions in mice deficient for both genes.

TL;DR: It is shown that the melanocortin 4 receptor, implicated in the control of food intake and energy expenditure, also modulates erectile function and sexual behavior, and evidence is provided that MC4R-mediated proerectile responses may be activated through neuronal circuitry in spinal cord erectile centers and somatosensory afferent nerve terminals of the penis.

TL;DR: It is reported here that CNTF and leptin activate a similar pattern of STAT factors in neuronal cells, and that mRNAs for CNTF receptor subunits, similarly to the mRNA of leptin receptor, are localized in mouse hypothalamic nuclei involved in the regulation of energy balance.

TL;DR: The results suggest that pharmacological intervention with small molecules that disrupt apoE4 domain interaction is a potential therapeutic approach for apOE4-carrying AD subjects.