C
Charles Rosenblum
Researcher at Merck & Co.
Publications - 63
Citations - 4946
Charles Rosenblum is an academic researcher from Merck & Co.. The author has contributed to research in topics: Leptin & Leptin receptor. The author has an hindex of 24, co-authored 63 publications receiving 4771 citations. Previous affiliations of Charles Rosenblum include Pennington Biomedical Research Center.
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Journal ArticleDOI
A Receptor in Pituitary and Hypothalamus That Functions in Growth Hormone Release
Andrew D. Howard,Scott D. Feighner,Doris F. Cully,Joseph P. Arena,Paul A. Liberator,Charles Rosenblum,Michel J. Hamelin,Donna L. Hreniuk,Oksana C. Palyha,Jennifer W. Anderson,Philip S. Paress,Carmen Diaz,Michael Chou,Ken K. Liu,Karen K. McKee,Sheng-Shung Pong,Lee-Yuh Chaung,Alex Elbrecht,Mike Dashkevicz,Robert P. Heavens,Michael Rigby,Dalip J. S. Sirinathsinghji,Dennis C. Dean,David G. Melillo,Arthur A. Patchett,Ravi P. Nargund,Patrick R. Griffin,Julie A. DeMartino,Sunil Gupta,James M. Schaeffer,Roy G. Smith,Lex H.T. Van der Ploeg +31 more
TL;DR: A heterotrimeric GTP-binding protein (G protein)-coupled receptor (GPC-R) of the pituitary and arcuate ventro-medial and infundibular hypothalamus of swine and humans was cloned and was shown to be the target of the GHSs.
Journal ArticleDOI
Inactivation of the mouse melanocortin-3 receptor results in increased fat mass and reduced lean body mass.
Airu S. Chen,Donald J. Marsh,Myrna E. Trumbauer,Easter G. Frazier,Xiao-Ming Guan,Hong Yu,Charles Rosenblum,Aurawan Vongs,Yue Feng,Linhai Cao,Joseph M. Metzger,Alison M. Strack,Ramon E. Camacho,Theodore N. Mellin,Christian N. Nunes,William Min,Jill K. Fisher,Shobhna Gopal-Truter,D. Euan MacIntyre,Howard Y. Chen,Lex H.T. Van der Ploeg +20 more
TL;DR: Mc3r and Mc4r serve non-redundant roles in the regulation of energy homeostasis by studying Mc3r-deficient mice and comparing their functions in mice deficient for both genes.
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A role for the melanocortin 4 receptor in sexual function.
Lex H.T. Van der Ploeg,William J. Martin,Andrew D. Howard,Ravi P. Nargund,Christopher P. Austin,Xiao-Ming Guan,Jennifer E. Drisko,Doreen E. Cashen,Iyassu K. Sebhat,Arthur A. Patchett,David J. Figueroa,Anthony G. DiLella,Brett Connolly,David H. Weinberg,Carina P. Tan,Oksana C. Palyha,Sheng-Shung Pong,Tanya MacNeil,Charles Rosenblum,Aurawan Vongs,Rui Tang,Hong Yu,Andreas W. Sailer,Tung Ming Fong,Cathy R.-R.C. Huang,Michael R. Tota,R. S. L. Chang,Ralph A. Stearns,Constantin Tamvakopoulos,George J. Christ,Deborah L. Drazen,Brian D. Spar,Randy J. Nelson,D. Euan MacIntyre +33 more
TL;DR: It is shown that the melanocortin 4 receptor, implicated in the control of food intake and energy expenditure, also modulates erectile function and sexual behavior, and evidence is provided that MC4R-mediated proerectile responses may be activated through neuronal circuitry in spinal cord erectile centers and somatosensory afferent nerve terminals of the penis.
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Ciliary neurotrophic factor corrects obesity and diabetes associated with leptin deficiency and resistance
Isabelle Gloaguen,Patrizia Costa,Anna Demartis,Domenico Lazzaro,Annalise Di Marco,Rita Graziani,Giacomo Paonessa,Fang Chen,Charles Rosenblum,Lex H.T. Van der Ploeg,Riccardo Cortese,Gennaro Ciliberto,Ralph Laufer +12 more
TL;DR: It is reported here that CNTF and leptin activate a similar pattern of STAT factors in neuronal cells, and that mRNAs for CNTF receptor subunits, similarly to the mRNA of leptin receptor, are localized in mouse hypothalamic nuclei involved in the regulation of energy balance.
Journal ArticleDOI
Apolipoprotein E4 domain interaction mediates detrimental effects on mitochondria and is a potential therapeutic target for Alzheimer disease.
Hung-Kai Chen,Zhong-Sheng Ji,Sara E. Dodson,Rene D. Miranda,Charles Rosenblum,Ian J. Reynolds,Stephen B. Freedman,Karl H. Weisgraber,Yadong Huang,Robert W. Mahley +9 more
TL;DR: The results suggest that pharmacological intervention with small molecules that disrupt apoE4 domain interaction is a potential therapeutic approach for apOE4-carrying AD subjects.